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A LARGE FRENCH REAL WORLD MULTICENTRIC PROSPECTIVE COHORT OF PATIENTS WITH LYMPHOMA (REALYSA STUDY): DESCRIPTION OF THE DIFFUSE LARGE B CELL LYMPHOMA PATIENTS IN REAL WORLD IN FRANCE
Author(s): ,
Herve Ghesquieres
Affiliations:
Hopital Lyon Sud,Pierre Benite,France;Hopital Lyon Sud,Pierre Benite,Frankreich;Hopital Lyon Sud,Pierre Benite,Francia;Hopital Lyon Sud,Pierre Benite,France;Hopital Lyon Sud,Pierre Benite,Francia;Hopital Lyon Sud,Pierre Benite,Frankrijk;Hopital Lyon Sud,Pierre Benite,França;Hopital Lyon Sud,Pierre Benite,Франция ;Hopital Lyon Sud,Pierre Benite,Frankrike
,
Fanny Cherblanc
Affiliations:
LYSARC,Pierre-Benite,France;LYSARC,Pierre-Benite,Frankreich;LYSARC,Pierre-Benite,Francia;LYSARC,Pierre-Benite,France;LYSARC,Pierre-Benite,Francia;LYSARC,Pierre-Benite,Frankrijk;LYSARC,Pierre-Benite,França;LYSARC,Pierre-Benite,Франция ;LYSARC,Pierre-Benite,Frankrike
,
Aurélien Belot
Affiliations:
LYSARC,Pierre-Benite,France;LYSARC,Pierre-Benite,Frankreich;LYSARC,Pierre-Benite,Francia;LYSARC,Pierre-Benite,France;LYSARC,Pierre-Benite,Francia;LYSARC,Pierre-Benite,Frankrijk;LYSARC,Pierre-Benite,França;LYSARC,Pierre-Benite,Франция ;LYSARC,Pierre-Benite,Frankrike
,
Vincent Camus
Affiliations:
Centre Henri Becquerel,Rouen,France;Centre Henri Becquerel,Rouen,Frankreich;Centre Henri Becquerel,Rouen,Francia;Centre Henri Becquerel,Rouen,France;Centre Henri Becquerel,Rouen,Francia;Centre Henri Becquerel,Rouen,Frankrijk;Centre Henri Becquerel,Rouen,França;Centre Henri Becquerel,Rouen,Франция ;Centre Henri Becquerel,Rouen,Frankrike
,
Katia Thokagevistk
Affiliations:
Roche,Boulogne-Billancourt,France;Roche,Boulogne-Billancourt,Frankreich;Roche,Boulogne-Billancourt,Francia;Roche,Boulogne-Billancourt,France;Roche,Boulogne-Billancourt,Francia;Roche,Boulogne-Billancourt,Frankrijk;Roche,Boulogne-Billancourt,França;Roche,Boulogne-Billancourt,Франция ;Roche,Boulogne-Billancourt,Frankrike
,
Kamal-Krimo Bouabdallah
Affiliations:
CHU Haut Lévêque,Pessac,France;CHU Haut Lévêque,Pessac,Frankreich;CHU Haut Lévêque,Pessac,Francia;CHU Haut Lévêque,Pessac,France;CHU Haut Lévêque,Pessac,Francia;CHU Haut Lévêque,Pessac,Frankrijk;CHU Haut Lévêque,Pessac,França;CHU Haut Lévêque,Pessac,Франция ;CHU Haut Lévêque,Pessac,Frankrike
,
Cyril Esnault
Affiliations:
Roche,Boulogne-Billancourt,France;Roche,Boulogne-Billancourt,Frankreich;Roche,Boulogne-Billancourt,Francia;Roche,Boulogne-Billancourt,France;Roche,Boulogne-Billancourt,Francia;Roche,Boulogne-Billancourt,Frankrijk;Roche,Boulogne-Billancourt,França;Roche,Boulogne-Billancourt,Франция ;Roche,Boulogne-Billancourt,Frankrike
,
Luc-Matthieu Fornecker
Affiliations:
ICANS,Strasbourg,France;ICANS,Strasbourg,Frankreich;ICANS,Strasbourg,Francia;ICANS,Strasbourg,France;ICANS,Strasbourg,Francia;ICANS,Strasbourg,Frankrijk;ICANS,Strasbourg,França;ICANS,Strasbourg,Франция ;ICANS,Strasbourg,Frankrike
,
Sophie Micon
Affiliations:
