Contributions
Abstract: EP1022
Type: E-Poster Presentation
Session title: Myeloma and other monoclonal gammopathies - Clinical
Background
The occurrence of two or more cases of multiple myeloma (MM) in the same family has been decribed in several countries whereas population-based studies on MM and other malignancies beyond first-degree relatives are scarce.
Aims
We wanted to investigate the risk of multiple myeloma (MM) and other malignancies in first- and second-degree relatives of MM patients based on information from the Cancer Registry of Norway (CRN).
Methods
All cases of MM diagnosed between January 1, 1982 and December 31, 2013 were retrieved. Population based control probands were retrieved in 4:1 and matched by year of birth, sex and county of residence. First-degree relatives for a given proband consisted of parents, siblings, and children. Second-degree relatives consisted of grand-parents, uncles and aunts, nephews and nieces, and grandchildren.
We used a Cox proportional hazards model to estimate the risk, denoted by the hazard ratio (HR), for MM and other malignancies in relatives of MM patients versus relatives of controls. An individual became at risk for a given cancer diagnosis after the date of birth or at the start of cancer registration (1953). Follow-up ended at the date of diagnosis of the cancer of interest, date of emigration, date of death, or end of study December 31, 2015. We adjusted for sex of the relatives, sex of the proband, and 15-y calendar period of birth in all analyses. The association between exposure and a diagnosis of MM was evaluated in all relatives. For MM, associations in subtypes of first- and second-degree were assessed. HR with 95% confidence intervals not including one were considered statistically significant.
Results
We included 7487 of 10035 MM patients diagnosed between January 1, 1982 and December 31, 2013 and 26 511 matched controls. The actual study population of relatives consisted 65 168 relatives of MM-patients and 223 643 relatives of matched controls.
Table 1. Hazard ratios for MM in relatives of MM patients vs. relatives of controls
| Cases‡ | HR† (95% CI) |
All relatives | 101/182 | 1.89(1.40-2.57)* |
All first-degree relatives | 91/167 | 1.89(1.37-2.61)* |
Offspring | 31/49 | 1.90 (1.20-2.98)* |
Siblings | 17/27 | 2.29 (1.09-4.84)* |
|
|
|
Parents | 43/91 | 1.77 (1.23-2.55)* |
All second-degree relatives | 10/15 | 1.99(0.86-4.57) |
Grandchildren | 1/4 | 0.68 (0.07-6.20) |
Grandparents | 1/4 | 0.81 (0.09-7.31) |
|
|
|
Uncles/aunts | 3/4 | 2.25 (0.53-9.63) |
Nieces/nephews | 5/3 | 4.76 (1.19-18.9)* |
|
|
|
* †Adusted for sex of the relatives, sex of the proband and 15y calendar period of birth,‡ Cases in 65 168 relatives of MM patients/cases in 223 643 relatives of controls,* 95% confidence interval not including one
First-degree relative of MM patients had approximately 2-fold increased risk for a MM diagnosis.
In second-degree relatives of MM-patients, no overall significant association with an MM diagnosis was observed. However, for nieces or nephews of MM patients, a significant association was found.
Conclusion
Overall, being a first-degree relative of MM patients was associated an approximately 2-fold increased risk for acquiring a MM diagnosis compared to relatives of controls. In second-degree relatives of MM-patients, no overall significant association with an MM diagnosis was observed. This was also true for subgroups, except for nieces or nephews of MM patients who had an icreased risk based on small numbers.
Keyword(s): Epidemiology, Familial, Multiple myeloma
Abstract: EP1022
Type: E-Poster Presentation
Session title: Myeloma and other monoclonal gammopathies - Clinical
Background
The occurrence of two or more cases of multiple myeloma (MM) in the same family has been decribed in several countries whereas population-based studies on MM and other malignancies beyond first-degree relatives are scarce.
Aims
We wanted to investigate the risk of multiple myeloma (MM) and other malignancies in first- and second-degree relatives of MM patients based on information from the Cancer Registry of Norway (CRN).
Methods
All cases of MM diagnosed between January 1, 1982 and December 31, 2013 were retrieved. Population based control probands were retrieved in 4:1 and matched by year of birth, sex and county of residence. First-degree relatives for a given proband consisted of parents, siblings, and children. Second-degree relatives consisted of grand-parents, uncles and aunts, nephews and nieces, and grandchildren.
We used a Cox proportional hazards model to estimate the risk, denoted by the hazard ratio (HR), for MM and other malignancies in relatives of MM patients versus relatives of controls. An individual became at risk for a given cancer diagnosis after the date of birth or at the start of cancer registration (1953). Follow-up ended at the date of diagnosis of the cancer of interest, date of emigration, date of death, or end of study December 31, 2015. We adjusted for sex of the relatives, sex of the proband, and 15-y calendar period of birth in all analyses. The association between exposure and a diagnosis of MM was evaluated in all relatives. For MM, associations in subtypes of first- and second-degree were assessed. HR with 95% confidence intervals not including one were considered statistically significant.
Results
We included 7487 of 10035 MM patients diagnosed between January 1, 1982 and December 31, 2013 and 26 511 matched controls. The actual study population of relatives consisted 65 168 relatives of MM-patients and 223 643 relatives of matched controls.
Table 1. Hazard ratios for MM in relatives of MM patients vs. relatives of controls
| Cases‡ | HR† (95% CI) |
All relatives | 101/182 | 1.89(1.40-2.57)* |
All first-degree relatives | 91/167 | 1.89(1.37-2.61)* |
Offspring | 31/49 | 1.90 (1.20-2.98)* |
Siblings | 17/27 | 2.29 (1.09-4.84)* |
|
|
|
Parents | 43/91 | 1.77 (1.23-2.55)* |
All second-degree relatives | 10/15 | 1.99(0.86-4.57) |
Grandchildren | 1/4 | 0.68 (0.07-6.20) |
Grandparents | 1/4 | 0.81 (0.09-7.31) |
|
|
|
Uncles/aunts | 3/4 | 2.25 (0.53-9.63) |
Nieces/nephews | 5/3 | 4.76 (1.19-18.9)* |
|
|
|
* †Adusted for sex of the relatives, sex of the proband and 15y calendar period of birth,‡ Cases in 65 168 relatives of MM patients/cases in 223 643 relatives of controls,* 95% confidence interval not including one
First-degree relative of MM patients had approximately 2-fold increased risk for a MM diagnosis.
In second-degree relatives of MM-patients, no overall significant association with an MM diagnosis was observed. However, for nieces or nephews of MM patients, a significant association was found.
Conclusion
Overall, being a first-degree relative of MM patients was associated an approximately 2-fold increased risk for acquiring a MM diagnosis compared to relatives of controls. In second-degree relatives of MM-patients, no overall significant association with an MM diagnosis was observed. This was also true for subgroups, except for nieces or nephews of MM patients who had an icreased risk based on small numbers.
Keyword(s): Epidemiology, Familial, Multiple myeloma