Contributions
Abstract: EP831
Type: E-Poster Presentation
Session title: Infections in hematology (incl. supportive care/therapy)
Background
Patients with hematologic malignancies are at high risk for infections caused by antibiotic resistant gram-negative bacteria.
Aims
This study aimed to evaluate the characteristics, antibiotic resistance patterns and prognosis of infections due to multidrug resistant (MDR) gram-negative bacteria in patients with hematologic malignancy.
Methods
Data were collected retrospectively and concerned all infections caused by MDR gram-negative in patients with hematologic malignancy from January 2010 and November 2019 in our department of hematology. Data analysis was initially performed using the univariate analysis (chi² and student test). Then, risk factors with a P<0.05 were included in the binary logistic regression model to determine the independent risk factors of mortality.
Results
In Total, 512 patients developed infections with 83 MDR gram-negative strains detected in 80 patients, most of them (68 patients) have an acute leukemia. The MDR gram-negative infection occurred in 58 patients with uncontrolled disease, and the majority of them occurred in the presence of severe neutropenia (62 episodes/74.7%). Bloodstream infection (BSI) (57episodes/68.7%) was the most common infection types. Klebsiella pneumonia was the most common Gram-negative isolates (44 episodes/53%). Complications occurred in 44 (53%) episodes. In 41 episodes, patients received an appropriate antibiotherapy. The isolated MDR gram-negative bacteria exhibited sensitivity to amikacin in 17%, imipenem in 32.5% (three isolates were resistant to colistin). Twenty-two patients died during gram-negative MDR infections. The independent risk factors influencing mortality was : qSOFA>=2. (p : 0.003) (table 1).
Conclusion
The burden of infections due to gram-negative MDR bacteria is considerably high in patients with hematologic malignancy, with Klebsiella pneumonia being the most predominant causative pathogen. Mortality in these immunocompromised patients remains high and more effort is needed to improve the prognosis of these individuals.
Keyword(s): Hematological malignancy, Infection
Abstract: EP831
Type: E-Poster Presentation
Session title: Infections in hematology (incl. supportive care/therapy)
Background
Patients with hematologic malignancies are at high risk for infections caused by antibiotic resistant gram-negative bacteria.
Aims
This study aimed to evaluate the characteristics, antibiotic resistance patterns and prognosis of infections due to multidrug resistant (MDR) gram-negative bacteria in patients with hematologic malignancy.
Methods
Data were collected retrospectively and concerned all infections caused by MDR gram-negative in patients with hematologic malignancy from January 2010 and November 2019 in our department of hematology. Data analysis was initially performed using the univariate analysis (chi² and student test). Then, risk factors with a P<0.05 were included in the binary logistic regression model to determine the independent risk factors of mortality.
Results
In Total, 512 patients developed infections with 83 MDR gram-negative strains detected in 80 patients, most of them (68 patients) have an acute leukemia. The MDR gram-negative infection occurred in 58 patients with uncontrolled disease, and the majority of them occurred in the presence of severe neutropenia (62 episodes/74.7%). Bloodstream infection (BSI) (57episodes/68.7%) was the most common infection types. Klebsiella pneumonia was the most common Gram-negative isolates (44 episodes/53%). Complications occurred in 44 (53%) episodes. In 41 episodes, patients received an appropriate antibiotherapy. The isolated MDR gram-negative bacteria exhibited sensitivity to amikacin in 17%, imipenem in 32.5% (three isolates were resistant to colistin). Twenty-two patients died during gram-negative MDR infections. The independent risk factors influencing mortality was : qSOFA>=2. (p : 0.003) (table 1).
Conclusion
The burden of infections due to gram-negative MDR bacteria is considerably high in patients with hematologic malignancy, with Klebsiella pneumonia being the most predominant causative pathogen. Mortality in these immunocompromised patients remains high and more effort is needed to improve the prognosis of these individuals.
Keyword(s): Hematological malignancy, Infection