Roche,Boulogne-Billancourt,France;Roche,Boulogne-Billancourt,Frankreich;Roche,Boulogne-Billancourt,Francia;Roche,Boulogne-Billancourt,France;Roche,Boulogne-Billancourt,Francia;Roche,Boulogne-Billancourt,Frankrijk;Roche,Boulogne-Billancourt,França;Roche,Boulogne-Billancourt,Франция ;Roche,Boulogne-Billancourt,Frankrike
,
Fontanet Bijou
Affiliations:
Institut Bergonié,Bordeaux,France;Institut Bergonié,Bordeaux,Frankreich;Institut Bergonié,Bordeaux,Francia;Institut Bergonié,Bordeaux,France;Institut Bergonié,Bordeaux,Francia;Institut Bergonié,Bordeaux,Frankrijk;Institut Bergonié,Bordeaux,França;Institut Bergonié,Bordeaux,Франция ;Institut Bergonié,Bordeaux,Frankrike
,
Corinne Haioun
Affiliations:
Hôpital Henri Mondor,Créteil,France;Hôpital Henri Mondor,Créteil,Frankreich;Hôpital Henri Mondor,Créteil,Francia;Hôpital Henri Mondor,Créteil,France;Hôpital Henri Mondor,Créteil,Francia;Hôpital Henri Mondor,Créteil,Frankrijk;Hôpital Henri Mondor,Créteil,França;Hôpital Henri Mondor,Créteil,Франция ;Hôpital Henri Mondor,Créteil,Frankrike
,
Nadine Morineau
Affiliations:
CHD Vendée,La Roche sur Yon,France;CHD Vendée,La Roche sur Yon,Frankreich;CHD Vendée,La Roche sur Yon,Francia;CHD Vendée,La Roche sur Yon,France;CHD Vendée,La Roche sur Yon,Francia;CHD Vendée,La Roche sur Yon,Frankrijk;CHD Vendée,La Roche sur Yon,França;CHD Vendée,La Roche sur Yon,Франция ;CHD Vendée,La Roche sur Yon,Frankrike
,
Loïc Ysebaert
Affiliations:
IUCT Oncopôle,Toulouse,France;IUCT Oncopôle,Toulouse,Frankreich;IUCT Oncopôle,Toulouse,Francia;IUCT Oncopôle,Toulouse,France;IUCT Oncopôle,Toulouse,Francia;IUCT Oncopôle,Toulouse,Frankrijk;IUCT Oncopôle,Toulouse,França;IUCT Oncopôle,Toulouse,Франция ;IUCT Oncopôle,Toulouse,Frankrike
,
Gandhi Damaj
Affiliations:
Institut d'Hématologie de Basse Normandie,Caen,France;Institut d'Hématologie de Basse Normandie,Caen,Frankreich;Institut d'Hématologie de Basse Normandie,Caen,Francia;Institut d'Hématologie de Basse Normandie,Caen,France;Institut d'Hématologie de Basse Normandie,Caen,Francia;Institut d'Hématologie de Basse Normandie,Caen,Frankrijk;Institut d'Hématologie de Basse Normandie,Caen,França;Institut d'Hé
,
Steven Le Gouill
Affiliations:
Centre Hospitalier Universitaire de Nantes,Nantes,France;Centre Hospitalier Universitaire de Nantes,Nantes,Frankreich;Centre Hospitalier Universitaire de Nantes,Nantes,Francia;Centre Hospitalier Universitaire de Nantes,Nantes,France;Centre Hospitalier Universitaire de Nantes,Nantes,Francia;Centre Hospitalier Universitaire de Nantes,Nantes,Frankrijk;Centre Hospitalier Universitaire de Nantes,Nantes
,
Stéphanie Guidez
Affiliations:
Centre Hospitalier Universitaire de Poitiers,Poitiers,France;Centre Hospitalier Universitaire de Poitiers,Poitiers,Frankreich;Centre Hospitalier Universitaire de Poitiers,Poitiers,Francia;Centre Hospitalier Universitaire de Poitiers,Poitiers,France;Centre Hospitalier Universitaire de Poitiers,Poitiers,Francia;Centre Hospitalier Universitaire de Poitiers,Poitiers,Frankrijk;Centre Hospitalier Univer
,
Franck Morschhauser
Affiliations:
