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All TopicsAll Topics▸Section 1: Clinical hematology: Non-malignant hematology▸1A Red cell and iron disorders-1Aa Anemias due to deficiency (iron, B12, folate)-1Ab Anemia of chronic disease-1Ac Anemia due to toxic exposure-1Ad Pure red cell aplasia-1Ae Thalassemia including HbE disorders-1Af Sickle cell disease-1Ah Red blood cell membrane and enzyme disorders (e.g. Spherocytosis and G6PD deficiency)-1Ag Other hemoglobinopathies-1Ai Acquired immune hemolytic anemias-1Aj Acquired non-immune hemolytic anemias-1Ak Other congenital anemias (CDA, sideroblastic anemia)-1Al Erythrocytosis (other than PV)-1Am Primary hemochromatosis-1An Secondary hemochromatosis-1Ao Porphyria and other rare metabolic disorders (e.g. Gaucher, methemoglobinemia)▸1B Bone marrow failure-1Ba Acquired aplastic anemia-1Bb Paroxysmal nocturnal hemoglobinuri-1Bc Fanconi’s anemia-1Bd Other inherited bone marrow failure syndromes (e.g. Blackfan-Diamond, Dyskeratosis congenital, Telomere diseases)-1Be Idiopathic cytopenia of undetermined significance (ICUS)▸1C Non-malignant white blood cell disorders-1Ca Granulocyte dysfunction disorders-1Cb Congenital granulocytopenia-1Cc Acquired granulocytopenia-1Cd Lymphopenia and Immune deficiency syndromes-1Ce Hemophagocytic lymphohistiocytosis-1Cf Secondary leukocytosis-1Cg Eosinophilia▸1D Platelet disorders and angiopathies-1Dc Heparin-induced thrombocytopenia-1Dd Thrombocytopenia in pregnancy-1Da Immune thrombocytopenia-1Db Thrombotic microangiopathies (e.g. TTP)-1De Disorders with telangiectasias (e.g. Rendu-Osler-Weber disease) (For other platelet disorders see section Coagulation)▸1E Consultative hematology-1Ef Hyposplenism and hypersplenism-1Ec Hematological variations and abnormalities in pregnancy-1Eb Hematological manifestations of congenital metabolism disorders-1Ea Hematological manifestations of non-hematological disorders-1Ed Neonatal hematological variations and abnormalities-1Ee Hematological manifestations in HIV and other infectious diseases▸Section 2: Clinical hematology: Myeloid malignancies▸2A Myeloproliferative and myelodysplastic neoplasm-2Aa Chronic myeloid leukemia, BCR-ABL1-positive-2Ab Polycythemia vera-2Ac Myelofibrosis-2Ad Essential thrombocythemia-2Ag Myelodysplastic syndromes-2Ae Mastocytosis-2Ah Other Myeloproliferative and Myelodysplastic disorders in adults-2Af Myelodysplastic/myeloproliferative neoplasms▸2C Pediatric myeloid disorders-2Cb JMML-2Ca Myeloid proliferations related to Down syndrome-2Cc Myelodysplastic syndromes-2Cd AML▸2B Acute myeloid leukemia (AML) and leukemias of ambiguous lineage-2Ba AML with recurrent genetic abnormalities-2Bb AML with MDS related changes-2Bc Therapy related AML and MDS-2Bd Other AML (including genetic predisposition syndromes)-2Be Acute leukemia of ambiguous lineage▸Section 3: Clinical hematology Lymphoid malignancies and plasma cell disorders▸3A B-cell neoplasms and B-cell disorders-3Aa B lymphoblastic leukemia/lymphoma-3Ab Diffuse large B-cell lymphoma-3Ac Burkitt's lymphoma-3Ad Rare aggressive B-cell lymphomas (e.g. double-hit, intravascular, plasmablastic, ALK+ and ALK- large B-cell lymphoma-3Ae Mantle cell lymphoma-3Af Follicular lymphoma-3Ag Other indolent B-cell lymphomas (e.g. lymphoplasmacytic lymphoma, hairy cell leukemia)-3Ah Marginal zone lymphomas-3Aj Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL)-3Ai Monoclonal B-cell lymphocytosis (MBL)▸3B T-cell lymphomas and NK-cell neoplasms-3Ba T lymphoblastic leukemia/lymphoma-3Bb Common T-cell lymphomas-3Bc Rare T- and NK-cell lymphomas▸3C Hodgkin lymphoma-3Cb Nodular lymphocyte