Contributions
Abstract: EP1344
Type: E-Poster Presentation
Session title: Transfusion medicine
Background
Regular blood donation depletes Iron. Uncompensated iron loss may eventually lead to iron deficiency anaemia. Approximately 25 to 35% of blood donors who donate blood 3-4 times yearly become iron depleted. Iron deficiency anaemia is an important limiting factor to a sustainable supply of blood units especially in LMIC. Blood transfusion practice in Nigeria is poorly developed and structured with paucity of non-remunerated blood donors and high rate of donor deferrals resulting from transfusion transmitted infections and low haemoglobin levels. There is need to protect the donor pool to meet the blood needs in resource poor countries.
Aims
We aimed to assess the effect of daily supplementation of iron using Ranferon-12 on RBC indices, Iron level, ferritin level and Hb recovery in blood donors in Nigeria.
Methods
We carried out an interventional study at the University of Nigeria Teaching Hospital blood transfusion center from March to July 2020. Study participants (blood donors) were randomized into two groups. Group A (control group): blood donor who did not donate a unit of blood and did not receive iron supplementation. Group B (experimental group): blood donors who donated a unit of blood and received iron supplementation (Daily Ranferon capsules containing 100mg elemental iron; iron fumarate) and 100mg of tablet vitamin C for 6 weeks.
The primary outcome measure were levels of Haemoglobin (Hb), Packed cell volume (PCV), red cell indices ( Mythic 22 haematology analyzer) Serum ferritin (Abbott 1000isr ), Total body iron Beckman Coulter AU680) Soluble transferrin receptor (sTfR), and percentage iron saturation was calculated
Secondary outcome measure were adherence/compliance and tolerance to daily iron supplementation using Ranferon using Modified Morisky scale and investigator designed pretested, pre validated questionnaire, respectively.
The study was approved by UNTH REC with ethical approval number NHREC/05/01/2008B-FWA00002458-1RB00002323
Results
A total of 90 blood donors participated in the study, 30 was randomized to the control group and 60 to the experimental group. Majority (52.2%) were less than 24 years and Most (95.6%) were males.
Only the mean difference in mean cell haemoglobin concentration (MCHC) and soluble transferrin receptor (sTfR) before and after iron supplementation were statistically significance with p values of 0.030 and<0.001, respectively.
The relationship between only the mean difference in red cell count (RCC), packed cell volume PCV), red cell indices, % iron saturation and soluble transferrin receptor (sTfR) and iron supplementation were statistically significant with p values <0.001.
Percentage recovery of the parameters after 6 weeks of daily Ranferon range from 89 to > 100%. The percentage recovery of Hb level was 89% while others were more than 89%.
Six participants (10%) were iron replete before the intervention with daly Ranferon with only one participant (1%) remaining iron replete after the intervention.
Only one participant (1.7%) reported GIT intolerance while on daily iron supplementationwith Ranferon. Majority, (95%), (93.3%) responded NO to “the participant takes less/more medicine than instructed” and NEVER to “The participant alters the dose of his/her medicine.”
Conclusion
Iron supplementation using Ranferon capsule daily for 6 weeks enhanced the recovery of haemoglobin (Hb), red cell indices post blood donation with attainment of benchmark haemoglobin levels for donation.
Keyword(s): Blood transfusion, Iron deficiency anemia
Abstract: EP1344
Type: E-Poster Presentation
Session title: Transfusion medicine
Background
Regular blood donation depletes Iron. Uncompensated iron loss may eventually lead to iron deficiency anaemia. Approximately 25 to 35% of blood donors who donate blood 3-4 times yearly become iron depleted. Iron deficiency anaemia is an important limiting factor to a sustainable supply of blood units especially in LMIC. Blood transfusion practice in Nigeria is poorly developed and structured with paucity of non-remunerated blood donors and high rate of donor deferrals resulting from transfusion transmitted infections and low haemoglobin levels. There is need to protect the donor pool to meet the blood needs in resource poor countries.
Aims
We aimed to assess the effect of daily supplementation of iron using Ranferon-12 on RBC indices, Iron level, ferritin level and Hb recovery in blood donors in Nigeria.
Methods
We carried out an interventional study at the University of Nigeria Teaching Hospital blood transfusion center from March to July 2020. Study participants (blood donors) were randomized into two groups. Group A (control group): blood donor who did not donate a unit of blood and did not receive iron supplementation. Group B (experimental group): blood donors who donated a unit of blood and received iron supplementation (Daily Ranferon capsules containing 100mg elemental iron; iron fumarate) and 100mg of tablet vitamin C for 6 weeks.
The primary outcome measure were levels of Haemoglobin (Hb), Packed cell volume (PCV), red cell indices ( Mythic 22 haematology analyzer) Serum ferritin (Abbott 1000isr ), Total body iron Beckman Coulter AU680) Soluble transferrin receptor (sTfR), and percentage iron saturation was calculated
Secondary outcome measure were adherence/compliance and tolerance to daily iron supplementation using Ranferon using Modified Morisky scale and investigator designed pretested, pre validated questionnaire, respectively.
The study was approved by UNTH REC with ethical approval number NHREC/05/01/2008B-FWA00002458-1RB00002323
Results
A total of 90 blood donors participated in the study, 30 was randomized to the control group and 60 to the experimental group. Majority (52.2%) were less than 24 years and Most (95.6%) were males.
Only the mean difference in mean cell haemoglobin concentration (MCHC) and soluble transferrin receptor (sTfR) before and after iron supplementation were statistically significance with p values of 0.030 and<0.001, respectively.
The relationship between only the mean difference in red cell count (RCC), packed cell volume PCV), red cell indices, % iron saturation and soluble transferrin receptor (sTfR) and iron supplementation were statistically significant with p values <0.001.
Percentage recovery of the parameters after 6 weeks of daily Ranferon range from 89 to > 100%. The percentage recovery of Hb level was 89% while others were more than 89%.
Six participants (10%) were iron replete before the intervention with daly Ranferon with only one participant (1%) remaining iron replete after the intervention.
Only one participant (1.7%) reported GIT intolerance while on daily iron supplementationwith Ranferon. Majority, (95%), (93.3%) responded NO to “the participant takes less/more medicine than instructed” and NEVER to “The participant alters the dose of his/her medicine.”
Conclusion
Iron supplementation using Ranferon capsule daily for 6 weeks enhanced the recovery of haemoglobin (Hb), red cell indices post blood donation with attainment of benchmark haemoglobin levels for donation.
Keyword(s): Blood transfusion, Iron deficiency anemia