CHRU de Lille,Lille,France;CHRU de Lille,Lille,Frankreich;CHRU de Lille,Lille,Francia;CHRU de Lille,Lille,France;CHRU de Lille,Lille,Francia;CHRU de Lille,Lille,Frankrijk;CHRU de Lille,Lille,França;CHRU de Lille,Lille,Франция ;CHRU de Lille,Lille,Frankrike
,
Catherine Thiéblemont
Affiliations:
Hôpital Saint-Louis,Paris,France;Hôpital Saint-Louis,Paris,Frankreich;Hôpital Saint-Louis,Paris,Francia;Hôpital Saint-Louis,Paris,France;Hôpital Saint-Louis,Paris,Francia;Hôpital Saint-Louis,Paris,Frankrijk;Hôpital Saint-Louis,Paris,França;Hôpital Saint-Louis,Paris,Франция ;Hôpital Saint-Louis,Paris,Frankrike
,
Adrien Chauchet
Affiliations:
CHU Jean Minjoz,Besancon,France;CHU Jean Minjoz,Besancon,Frankreich;CHU Jean Minjoz,Besancon,Francia;CHU Jean Minjoz,Besancon,France;CHU Jean Minjoz,Besancon,Francia;CHU Jean Minjoz,Besancon,Frankrijk;CHU Jean Minjoz,Besancon,França;CHU Jean Minjoz,Besancon,Франция ;CHU Jean Minjoz,Besancon,Frankrike
,
Rémy Gressin
Affiliations:
Centre Hospitalier Universitaire Michallon,La Tronche,France;Centre Hospitalier Universitaire Michallon,La Tronche,Frankreich;Centre Hospitalier Universitaire Michallon,La Tronche,Francia;Centre Hospitalier Universitaire Michallon,La Tronche,France;Centre Hospitalier Universitaire Michallon,La Tronche,Francia;Centre Hospitalier Universitaire Michallon,La Tronche,Frankrijk;Centre Hospitalier Univer
,
Fabrice Jardin
Affiliations:
Centre Henri Becquerel,Rouen,France;Centre Henri Becquerel,Rouen,Frankreich;Centre Henri Becquerel,Rouen,Francia;Centre Henri Becquerel,Rouen,France;Centre Henri Becquerel,Rouen,Francia;Centre Henri Becquerel,Rouen,Frankrijk;Centre Henri Becquerel,Rouen,França;Centre Henri Becquerel,Rouen,Франция ;Centre Henri Becquerel,Rouen,Frankrike
,
Christophe Fruchart
Affiliations:
Centre Hospitalier de Dunkerque,Dunkerque,France;Centre Hospitalier de Dunkerque,Dunkerque,Frankreich;Centre Hospitalier de Dunkerque,Dunkerque,Francia;Centre Hospitalier de Dunkerque,Dunkerque,France;Centre Hospitalier de Dunkerque,Dunkerque,Francia;Centre Hospitalier de Dunkerque,Dunkerque,Frankrijk;Centre Hospitalier de Dunkerque,Dunkerque,França;Centre Hospitalier de Dunkerque,Dunkerque,Франци
,
Gaelle Labouré
Affiliations:
Centre Hospitalier de Libourne,Libourne,France;Centre Hospitalier de Libourne,Libourne,Frankreich;Centre Hospitalier de Libourne,Libourne,Francia;Centre Hospitalier de Libourne,Libourne,France;Centre Hospitalier de Libourne,Libourne,Francia;Centre Hospitalier de Libourne,Libourne,Frankrijk;Centre Hospitalier de Libourne,Libourne,França;Centre Hospitalier de Libourne,Libourne,Франция ;Centre Hospit
,
Ludovic Fouillet
Affiliations:
Institut de Cancérologie Lucien Neuwirth,Saint-Priest-en-Jarez,France;Institut de Cancérologie Lucien Neuwirth,Saint-Priest-en-Jarez,Frankreich;Institut de Cancérologie Lucien Neuwirth,Saint-Priest-en-Jarez,Francia;Institut de Cancérologie Lucien Neuwirth,Saint-Priest-en-Jarez,France;Institut de Cancérologie Lucien Neuwirth,Saint-Priest-en-Jarez,Francia;Institut de Cancérologie Lucien Neuwirth,Sai
,
Pauline Lionne-Huyghe
