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CLINICO-HEMATOLOGICAL PREDICTORS OF RESPONSE DEEPENING AFTER STEM CELL TRANSPLANTATION IN PATIENTS WITH MULTIPLE MYELOMA
Author(s): ,
Ivan Kostroma
Affiliations:
Bone marrow transplantation,Russian Research Institute of Hematology and Transfusiology,S.Petersburg,Russian Federation
,
Anastasija Zhernjakova
Affiliations:
Bone marrow transplantation,Russian Research Institute of Hematology and Transfusiology,S.Petersburg,Russian Federation
,
Ruzilja Sabitova
Affiliations:
Bone marrow transplantation,Russian Research Institute of Hematology and Transfusiology,S.Petersburg,Russian Federation
,
Elena Stepchenkova
Affiliations:
Bone marrow transplantation,Russian Research Institute of Hematology and Transfusiology,S.Petersburg,Russian Federation
,
Stanislav Bessmel'tsev
Affiliations:
Bone marrow transplantation,Russian Research Institute of Hematology and Transfusiology,S.Petersburg,Russian Federation
Sergey Gritsaev
Affiliations:
Bone marrow transplantation,Russian Research Institute of Hematology and Transfusiology,S.Petersburg,Russian Federation
EHA Library. Kostroma I. 06/09/21; 324450; PB1779
Ivan Kostroma
Ivan Kostroma
Contributions
Abstract

Abstract: PB1779

Type: Publication Only

Session title: Stem cell transplantation - Clinical

Background
The effectiveness of multiple myeloma (MM) patients' treatment is dependent on the response to therapy including the stage of autologous stem cell transplantation (AutoSCT). The importance of predictors associated with the quality of response after AutoSCT is due to the possibility to change the option and intensity of condiioning regimen and/or posttransplantation consolidation.

Aims
To determine the frequency of MM cases without the improving of response after AutoSCT and evaluate the possibility to predict the effectivence of AutoSCT using clinical and hematological parameters. 

Methods
Retrospective analyses of 84 patients' data have been done. Total number of performed AutoSCT was 112 including 84 the first and 28 the second transplantation. The response was determined according to IMWG criteria. 

Results
Before the first AutoSCT the number of patients with complete (CR), very good partial (VGPR) and partial (PR) response were 31, 19 and 33 accordingly. One patient has MM stabilisation. Improving of the response depth after the first AutoSCT was recorded in 29/53 (54.7%) patients. Frequency of CR was higher in patients with previus VGPR than PR: 11/19 (57.9%) vs 6/33 (18.2%); p=0.005; OR=6.19, 95%CI 1.7-22. In the group without improving of response the number of patients received additional drugs to standard schemes with bortezomib and lenalidomide was higher than in the group with depeening of response: 29.2% vs 13.8%; difference not significant. The same situation was in relation to Mel200 conditioning regimen: 65.6% vs 79.3%.: difference not significant. The effectiveness of the second AutoSCT was evaluated in 2 patients with VGPR and 6 patients with PR. All patients with VGPR and 1 patient with PR had CR and 1 patient with PR reached VGPR. 4 patients with PR did not improve their response after the seconf AutoSCT. 

Conclusion
Reaching of CR after AutoSCT in patients with MM is dependent on the quality of previous response, scope of induction therapy and intensity of conditioning regimen. 

Keyword(s):

Abstract: PB1779

Type: Publication Only

Session title: Stem cell transplantation - Clinical

Background
The effectiveness of multiple myeloma (MM) patients' treatment is dependent on the response to therapy including the stage of autologous stem cell transplantation (AutoSCT). The importance of predictors associated with the quality of response after AutoSCT is due to the possibility to change the option and intensity of condiioning regimen and/or posttransplantation consolidation.

Aims
To determine the frequency of MM cases without the improving of response after AutoSCT and evaluate the possibility to predict the effectivence of AutoSCT using clinical and hematological parameters. 

Methods
Retrospective analyses of 84 patients' data have been done. Total number of performed AutoSCT was 112 including 84 the first and 28 the second transplantation. The response was determined according to IMWG criteria. 

Results
Before the first AutoSCT the number of patients with complete (CR), very good partial (VGPR) and partial (PR) response were 31, 19 and 33 accordingly. One patient has MM stabilisation. Improving of the response depth after the first AutoSCT was recorded in 29/53 (54.7%) patients. Frequency of CR was higher in patients with previus VGPR than PR: 11/19 (57.9%) vs 6/33 (18.2%); p=0.005; OR=6.19, 95%CI 1.7-22. In the group without improving of response the number of patients received additional drugs to standard schemes with bortezomib and lenalidomide was higher than in the group with depeening of response: 29.2% vs 13.8%; difference not significant. The same situation was in relation to Mel200 conditioning regimen: 65.6% vs 79.3%.: difference not significant. The effectiveness of the second AutoSCT was evaluated in 2 patients with VGPR and 6 patients with PR. All patients with VGPR and 1 patient with PR had CR and 1 patient with PR reached VGPR. 4 patients with PR did not improve their response after the seconf AutoSCT. 

Conclusion
Reaching of CR after AutoSCT in patients with MM is dependent on the quality of previous response, scope of induction therapy and intensity of conditioning regimen. 

Keyword(s):

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