predominant HL-3Ca Classical HL▸3D Other special entities-3De Castlemann disease-3Da Lymphomas in immunodeficient patients (including PTLD, HIV-associated lymphoma)-3Db Cutaneous lymphomas-3Dc Primary CNS lymphoma-3Dd Histiocytic and dendritic cell neoplasms▸3E Plasma cell neoplasms-3Ea Monoclonal gammopathy of undetermined significance (MGUS)-3Eb Solitary plasmacytoma-3Ec Plasma cell myeloma (Multiple myeloma)-3Ed Monoclonal immunoglobulin deposition diseases (e.g. amyloidosis)▸3F Pediatric lymphoid malignancies-3Fa Acute lymphoblastic leukemia (B or T)-3Fb Pediatric lymphoma▸Section 4: Treatment of hematological disorders▸4B Stem cell transplantation and other cellular therapies-4Ba Indication for autologous stem cell transplantation-4Bd Criteria for selection of intensity for the preparative regimens-4Be Identification and selection of stem cell donor-4Bf Acute and chronic graft versus host disease-4Bg Pulmonary complications, veno-occlusive disease of the liver, hemorrhagic cystitis and other complications-4Bc Mobilization, collection and manipulation of hematopoeitic stem cells-4Bj Indication for specific and gene-modified cell therapy-4Bb Indication for allogeneic stem cell transplantation-4Bh Post-transplant monitoring-4Bi Late complication (including long term follow-up)▸4A Principals of treatment-4Aa Drug therapy including targeted drugs: mechanisms of action, pharmacology and drug resistance-4Ab Short and long term complications of chemotherapy and radiotherapy-4Ac Hematological malignancies in pregnancy▸4C Infectious complications-4Ca Neutropenic fever (including growth factors)-4Cb Bacterial infection-4Cc Fungal disease-4Cd Cytomegalovirus (CMV) /EBV , herpes, hepatitis and other viral infections▸4D Supportive and emergency care-4Da Hyperleukocytosis, hyperviscosity, and tumor lysis syndrome-4Db Rare complications (Spinal cord compression and other neurological and psychiatric disturbances, superior vena cava syndrome)-4Dc Nausea and pain management-4Dd Nutrition▸4E Pharmacology and pharmacovigilance-4Ec Drug interactions-4Ed Critically appraisal of biosimilars-4Ea Pharmacovigilance-4Eb Adverse event management▸Section 5: Laboratory diagnosis▸5A Good laboratory practice-5Ae Integrating diagnosis from laboratory investigations and relating them to the clinical picture-5Aa Principles of laboratory management and organization-5Ab Laboratory quality management and accreditation/certification (including internal and external quality control)-5Ac Hazards and safety-5Ad Reference ranges of laboratory values, with relevance to gender, age and ethnicity▸5B Blood count and morphology-5Bf Pseudo thrombocytopenia-5Ba Automated complete blood count with white blood cell differential-5Bb Performing aspiration and biopsy of bone marrow, lumbar puncture and lymph node fine needle aspiration and preparation of slides, touch preparations and trephine rolls-5Bc Preparation, fixation, staining, reading and reporting of peripheral blood smears and bone marrow aspirates and trephine rolls-5Bd Cytochemical, special stains and immunostaining of blood and bone marrow smears in hematological conditions-5Be Review and interpretation of trephine, lymph node and other relevant tissue biopsies together with a pathologist▸5C Other laboratory techniques-5Ce Progenitor quantification in semi-solid culture conditions-5Ca Hemoglobin analyses (e.g. hemoglobin electrophoresis)-5Cb Other red blood cell laboratory techniques (e.g. sickling process, oxygen affinity, red blood cell enzyme assays - pyruvate kinase, glucose-6-phosphate dehydrogenase)-5Cc Laboratory work-up on iron metabolism