Affiliations:
Centre Hospitalier d'Arras,Arras,France;Centre Hospitalier d'Arras,Arras,Frankreich;Centre Hospitalier d'Arras,Arras,Francia;Centre Hospitalier d'Arras,Arras,France;Centre Hospitalier d'Arras,Arras,Francia;Centre Hospitalier d'Arras,Arras,Frankrijk;Centre Hospitalier d'Arras,Arras,França;Centre Hospitalier d'Arras,Arras,Франция ;Centre Hospitalier d'Arras,Arras,Frankrike
,
Antoine Bonnet
Affiliations:
Centre Hospitalier Bretagne Atlantique,Vannes,France;Centre Hospitalier Bretagne Atlantique,Vannes,Frankreich;Centre Hospitalier Bretagne Atlantique,Vannes,Francia;Centre Hospitalier Bretagne Atlantique,Vannes,France;Centre Hospitalier Bretagne Atlantique,Vannes,Francia;Centre Hospitalier Bretagne Atlantique,Vannes,Frankrijk;Centre Hospitalier Bretagne Atlantique,Vannes,França;Centre Hospitalier B
,
Laure Lebras
Affiliations:
Centre Léon Bérard,Lyon,France;Centre Léon Bérard,Lyon,Frankreich;Centre Léon Bérard,Lyon,Francia;Centre Léon Bérard,Lyon,France;Centre Léon Bérard,Lyon,Francia;Centre Léon Bérard,Lyon,Frankrijk;Centre Léon Bérard,Lyon,França;Centre Léon Bérard,Lyon,Франция ;Centre Léon Bérard,Lyon,Frankrike
,
Sandy Amorim
Affiliations:
Hôpital Saint-Vincent-de-Paul,Lille,France;Hôpital Saint-Vincent-de-Paul,Lille,Frankreich;Hôpital Saint-Vincent-de-Paul,Lille,Francia;Hôpital Saint-Vincent-de-Paul,Lille,France;Hôpital Saint-Vincent-de-Paul,Lille,Francia;Hôpital Saint-Vincent-de-Paul,Lille,Frankrijk;Hôpital Saint-Vincent-de-Paul,Lille,França;Hôpital Saint-Vincent-de-Paul,Lille,Франция ;Hôpital Saint-Vincent-de-Paul,Lille,Frankrike
,
Cécile Leyronnas
Affiliations:
Groupe Hospitalier Mutualiste de Grenoble,Grenoble,France;Groupe Hospitalier Mutualiste de Grenoble,Grenoble,Frankreich;Groupe Hospitalier Mutualiste de Grenoble,Grenoble,Francia;Groupe Hospitalier Mutualiste de Grenoble,Grenoble,France;Groupe Hospitalier Mutualiste de Grenoble,Grenoble,Francia;Groupe Hospitalier Mutualiste de Grenoble,Grenoble,Frankrijk;Groupe Hospitalier Mutualiste de Grenoble,G
,
Gaëlle Olivier
Affiliations:
Centre Hospitalier de Niort,Niort,France;Centre Hospitalier de Niort,Niort,Frankreich;Centre Hospitalier de Niort,Niort,Francia;Centre Hospitalier de Niort,Niort,France;Centre Hospitalier de Niort,Niort,Francia;Centre Hospitalier de Niort,Niort,Frankrijk;Centre Hospitalier de Niort,Niort,França;Centre Hospitalier de Niort,Niort,Франция ;Centre Hospitalier de Niort,Niort,Frankrike
,
Romain Guieze
Affiliations:
CHU de Clermont-Ferrand,Clermont-Ferrand,France;CHU de Clermont-Ferrand,Clermont-Ferrand,Frankreich;CHU de Clermont-Ferrand,Clermont-Ferrand,Francia;CHU de Clermont-Ferrand,Clermont-Ferrand,France;CHU de Clermont-Ferrand,Clermont-Ferrand,Francia;CHU de Clermont-Ferrand,Clermont-Ferrand,Frankrijk;CHU de Clermont-Ferrand,Clermont-Ferrand,França;CHU de Clermont-Ferrand,Clermont-Ferrand,Франция ;CHU d
,
Thierry Lamy
Affiliations:
