A SUBCUTANEOUSLY ADMINISTERED INVESTIGATIONAL RNAI THERAPEUTIC (ALN-CC5) TARGETING COMPLEMENT C5 FOR TREATMENT OF PNH AND COMPLEMENT-MEDIATED DISEASES: INTERIM PHASE 1 STUDY RESULTS

EHA Library, Anita Hill, 135230

A FUSION PROTEIN OF INTERLEUKIN-4 AND INTERLEUKIN-10 PROTECTS AGAINST BLOOD-INDUCED CARTILAGE DAMAGE IN VITRO AND IN VIVO

EHA Library, Lize van Vulpen, 135225

CHILDREN WITH SICKLE CELL ANEMIA ON CHRONIC TRANSFUSION FOR ABNORMAL TRANSCRANIAL DOPPLER VELOCITIES. PATIENT/SIBLING COMPARISON OF COGNITIVE PERFORMANCES AND ASSOCIATION WITH NEUROIMAGING DATA

EHA Library, Francoise Bernaudin, 135220

GLUCOSE AND LIPID METABOLISM ABNORMALITIES DURING NILOTINIB TREATMENT AND COMPARISON WITH IMATINIB AND DASATINIB THERAPY ? RESULTS FROM ENIGMA 2 STUDY

EHA Library, Zdenek Racil, 135189

BONE MARROW FAILURE IN PAROXYSMAL NOCTURNAL HEMOGLOBULINURIA IS ASSOCIATED WITH EXPANSION OF ANTIGEN-SELECTED T CELLS: HIGH-THROUGHPUT EVIDENCE

EHA Library, Evangelia Stalika, 135229

RESPONSIVENESS OF HEMOPHILIA B-CAUSING NONSENSE MUTATIONS TO RIBOSOME READTHROUGH-INDUCING DRUGS STRICTLY DEPENDS ON THE NUCLEOTIDE AND PROTEIN CONTEXT

EHA Library, Alessio Branchini, 135224

DOPPLER ULTRASOUND RELIABLY IDENTIFIES SICKLE CELL DISEASE ADULT PATIENTS WITH INTRACRANIAL VASCULOPATHY

EHA Library, Pablo Bartolucci, 135219

FLT3-D835Y AND NPM1C ONCOGENES COOPERATE TO INDUCE AN AGGRESSIVE MPN IN MICE.

EHA Library, Alina Rudorf, 135214

IMPACT OF THE MOLECULAR PROFILE ON THE RISK OF ACUTE MYELOID TRANSFORMATION IN PATIENTS WITH POLYCYTHEMIA VERA AND ESSENTIAL THROMBOCYTHEMIA

EHA Library, Alberto Alvarez-Larrán, 135209

A NEW MULTIPLE MYELOMA CLASSIFICATION SYSTEM THAT CORRELATES TO DISEASE STAGE AND PROGNOSIS - INDICATION OF REVERSIBLE PHENOTYPIC PLASTICITY AS A HALLMARK

EHA Library, Hans Erik Johnsen, 135204

INTEGRATIVE GENOMICS IDENTIFIES THE MOLECULAR BASIS OF RESISTANCE TO AZACITIDINE THERAPY IN MYELODYSPLASTIC SYNDROMES

EHA Library, Ashwin Unnikrishnan, 135199

OVERALL SURVIVAL OUTCOMES IN PATIENTS WITH MANTLE-CELL LYMPHOMA (MCL) TREATED WITH IBRUTINIB IN A POOLED ANALYSIS OF 370 PATIENTS FROM 3 INTERNATIONAL OPEN-LABEL STUDIES

EHA Library, Simon Rule, 135194

QUANTITATIVE MRD IS PROGNOSTIC FOR PROGRESSION-FREE & OVERALL SURVIVAL IN ELDERLY PATIENTS RECEIVING CHLORAMBUCIL ALONE OR WITH OBINUTUZUMAB/RITUXIMAB: A PROSPECTIVE ANALYSIS OF THE GCLLSG CLL11 STUDY

EHA Library, Matthias Ritgen, 135184

DYSREGULATED MIR34A/DIACYLGLYCEROL KINASE ? INTERACTION ENHANCES T-CELL ACTIVATION IN ACQUIRED APLASTIC ANEMIA

EHA Library, Yuanxin Sun, 135228

FIRST RESULTS FROM A DOSE-ESCALATING STUDY WITH AAV5 VECTOR CONTAINING WILD TYPE HUMAN FACTOR IX GENE THERAPY IN PATIENTS WITH SEVERE OR MODERATELY-SEVERE HAEMOPHILIA B