and vitamin deficiencies-5Cd Detection of immunoglobulin abnormalities▸5D Immunophenotyping by flow cytometry-5Da Clinical applications of flow cytometry for diagnosis, classification, prognosis, evaluation of minimal residual disease and stem cell quantification-5Db Pre-analytical and analytical phase of flow cytometry of blood, bone marrow, and body fluids (e.g. specimen processing, surface vs. intracytoplasmic staining, acquiring data, gating strategies)-5Dc Essential cellular markers, disease-oriented antibody panels applied in hematological conditions-5Dd Data analysis and interpretation (e.g. determination of the lineage of cells of interest, clonality, stem cell quantification, telomere length and specific subtypes of hematological condition)▸5E Genetics and molecular biology-5Ee Other techniques for detection and quantification of recurrent mutations-5Ef Other techniques for gene discovery and expression-5Eb Conventional cytogenetics, chromosome breakage and fluorescence in situ hybridization-5Ec Polymerase chain reactions for the detection of gene mutations, fusion genes, clonality assessment, and gene expression-5Ed Other techniques for detection of copy number variations and gene polymorphisms-5Ea Clinical applications of these techniques for diagnosis, classification, prognosis, minimal residual disease of hematological disorders▸5F Coagulation-5Fa Techniques for assessing coagulation and platelets-5Fb Assays for inhibitors-5Fc Assays for monitoring anticoagulants▸5G Immunohematology-5Ga Red cell typing and allocation-5Gb Minor RBC, platelet and neutrophil antigens-5Gc Laboratory diagnosis of alloimmune and autoimmune cytopenia▸Section 6: Thrombosis and hemostasis▸6A Acquired bleeding disorders-6Aa Massive bleeding in obstetrics, trauma and surgery-6Ab Disseminated intravascular coagulation (DIC)-6Ac Bleeding associated with renal and liver disease-6Ad Bleeding related to anticoagulants and antithrombotic therapy-6Ae Acquired bleeding disorders in adults (inhibitors to F VIII and vWF)-6Af Acquired bleeding disorders in children-6Ag Adverse effects of treatment used in acute bleeding (blood products, pro-hemostatic drugs)▸6B Congenital bleeding disorders-6Ba Hemophilia A & B-6Bb Von Willebrand disease-6Bc Other clotting factor disorders-6Bd Considerations in carriers of hemophilia in relation to pregnancy and management of neonates with hemophilia-6Bf Safety of treatment with blood products and factor concentrates-6Be Congenital platelet disorders▸6C Thrombotic disorders-6Ca Diagnosis and treatment of venous thromboembolism-6Cb Anticoagulant and thrombolytic therapy in other medical conditions-6Cc Thrombophilia (congenital and acquired)-6Cd Treatment and prophylaxis of venous thromboembolism in pregnancy-6Ce Specific therapy in thrombotic disorders (e.g. caval filters)-6Cf Thrombosis in children (including purpura fulminans)▸Section 7: Transfusion medicine▸7B Clinical use of blood components-7Bb Use of blood products and alternatives in medical patients (e.g. liver, renal, cardiac disease, hematological)-7Be Blood alternatives. Management of patients who refuse blood transfusion-7Ba Indication, choice and application of blood components-7Bc Use of blood products and alternatives in surgical and obstetric patients (e.g. trauma, cardiac surgery)-7Bd Use of blood products and alternatives in fetal, neonatal and pediatric patients-7Bf Transfusion reactions and complications (including hemovigilance)▸7C Specific techniques-7Ca Indications and complications of apheresis-7Cb Indications and complications of therapeutic phlebotomy▸7A Blood donation-7Aa