CHU Pontchaillou,Rennes,France;CHU Pontchaillou,Rennes,Frankreich;CHU Pontchaillou,Rennes,Francia;CHU Pontchaillou,Rennes,France;CHU Pontchaillou,Rennes,Francia;CHU Pontchaillou,Rennes,Frankrijk;CHU Pontchaillou,Rennes,França;CHU Pontchaillou,Rennes,Франция ;CHU Pontchaillou,Rennes,Frankrike
,
Vincent Launay
Affiliations:
Centre Hospitalier Yves Le Foll,Saint-Brieuc,France;Centre Hospitalier Yves Le Foll,Saint-Brieuc,Frankreich;Centre Hospitalier Yves Le Foll,Saint-Brieuc,Francia;Centre Hospitalier Yves Le Foll,Saint-Brieuc,France;Centre Hospitalier Yves Le Foll,Saint-Brieuc,Francia;Centre Hospitalier Yves Le Foll,Saint-Brieuc,Frankrijk;Centre Hospitalier Yves Le Foll,Saint-Brieuc,França;Centre Hospitalier Yves Le
,
Bernard Drenou
Affiliations:
Groupe Hospitalier Mulhouse et Sud Alsace,Mulhouse,France;Groupe Hospitalier Mulhouse et Sud Alsace,Mulhouse,Frankreich;Groupe Hospitalier Mulhouse et Sud Alsace,Mulhouse,Francia;Groupe Hospitalier Mulhouse et Sud Alsace,Mulhouse,France;Groupe Hospitalier Mulhouse et Sud Alsace,Mulhouse,Francia;Groupe Hospitalier Mulhouse et Sud Alsace,Mulhouse,Frankrijk;Groupe Hospitalier Mulhouse et Sud Alsace,M
,
Olivier Fitoussi
Affiliations:
Polyclinique Bordeaux Nord Aquitaine,Bordeaux,France;Polyclinique Bordeaux Nord Aquitaine,Bordeaux,Frankreich;Polyclinique Bordeaux Nord Aquitaine,Bordeaux,Francia;Polyclinique Bordeaux Nord Aquitaine,Bordeaux,France;Polyclinique Bordeaux Nord Aquitaine,Bordeaux,Francia;Polyclinique Bordeaux Nord Aquitaine,Bordeaux,Frankrijk;Polyclinique Bordeaux Nord Aquitaine,Bordeaux,França;Polyclinique Bordeau
,
Laurence Detourmignies
Affiliations:
Centre Hospitalier de Roubaix,Roubaix,France;Centre Hospitalier de Roubaix,Roubaix,Frankreich;Centre Hospitalier de Roubaix,Roubaix,Francia;Centre Hospitalier de Roubaix,Roubaix,France;Centre Hospitalier de Roubaix,Roubaix,Francia;Centre Hospitalier de Roubaix,Roubaix,Frankrijk;Centre Hospitalier de Roubaix,Roubaix,França;Centre Hospitalier de Roubaix,Roubaix,Франция ;Centre Hospitalier de Roubaix
,
Julie Abraham
Affiliations:
Centre Hospitalier Universitaire de Limoges,Limoges,France;Centre Hospitalier Universitaire de Limoges,Limoges,Frankreich;Centre Hospitalier Universitaire de Limoges,Limoges,Francia;Centre Hospitalier Universitaire de Limoges,Limoges,France;Centre Hospitalier Universitaire de Limoges,Limoges,Francia;Centre Hospitalier Universitaire de Limoges,Limoges,Frankrijk;Centre Hospitalier Universitaire de L
,
Carole Soussain
Affiliations:
Institut Curie,Saint-Cloud,France;Institut Curie,Saint-Cloud,Frankreich;Institut Curie,Saint-Cloud,Francia;Institut Curie,Saint-Cloud,France;Institut Curie,Saint-Cloud,Francia;Institut Curie,Saint-Cloud,Frankrijk;Institut Curie,Saint-Cloud,França;Institut Curie,Saint-Cloud,Франция ;Institut Curie,Saint-Cloud,Frankrike
,
Florence Lachenal
Affiliations:
Centre Hospitalier Pierre Oudot,Bourgoin-Jallieu,France;Centre Hospitalier Pierre Oudot,Bourgoin-Jallieu,Frankreich;Centre Hospitalier Pierre Oudot,Bourgoin-Jallieu,Francia;Centre Hospitalier Pierre Oudot,Bourgoin-Jallieu,France;Centre Hospitalier Pierre Oudot,Bourgoin-Jallieu,Francia;Centre Hospitalier Pierre Oudot,Bourgoin-Jallieu,Frankrijk;Centre Hospitalier Pierre Oudot,Bourgoin-Jallieu,França