EHA Library, Frank Leebeek, 135223

RESULTS OF TRANSCRANIAL DOPPLER ULTRASOUND SCREENING FROM THE POST-STOP STUDY

EHA Library, Julie Kanter, 135218

NPM1 AND FLT3-ITD MUTATIONS SINERGISTICALLY INDUCE GATA1 EPIGENETIC SILENCING IN A AML MOUSE MODEL

EHA Library, Paolo Sportoletti, 135213

LONG-TERM OUTCOMES OF RUXOLITINIB (RUX) THERAPY IN PATIENTS (PTS) WITH MYELOFIBROSIS (MF): 5-YEAR FINAL EFFICACY AND SAFETY ANALYSIS FROM COMFORT-I

EHA Library, Srdan Verstovsek, 135208

A TARGETED SEQUENCING APPROACH IN MULTIPLE MYELOMA REVEALS A COMPLEX LANDSCAPE OF GENOMIC LESIONS THAT HAS IMPLICATIONS FOR PROGNOSIS

EHA Library, Niccolò Bolli, 135203

DYNAMICS OF CLONAL EVOLUTION IN MYELODYSPLASTIC SYNDROMES.

EHA Library, Hideki Makishima, 135198

15-YEAR FOLLOW-UP OF THE NORDIC MCL2-TRIAL: DESPITE LONG-TERM RESPONSES LATE RELAPSES STILL OCCUR.

EHA Library, Christian Winther Eskelund, 135193

EFFICACY AND SAFETY OF IMATINIB GENERICS; A REPORT FROM POLISH (PALG) IMATINIB GENERICS REGISTRY

EHA Library, Tomasz Sacha, 135188

PRELIMINARY SAFETY DATA FROM THE PHASE 3B GREEN STUDY OF OBINUTUZUMAB (G) ALONE OR COMBINED WITH CHEMOTHERAPY FOR PREVIOUSLY UNTREATED OR RELAPSED/REFRACTORY CHRONIC LYMPHOCYTIC LEUKEMIA (CLL)

EHA Library, Véronique Leblond, 135183

Patents and diagnostic testing: another marriage on the rocks or a(n) (un)wanted relationship?

EHA Library, Sven Bostyn, 137078

Clones and subclones during ALL development

EHA Library, Jan Trka, 137083

Patenting in diagnostics: Damned if you do, damned if you don't

EHA Library, Eric Claassen, 137077

Oncogenetic heterogeneity of ALL cells

EHA Library, Stephen P. Hunger, 137082

Q&A and Panel Discussion

EHA Library, Faculty / Presenters, 141696

The meaning of circulating plasma cells in myeloma patients

EHA Library, Bruno Paiva, 137072

Symptoms and health-related quality of life issues considered important by patients with hematological malignancies: Patient perspective

EHA Library, Roger Else, 137067

Multiple myeloma: Spatial genomic heterogeneity between focal lesions and random bone marrow

EHA Library, Niels Weinhold, 137071

Challenges of assessing symptom burden in patients with hematological malignancies: Academic perspective

EHA Library, Tatyana Ionova, 137066

Hemostatic management of bleeding in obstetrics and gynecology

EHA Library, Claire Philipp, 136658

Genetic basis of rare inherited platelet disorders in the era of next-generation sequencing

EHA Library, Kathleen Freson, 136657

B-cell maturation pathways and migration

EHA Library, Alberto Orfao, 137070

Challenges of assessing symptoms for monitoring response to treatment in patients with ematological malignancies: Learning from best practice

EHA Library, Jonathan Kell, 137065

Blood outgrowth endothelial cells in understanding von Willebrand disease

EHA Library, Anna Randi, 136656

International Harmonization Group For Surveillance Of Late Effects Of Childhood Cancer

EHA Library, Leontien Kremer, 136655

The spectrum of late effects after cancer, lessons from pediatric oncology, and the value of international collaboration

EHA Library, Roderick Skinner, 136654

Deciphering genetic variation of early and late effects from childhood cancer therapies

EHA Library, Bruce Carleton, 136653

Antiplatelet therapy in acute and chronic ischemic heart disease

EHA Library, Freek Verheugt, 136652

Platelet reactivity testing: Is there a clinical relevance?