Selection of blood donors-7Ab Epidemiology and screening of blood borne infections-7Ac Blood collection procedures▸Section 8: General skills▸8A Basic biological concepts-8Aa Hematopoiesis and stem cell biology-8Ab Chromosome and gene structure-8Ac The role of deoxyribonucleic acid (DNA), ribonucleic acid (RNA) and proteins in normal cellular processes-8Ad Basic concepts of transcription and translation, epigenetic regulation, RNA splicing, signal transduction, cell cycle regulation and apoptosis and methods of investigation-8Ae Mechanisms in hemostasis▸8B Evidence based medicine-8Ba Fundamental principles of evidence based medicine-8Bb Critical appraisal of scientific literature including statistical methods-8Bc Strategic and economic implications of combining drugs and clinical biomarkers▸8C Good clinical practice and clinical trials-8Cb Clinical trial-related international and local guidelines and legislation (GCP)-8Cc Obtaining informed consent in clinical trials and in routine daily medical practice-8Ca Multidisciplinary discussion-making-8Cd Methods for assessing patient reported outcomes including quality of life-8Ce The impact of age on patient management (geriatric/co-morbidity assessment) rephrased▸8D Ethics and law-8Dg Definition and disclosure of conflict of interest as well as current conflict-of-interest policies, (e.g., standards of conduct in collaboration between physicians and industry)-8Da Basic principles of medical ethics (including HELSINKI DECLARATION)-8Db Functions of the Ethics Committee-8Dc National regulations on how to manage a patient with reduced autonomy-8Dd Regulations concerning the use of human cells and tissues (bio-banking)-8De Basic principles of health economics and cost-effectiveness-8Df European and national directives on patient rights▸8E Communication skills and psychosocial issues-8Ee Collecting a history and physical examination directed at hematological diseases, e.g. bleeding disorders, inherited malignancies, etc.-8Ea Communication with patients-8Eb Communication with patients'' relatives and cohabitants-8Ec Communication within a multi-disciplinary team-8Ed Psychosocial assessment▸8F Palliative care and End-of-life-8Fa Palliative care decisions-8Fb Management and decision-making related to end-of-life situations-Section 9: European Hematology Curriculum
Protected by US Patents
Abstract
Abstract: PB2589
Title: A 10 YEAR OVERALL SURVIVAL ANALYSIS OF CHRONIC MYELOID LEUKEMIA PATIENTS TREATED WITH TYROSINE KINASE INHIBITORS IN A MAJOR HAEMATOLOGY CENTRE IN MALAYSIA : A REAL WORLD ANALYSIS
Abstract Type: Publication Only
Keywords: Survival | Tyrosine kinase inhibitor | Chronic myeloid leukemia
Title: A 10 YEAR OVERALL SURVIVAL ANALYSIS OF CHRONIC MYELOID LEUKEMIA PATIENTS TREATED WITH TYROSINE KINASE INHIBITORS IN A MAJOR HAEMATOLOGY CENTRE IN MALAYSIA : A REAL WORLD ANALYSIS
Abstract Type: Publication Only
Keywords: Survival | Tyrosine kinase inhibitor | Chronic myeloid leukemia
Abstract: PB2589
Title: A 10 YEAR OVERALL SURVIVAL ANALYSIS OF CHRONIC MYELOID LEUKEMIA PATIENTS TREATED WITH TYROSINE KINASE INHIBITORS IN A MAJOR HAEMATOLOGY CENTRE IN MALAYSIA : A REAL WORLD ANALYSIS
Abstract Type: Publication Only
Keywords: Survival | Tyrosine kinase inhibitor | Chronic myeloid leukemia
Title: A 10 YEAR OVERALL SURVIVAL ANALYSIS OF CHRONIC MYELOID LEUKEMIA PATIENTS TREATED WITH TYROSINE KINASE INHIBITORS IN A MAJOR HAEMATOLOGY CENTRE IN MALAYSIA : A REAL WORLD ANALYSIS
Abstract Type: Publication Only
Keywords: Survival | Tyrosine kinase inhibitor | Chronic myeloid leukemia
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