,
Patrick Fogarty
Affiliations:
LYSARC,Pierre-Benite,France;LYSARC,Pierre-Benite,Frankreich;LYSARC,Pierre-Benite,Francia;LYSARC,Pierre-Benite,France;LYSARC,Pierre-Benite,Francia;LYSARC,Pierre-Benite,Frankrijk;LYSARC,Pierre-Benite,França;LYSARC,Pierre-Benite,Франция ;LYSARC,Pierre-Benite,Frankrike
,
Pascale Cony-Makhoul
Affiliations:
LYSARC,Pierre-Benite,France;LYSARC,Pierre-Benite,Frankreich;LYSARC,Pierre-Benite,Francia;LYSARC,Pierre-Benite,France;LYSARC,Pierre-Benite,Francia;LYSARC,Pierre-Benite,Frankrijk;LYSARC,Pierre-Benite,França;LYSARC,Pierre-Benite,Франция ;LYSARC,Pierre-Benite,Frankrike
,
Adeline Bernier
Affiliations:
LYSARC,Pierre-Benite,France;LYSARC,Pierre-Benite,Frankreich;LYSARC,Pierre-Benite,Francia;LYSARC,Pierre-Benite,France;LYSARC,Pierre-Benite,Francia;LYSARC,Pierre-Benite,Frankrijk;LYSARC,Pierre-Benite,França;LYSARC,Pierre-Benite,Франция ;LYSARC,Pierre-Benite,Frankrike
,
Sandra Le Guyader-Peyrou
Affiliations:
Université de Bordeaux,Bordeaux,France;Université de Bordeaux,Bordeaux,Frankreich;Université de Bordeaux,Bordeaux,Francia;Université de Bordeaux,Bordeaux,France;Université de Bordeaux,Bordeaux,Francia;Université de Bordeaux,Bordeaux,Frankrijk;Université de Bordeaux,Bordeaux,França;Université de Bordeaux,Bordeaux,Франция ;Université de Bordeaux,Bordeaux,Frankrike
,
Alain Monnereau
Affiliations:
Université de Bordeaux,Bordeaux,France;Université de Bordeaux,Bordeaux,Frankreich;Université de Bordeaux,Bordeaux,Francia;Université de Bordeaux,Bordeaux,France;Université de Bordeaux,Bordeaux,Francia;Université de Bordeaux,Bordeaux,Frankrijk;Université de Bordeaux,Bordeaux,França;Université de Bordeaux,Bordeaux,Франция ;Université de Bordeaux,Bordeaux,Frankrike
,
Frédéric Boissard
Affiliations:
Roche - F.Hoffman-La Roche Ltd,Basel,Suisse;Roche - F.Hoffman-La Roche Ltd,Basel,Schweiz;Roche - F.Hoffman-La Roche Ltd,Basel,Svizzera;Roche - F.Hoffman-La Roche Ltd,Basel,Switzerland;Roche - F.Hoffman-La Roche Ltd,Basel,Suiza;Roche - F.Hoffman-La Roche Ltd,Basel,Zwitserland;Roche - F.Hoffman-La Roche Ltd,Basel,Suíça;Roche - F.Hoffman-La Roche Ltd,Basel,Швейцария ;Roche - F.Hoffman-La Roche Ltd,Ba
Cédric Rossi
Affiliations:
Centre Hospitalier Universitaire Francois Mitterand,Dijon,France;Centre Hospitalier Universitaire Francois Mitterand,Dijon,Frankreich;Centre Hospitalier Universitaire Francois Mitterand,Dijon,Francia;Centre Hospitalier Universitaire Francois Mitterand,Dijon,France;Centre Hospitalier Universitaire Francois Mitterand,Dijon,Francia;Centre Hospitalier Universitaire Francois Mitterand,Dijon,Frankrijk;C
(Abstract release date: 05/12/22) EHA Library. Ghesquieres H. 06/10/22; 358045; P1186
Herve Ghesquieres
Herve Ghesquieres
Contributions
Abstract
Presentation during EHA2022: All (e)Poster presentations will be made available as of Friday, June 10, 2022 (09:00 CEST) and will be accessible for on-demand viewing until Monday, August 15, 2022 on the Congress platform.