EHA Library, Jolanta Siller-Matula, 136651

Platelets and immunity

EHA Library, Harald Langer, 136650

Treatment of HLH in adults

EHA Library, Nancy Berliner, 136649

Malignancy associated HLH

EHA Library, Milen Minkov, 136648

HLH: Variations in etiology, pathophysiology and manifestations

EHA Library, Michael Jordan, 136647

The role of the blood film in diagnosing and managing red cell disorders

EHA Library, Barbara Bain, 136646

Clinical trials and potential targets of therapy in sickle cell disease

EHA Library, Bart Biemond, 136645

Anemia of chronic disease - New insights into its pathophysiology and therapy

EHA Library, Guenter Weiss, 136644

Mesenchymal Stem Cells As Treatment Of Chronic GvHD

EHA Library, Katarina Le Blanc, 136676

GVHD prophylaxis with PTCy

EHA Library, leo leonio, 136675

Recent advances in understanding the pathophysiology of GVHD

EHA Library, Ron Chakraverty, 136674

ADULTS AND CHILDREN (1-45 YEARS) WITH PH-NEGATIVE ALL HAVE ALMOST IDENTICAL OUTCOME IN RISK-STRATIFIED ANALYSIS OF NOPHO ALL2008

EHA Library, Nina Toft, 135343

INITIAL RESULTS FROM UKALL60+, A UK/HOVON COLLABORATIVE PHASE 2 STUDY IN ELDERLY PATIENTS WITH ACUTE LYMPHOBLASTIC LEUKAEMIA.

EHA Library, Nick MORLEY, 133159

RISK OF CEREBRAL VEIN THROMBOSIS (CVT) IN ADULT ALL PATIENTS IN FINLAND 1999-2012: SUGGESTION FOR A LEUKEMIA-RELATED PREDICTIVE SCORING MODEL

EHA Library, Saara Roininen, 133158

EFFICACY OF FRONT-LINE TREATMENT COMBINATIONS WITH PONATINIB VERSUS 1ST- AND 2ND-GENERATION TYROSINE KINASE INHIBITORS FOR PH+ ACUTE LYMPHOBLASTIC LEUKEMIA: A META-ANALYSIS AND META-REGRESSION

EHA Library, Elias Jabbour, 133157

THE COMBINATION OF BORTEZOMIB AND CHEMOTHERAPY IS AN EFFECTIVE TREATMENT TO RE-INDUCE REMISSION IN RELAPSED/REFRACTORY B-CELL PRECURSOR OR T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA

EHA Library, Alice Bertaina, 133156

EFFICACY AND SAFETY OF INOTUZUMAB OZOGAMICIN IN OLDER PATIENTS WITH RELAPSED/REFRACTORY ACUTE LYMPHOBLASTIC LEUKEMIA ENROLLED IN THE GLOBAL PHASE 3 RANDOMIZED CONTROLLED INO-VATE TRIAL

EHA Library, Elias Jabbour, 133155

TOLERANCE, COMPLIANCE AND EFFICACY OF L-ASPARAGINASE DURING INDUCTION PHASE IN ADULT PHILADELPHIA-NEGATIVE ACUTE LYMPHOBLASTIC LEUKEMIA: EXPERIENCE OF THE GRAALL-2005.

EHA Library, Marie Balsat, 133154

HIGH INCIDENCE OF PHILADELPHIA CHROMOSOME-LIKE ACUTE LYMPHOBLASTIC LEUKEMIA (PH-LIKE ALL) IN OLDER ADULTS WITH B-ALL

EHA Library, Alexander Perl, 133153

BABOON ENVELOPE PSEUDOTYPED LENTIVIRAL VECTORS: A HIGHLY EFFICIENT NEW TOOL TO GENETICALLY MANIPULATE T-CELL ACUTE LYMPHOBLASTIC LEUKAEMIA INITIATING CELLS

EHA Library, Melania Tesio, 133152

MUTATIONAL STATUS OF NRAS, KRAS AND PTPN11 GENES IS ASSOCIATED WITH GENETIC/CYTOGENETIC FEATURES IN CHILDREN WITH B-PRECURSOR ACUTE LYMPHOBLASTIC LEUKEMIA

EHA Library, Der-Cherng Liang, 133151

LOSS OF PIGH EXPRESSION FREQUENTLY RESULTS IN A GPI-NEGATIVE SUBCLONE LACKING CD52 MEMBRANE EXPRESSION, CONFERRING ALEMTUZUMAB RESISTANCE TO B CELL ACUTE LYMPHOBLASTIC LEUKEMIA

EHA Library, Inge Jedema, 133150

INTRINSIC AND SYNERGISTIC ACTIVITY OF ABT-199 AND OVERCOMING ABT-199 RESISTANCE BY THE CDK-INHIBITOR DINACICLIB IN B-CELL PRECURSOR ACUTE LYMPHOBLASTIC LEUKEMIA

EHA Library, Felix Seyfried, 133149

DEVELOPMENT OF A NOVEL FIRST-IN-CLASS ORAL INHIBITOR OF THE NOTCH PATHWAY.

