Contributions
Abstract: PB1832
Type: Publication Only
Session title: Thrombosis and vascular biology - Biology & Translational Research
Background
Plasminogen deficiency is a rare condition with autosomal recessive inheritance. Severe hypoplasminogenemia is associated with ‘ligneous’ lesions on each mucous membranes especialy eye, ear, mouth, pharynx, respiratory and female genital tract; cervix and endometrium. Furthermore, plasminogen deficient women complained from infertility. These kind of patient's diagnosis remained elusive for years.
Aims
We want to share this young women in order to take attention and form a greater familiarity with the clinical and histopathologic features of this condition among gynecologists.
Methods
Data from the files of a 32 year -old nulliparous young woman with intractable gingivitis and dental problems and a history of persistent conjuctivitis is documented.
Results
She was refered to a gynaecologist due to infertility and cervicitis. Colposcopic and ultrasound examination of the uterus revealed, woody membraneous lesion which cover the inner site of the uterine cavity. We decided to give fresh frozen plasma (FFP) infusions both IV and locally to the uterine cavity after diagnosis of plasminogen deficiency. Heparine added FFP ( 50ml) also 5mg recombinant plazminogen activator ( rt-PA, ActilyseR)remained in the cavity for 2-4 hours. Although a regular cavity view was achieved after FFP replacement therapy and local application, freeze embrional transfer was performed without a proper pregnancy achievement.
Conclusion
Gynecologists and clinicians who are familiar with this bizarre disease’s clinical and histopathologic features will diagnose timely and manage properly.
Keyword(s): Fresh frozen plasma, Heparin, Plasminogen, TPA
Abstract: PB1832
Type: Publication Only
Session title: Thrombosis and vascular biology - Biology & Translational Research
Background
Plasminogen deficiency is a rare condition with autosomal recessive inheritance. Severe hypoplasminogenemia is associated with ‘ligneous’ lesions on each mucous membranes especialy eye, ear, mouth, pharynx, respiratory and female genital tract; cervix and endometrium. Furthermore, plasminogen deficient women complained from infertility. These kind of patient's diagnosis remained elusive for years.
Aims
We want to share this young women in order to take attention and form a greater familiarity with the clinical and histopathologic features of this condition among gynecologists.
Methods
Data from the files of a 32 year -old nulliparous young woman with intractable gingivitis and dental problems and a history of persistent conjuctivitis is documented.
Results
She was refered to a gynaecologist due to infertility and cervicitis. Colposcopic and ultrasound examination of the uterus revealed, woody membraneous lesion which cover the inner site of the uterine cavity. We decided to give fresh frozen plasma (FFP) infusions both IV and locally to the uterine cavity after diagnosis of plasminogen deficiency. Heparine added FFP ( 50ml) also 5mg recombinant plazminogen activator ( rt-PA, ActilyseR)remained in the cavity for 2-4 hours. Although a regular cavity view was achieved after FFP replacement therapy and local application, freeze embrional transfer was performed without a proper pregnancy achievement.
Conclusion
Gynecologists and clinicians who are familiar with this bizarre disease’s clinical and histopathologic features will diagnose timely and manage properly.
Keyword(s): Fresh frozen plasma, Heparin, Plasminogen, TPA