Abstract: P1186

Type: Poster presentation

Session title: Aggressive Non-Hodgkin lymphoma - Clinical

Background

In France, there were an estimated 18.000 incident lymphoma cases in 2018. Currently, most of the knowledge comes from clinical trials (CT), with stringent inclusion criteria and poor representativeness. Real world data (RWD) is essential to complement CT data, but major challenges such as feasibility and data quality remain. In this context, the REal world dAta in LYmphoma and Survival in Adults (REALYSA) multicentric prospective cohort started in 2018 (NCT03869619), with a recruitment objective of 6000 patients and a 9-year follow-up (FU).

Aims

The aims of this study are (i) to evaluate the capacity of a real-world program to provide high-quality data that translate into meaningful clinical endpoints, and (ii) to describe the demographic and clinical characteristics as well as therapeutic management and treatment effectiveness of 1st line (1L) DLBCL patients.

Methods

Patients diagnosed with 7 histological lymphoma subtypes are included in REALYSA at diagnosis after signing informed consent. Patients receive standard routine care. Data collection includes demographic, clinical, quality of life and epidemiological data at inclusion and every 6 to 12 months. A biobank is also constituted. A strong data validation system inspired from clinical research standards, including care pathway visualisation tools, is regularly running. Meaningful real-life endpoints were derived, such as end of treatment (EoT) evaluation and event-free survival (EFS).

We present here the results of a proof-of-concept analysis for REALYSA patients with a DLBCL diagnosis and who received a 1L treatment.

Results

Thirty-five hospitals/clinics are currently participating to REALYSA across France. As of Jan 31st 2022, 1217 patients with DLBCL were included in REALYSA with a mean number of 60 patients per month; 645 epidemiological questionnaires were collected; and there were more than 1500 samples in the biobank.

The analysis was conducted on 645 DLBCL patients included in REALYSA before March 31st 2021. Median age was 66.3 years [54-75]. Most patients were male (344 ; 53.3%), with advanced-stage disease (Ann-Arbor stage III/IV for 472 patients (73.3%)), extra-nodal locations (499 ; 77.4%) and elevated LDH level (402 ; 64.0%). The international prognostic index was 2 to 5 for 486 patients (76.2%). Treatments received at 1L were R-CHOP (482; 74.7%), R-miniCHOP (86; 13.3%), high dose anthracycline-based regimen (62; 9.6%) and non-anthracycline based regimen (15; 2.3%). Among patients with EoT evaluation done (603), 483 (80.1%) had a complete response, 51 (8.5%) a partial response, 7 (1.2%) a stable disease and 62 (10.3%) a progressive disease. Of note, EoT evaluation was performed by PET/scan for 92% of patients. Median FU was 9.9 months [4.5-17.2]. Results for effectiveness at 12 months were: (i) EFS of 77.9% [95% CI 73.8-81.4]; (ii) PFS of 79.7% [75.6-83.1]; and (iii) overall survival of 90.0% [86.5-92.5]. With the limitation of the short FU, and using backward stepwise regression model, we confirmed that EFS was associated with age, ECOG PS, LDH level and bulk disease.   