EHA Library, Rajwinder Lehal, 133148

DETERMINING THE MUTATIONAL LANDSCAPE OF T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA REVEALS NR3C1 DELETIONS AND ACTIVATING MUTATIONS IN IL7R SIGNALING AS CAUSE OF STEROID RESISTANCE

EHA Library, Jules Meijerink, 133147

FUNCTIONAL RESTORATION OF MUTANT P53 AND CELL DEATH SENSITIZATION IN ACUTE LYMPHOBLASTIC LEUKEMIA

EHA Library, Salih demir, 133146

CHARACTERIZATION OF AN EX VIVO T-CELL CULTURE MODEL FOR THE STUDY OF T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA

EHA Library, Simon Bornschein, 133145

CLINICAL AND BIOLOGICAL LANDSCAPE OF DRIVER MUTATIONS IN PEDIATRIC ACUTE LYMPHOBLASTIC LEUKEMIA

EHA Library, Hiroo Ueno, 133144

THE NUP214-ABL1 FUSION COOPERATES WITH TLX1 IN THE DEVELOPMENT OF T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA

EHA Library, Marlies Vanden Bempt, 133143

RELAPSE OF ACUTE LYMPHOBLASTIC LEUKAEMIA IN OLDER/ELDERLY PATIENTS - A SWEDISH POPULATION-BASED STUDY

EHA Library, Emma Bergfelt Lennmyr, 133160

MICRORNA-155 AND MICRORNA-708 ARE OPPOSING MODULATORS OF HOXA9 ACTIVITY IN ACUTE MYELOID LEUKEMIA

EHA Library, Edith Schneider, 133161

A SOMATIC MUTATION OF GFI1B IDENTIFIED IN LEUKEMIA ALTERS CELL FATE VIA A SPI1 (PU.1) CENTERED GENETIC REGULATORY NETWORK

EHA Library, Eduardo Anguita, 133165

VENTX INDUCES EXPANSION OF PRIMITIVE ERYTHROID CELLS AND CONTRIBUTES TO THE DEVELOPMENT OF ACUTE MYELOID LEUKEMIA IN MICE

EHA Library, Eva Gentner, 133162

ABNORMAL INTRAGENIC TRANSCRIPTIONAL ACTIVATION IN MLL-AF9 AND KAT6A-CREBBP ACUTE MYELOID LEUKEMIA (AML)

EHA Library, Anna Marneth, 133163

HHEX TRANSFORMS PROMYELOCYTES AND COOPERATES WITH FACTOR INDEPENDENCE TO CAUSE PROMYELOCYTIC LEUKEMIA IN MICE

EHA Library, Jacob T Jackson, 133164

CXCL12 ANTAGONISM BY THE L-RNA APTAMER OLAPTESED PEGOL IS EFFECTIVE AS A MOBILIZING AND THERAPEUTIC AGENT IN A MURINE CHRONIC LYMPHOCYTIC LEUKEMIA MODEL

EHA Library, Tanja Hartmann, 133184

IDENTIFICATION OF NOVEL B CELL RECEPTOR ANTIGENS IN CHRONIC LYMPHOCYTIC LEUKEMIA

EHA Library, Elisa ten Hacken, 133183

GENOMIC CHARACTERIZATION OF HIGH-COUNT MBL INDIVIDUALS INDICATES THAT EARLYDETECTION OF DRIVER MUTATIONS AND SUBCLONAL EXPANSION ARE PREDICTORS OF ADVERSECLINICAL OUTCOME

EHA Library, Santiago Barrio, 133182

A PHASE I TRIAL OF A PHARMACODYNAMICALLY-CONCEIVED DECITABINE/THIOGUANINE COMBINATION IN PATIENTS WITH ADVANCED MYELOID MALIGNANCIES

EHA Library, Mark Frattini, 133181

RESULTS OF A PHASE 1B STUDY OF VENETOCLAX PLUS DECITABINE OR AZACITIDINE IN UNTREATED ACUTE MYELOID LEUKEMIA PATIENTS ≥65 YEARS INELIGIBLE FOR STANDARD INDUCTION THERAPY

EHA Library, Daniel A Pollyea, 133180

RESULTS OF A PHASE I STUDY OF GMI-1271, A NOVEL E-SELECTIN ANTAGONIST IN COMBINATION WITH INDUCTION CHEMOTHERAPY IN RELAPSED/REFRACTORY AML: A NOVEL, WELL-TOLERATED REGIMEN WITH A HIGH REMISSION RATE

