Contributions
Abstract: PB1777
Type: Publication Only
Session title: Stem cell transplantation - Clinical
Background
Hematopoietic stem cell transplantation (HSCT) represents a cornerstone in individualized treatment algorithms in blood cancer. However, assessment of eligibility and outcome prediction remains challenging, particularly at advanced age.
Aims
This systematic review investigates the relevance of patient-orientated scores in decision-making in HSCT.
Methods
We performed a systematic review with a literature search on MEDLINE and Web of Science on the use and prognostic relevance of patient-centered scores in allogeneic and autologous HSCT in adult patients with hematologic malignancies.
Results
After screening 2326 studies, we identified 59 studies using at least one validated score to determine eligibility for HSCT, including 57 studies assessing performance status (PS) and three studies using comorbidity scores. Prognostic relevance of comorbidities was analysed in 128 studies, of PS in 67, of functional activities in three, of nutritional status in ten and of health-related quality of life (HRQOL) in six studies. Based on uni-/multivariate analyses, predictors of overall survival in allogeneic HSCT included comorbidities in 42/72 (58%) and in 39/58 (67%), PS in 20/33 (61%) and 30/37 (81%), nutritional status in 1/3 and 3/5, functional activities in 2/3 and 2/2 and HRQOL in 2/3 and 2/2, respectively. Likewise, comorbidities were predictors of reduced survival in autologous HSCT in 3/9 (33%) and 4/7 (57%) and PS in 4/5 (80%) and 4/6 (67%), respectively.
Conclusion
To date, validated patient-centered scores have been rarely used to evaluate eligibility for HSCT. The prognostic impact of comorbidities and of PS was demonstrated in a relevant proportion of studies and the results for the relevance of functional activities and HRQOL are encouraging. Thus, the relevance and further integration of patient-orientated scoring in decision-making in HSCT is underlined.
Keyword(s): Bone marrow transplant, Comorbidities, Elderly, Prognosis
Abstract: PB1777
Type: Publication Only
Session title: Stem cell transplantation - Clinical
Background
Hematopoietic stem cell transplantation (HSCT) represents a cornerstone in individualized treatment algorithms in blood cancer. However, assessment of eligibility and outcome prediction remains challenging, particularly at advanced age.
Aims
This systematic review investigates the relevance of patient-orientated scores in decision-making in HSCT.
Methods
We performed a systematic review with a literature search on MEDLINE and Web of Science on the use and prognostic relevance of patient-centered scores in allogeneic and autologous HSCT in adult patients with hematologic malignancies.
Results
After screening 2326 studies, we identified 59 studies using at least one validated score to determine eligibility for HSCT, including 57 studies assessing performance status (PS) and three studies using comorbidity scores. Prognostic relevance of comorbidities was analysed in 128 studies, of PS in 67, of functional activities in three, of nutritional status in ten and of health-related quality of life (HRQOL) in six studies. Based on uni-/multivariate analyses, predictors of overall survival in allogeneic HSCT included comorbidities in 42/72 (58%) and in 39/58 (67%), PS in 20/33 (61%) and 30/37 (81%), nutritional status in 1/3 and 3/5, functional activities in 2/3 and 2/2 and HRQOL in 2/3 and 2/2, respectively. Likewise, comorbidities were predictors of reduced survival in autologous HSCT in 3/9 (33%) and 4/7 (57%) and PS in 4/5 (80%) and 4/6 (67%), respectively.
Conclusion
To date, validated patient-centered scores have been rarely used to evaluate eligibility for HSCT. The prognostic impact of comorbidities and of PS was demonstrated in a relevant proportion of studies and the results for the relevance of functional activities and HRQOL are encouraging. Thus, the relevance and further integration of patient-orientated scoring in decision-making in HSCT is underlined.
Keyword(s): Bone marrow transplant, Comorbidities, Elderly, Prognosis