Conclusion

This analysis showed that REALYSA, the first nationwide real-life cohort on lymphoma, is able to provide high-quality data, with results for 1L DLBCL patients consistent with the literature, including recent phase 3 trials. These data will be useful for numerous purposes, including a better characterization of lymphoma population in France (clinic, epidemiology, biology), as well as innovative study designs (e.g. new outcome endpoints, synthetic control arm).

Keyword(s): Diffuse large B cell lymphoma, Outcome measurement

Presentation during EHA2022: All (e)Poster presentations will be made available as of Friday, June 10, 2022 (09:00 CEST) and will be accessible for on-demand viewing until Monday, August 15, 2022 on the Congress platform.

Abstract: P1186

Type: Poster presentation

Session title: Aggressive Non-Hodgkin lymphoma - Clinical

Background

In France, there were an estimated 18.000 incident lymphoma cases in 2018. Currently, most of the knowledge comes from clinical trials (CT), with stringent inclusion criteria and poor representativeness. Real world data (RWD) is essential to complement CT data, but major challenges such as feasibility and data quality remain. In this context, the REal world dAta in LYmphoma and Survival in Adults (REALYSA) multicentric prospective cohort started in 2018 (NCT03869619), with a recruitment objective of 6000 patients and a 9-year follow-up (FU).

Aims

The aims of this study are (i) to evaluate the capacity of a real-world program to provide high-quality data that translate into meaningful clinical endpoints, and (ii) to describe the demographic and clinical characteristics as well as therapeutic management and treatment effectiveness of 1st line (1L) DLBCL patients.

Methods

Patients diagnosed with 7 histological lymphoma subtypes are included in REALYSA at diagnosis after signing informed consent. Patients receive standard routine care. Data collection includes demographic, clinical, quality of life and epidemiological data at inclusion and every 6 to 12 months. A biobank is also constituted. A strong data validation system inspired from clinical research standards, including care pathway visualisation tools, is regularly running. Meaningful real-life endpoints were derived, such as end of treatment (EoT) evaluation and event-free survival (EFS).

We present here the results of a proof-of-concept analysis for REALYSA patients with a DLBCL diagnosis and who received a 1L treatment.

Results

Thirty-five hospitals/clinics are currently participating to REALYSA across France. As of Jan 31st 2022, 1217 patients with DLBCL were included in REALYSA with a mean number of 60 patients per month; 645 epidemiological questionnaires were collected; and there were more than 1500 samples in the biobank.

The analysis was conducted on 645 DLBCL patients included in REALYSA before March 31st 2021. Median age was 66.3 years [54-75]. Most patients were male (344 ; 53.3%), with advanced-stage disease (Ann-Arbor stage III/IV for 472 patients (73.3%)), extra-nodal locations (499 ; 77.4%) and elevated LDH level (402 ; 64.0%). The international prognostic index was 2 to 5 for 486 patients (76.2%). Treatments received at 1L were R-CHOP (482; 74.7%), R-miniCHOP (86; 13.3%), high dose anthracycline-based regimen (62; 9.6%) and non-anthracycline based regimen (15; 2.3%). Among patients with EoT evaluation done (603), 483 (80.1%) had a complete response, 51 (8.5%) a partial response, 7 (1.2%) a stable disease and 62 (10.3%) a progressive disease. Of note, EoT evaluation was performed by PET/scan for 92% of patients. Median FU was 9.9 months [4.5-17.2]. Results for effectiveness at 12 months were: (i) EFS of 77.9% [95% CI 73.8-81.4]; (ii) PFS of 79.7% [75.6-83.1]; and (iii) overall survival of 90.0% [86.5-92.5]. With the limitation of the short FU, and using backward stepwise regression model, we confirmed that EFS was associated with age, ECOG PS, LDH level and bulk disease.   

Conclusion

This analysis showed that REALYSA, the first nationwide real-life cohort on lymphoma, is able to provide high-quality data, with results for 1L DLBCL patients consistent with the literature, including recent phase 3 trials. These data will be useful for numerous purposes, including a better characterization of lymphoma population in France (clinic, epidemiology, biology), as well as innovative study designs (e.g. new outcome endpoints, synthetic control arm).

Keyword(s): Diffuse large B cell lymphoma, Outcome measurement

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