EHA Library, Helen Thackray, 133179

CLINICAL RESPONSE IN RELAPSED/REFRACTORY AML PATIENTS CORRELATES WITH LEUKEMIC BLAST MOBILIZATION AND DIFFERENTIATION INDUCED BY BL-8040, A POTENT CXCR4 ANTAGONIST; RESULTS OF A PHASE IIA STUDY

EHA Library, Yaron Pereg, 133178

PHASE IB/II STUDY OF NIVOLUMAB IN COMBINATION WITH 5-AZACYTIDINE (AZA) IN PATIENTS (PTS) WITH RELAPSED ACUTE MYELOID LEUKEMIA (AML)

EHA Library, Naval Daver, 133177

DIFFERENTIATION RESPONSE TO GILTERITINIB (ASP2215) IN RELAPSED/REFRACTORY FLT3 MUTATED ACUTE MYELOID LEUKEMIA PATIENTS IS ASSOCIATED WITH CO-MUTATIONS IN NPM1 AND DNMT3A

EHA Library, Jonathan Canaani, 133176

PHASE II STUDY OF CLADRIBINE AND LOW-DOSE ARAC ALTERNATING WITH DECITABINE IN OLDER PATIENTS WITH AML.

EHA Library, Tapan Kadia, 133175

SAFETY STUDY OF CRENOLANIB, A TYPE I FLT3 INHIBITOR, WITH CYTARABINE/DAUNORUBICIN OR CYTARABINE/IDARUBICIN INDUCTION AND HIGH-DOSE CYTARABINE CONSOLIDATION IN NEWLY DIAGNOSED FLT3+ AML

EHA Library, Eunice Wang, 133174

ORAL THROMBOPOIETIN RECEPTOR AGONIST ELTROMBOPAG TREATMENT DURING INDUCTION CHEMOTHERAPY FOR ACUTE MYELOGENOUS LEUKEMIA (AML): RESULTS OF A RANDOMIZED, DOUBLE-BLIND, PHASE 2 STUDY

EHA Library, Noëlle Frey, 133173

AN EVALUATION OF THE TYROSINE KINASE INHIBITOR PACRITINIB IN PATIENTS WITH RELAPSED FLT3-MUTATED ACUTE MYELOID LEUKAEMIA (THE UK NCRI AML17 STUDY)

EHA Library, Steven , 133172

CHROMOTHRIPSIS: A NEW MECHANISM OF CANCER INITIATION AND PROGRESSION IN ADULT ACUTE MYELOID LEUKEMIA

EHA Library, Maria Chiara Fontana, 133171

TRIB2 REGULATES THE CELL CYCLE UNDER STRESS CONDITIONS IN A MURINE CELL MODEL OF LEUKEMIA.

EHA Library, Mara Salomè, 133170

TRIB2 TRANSFORMED GMP AS THE MYELOID LEUKEMIA INITIATING CELL

EHA Library, Krishna Yalla, 133169

CONDITIONAL DELETION OF THE HOXA CLUSTER IN MLL-AF9 IS INCOMPATIBLE WITH LEUKEMIA MAINTENANCE

EHA Library, Laura Kettyle, 133168

TRANSFORMING ACTIVITY OF THE NUP98-MLL FUSION IN A CONDITIONAL TRANSGENIC MOUSE MODEL

EHA Library, Angeliki Thanasopoulou, 133167

COMPARATIVE FUNCTIONAL ANALYSIS OF THE COMMON INTERACTORS OF 7 MLL FUSION PROTEINS

EHA Library, Anna Skucha, 133166

A PLATFORM FOR DETECTION OF FUSION GENES IN ALL FROM TARGET CAPTURE NEXT-GENERATION SEQUENCING OF DNA AND RNA.

EHA Library, Andrea Grioni, 133142

IDENTIFICATION OF CANDIDATE ONCOGENES AND CHROMOSOMAL BREAKPOINT SEQUENCING BY TARGETED LOCUS AMPLIFICATION IN T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA

EHA Library, Pieter Van Vlierberghe, 133141

HEDGEHOG PATHWAY ACTIVATION IN T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA PREDICTS RESPONSE TO SMO AND GLI1 INHIBITORS

EHA Library, Jolien De Bie, 133140

MEF2C DYSREGULATION IS ASSOCIATED WITH CDKN1B DELETIONS AND PREDICTS POOR GLUCOCORTICOID RESPONSE IN PEDIATRIC T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA

EHA Library, Sara Colomer-Lahiguera, 133139

COMPARATIVE ANALYSIS OF GENE REGULATORY NETWORKS IN LYMPHOID LEUKEMIAS USING THE INTERACTIVE HEMAP RESOURCE

EHA Library, Juha Mehtonen, 133138