Contributions
Abstract: PB1600
Type: Publication Only
Session title: Infections in hematology (incl. supportive care/therapy)
Background
Chemotherapy induced myelosuppression is one of the major dose-limiting toxicities of systemic chemotherapy. It results to dose reductions and treatment delays hence compromising treatment-efficacy and long-term clinical outcomes. Moreover, the burden of these complications to patients as well to their caregivers could be economically troublesome and would require substantial resource allocation.
Aims
This study determined the infection profile and outcomes of adult acute leukemia patients developing chemotherapy-associated febrile neutropenia and identified the antimicrobial sensitivity patterns of the bacterial blood isolates.
Methods
This was a single-center retrospective study which reviewed medical records of 100 adult acute leukemia patients who developed chemotherapy-associated febrile neutropenia. Descriptive statistics was used to summarize demographic and clinical characteristics. Independent Sample T-test, Mann-Whitney U-test and Fisher’s Exact/Chi-square test determined difference of mean, rank and frequency between AML and ALL. STATA 13.1 was used for data analysis.
Results
There were 106 microbiological isolates. Most commonly isolated were Escherichia coli (ESBL-48.39%), Klebsiella pneumoniae (ESBL-61.90%) and coagulase-negative Staphylococcus (CoNS). Organisms were isolated from blood (57.55%), sputum (15.09%), urine (12.26%), and stool (7.55%). More ALL patients had Klebsiella pneumoniae isolates (p-value: <0.001). Presence of Carbapenemase-producing Klebsiella was statistically significant in the mortality group (p-value: 0.018). Susceptibility patterns show: (1) E. colisusceptible to Carbapenems, Cefepime and Aminoglycosides (2) K. pneumoniae to Carbapenems and Aminoglycosides (3) CoNS to Vancomycin.
Conclusion
This study emphasized the need to identify the most commonly isolated pathogens to aid physicians decide on the appropriate empiric antibiotic/s to use during chemotherapy-associated febrile neutropenia to avoid serious morbidity and mortality. Proper coordination between clinician and microbiological laboratory for prompt pathogen identification and monitoring of microbial susceptibility patterns is vital to provide the best treatment option for this patient population.
Keyword(s): Acute leukemia, Chemotherapy, Febrile neutropenia
Abstract: PB1600
Type: Publication Only
Session title: Infections in hematology (incl. supportive care/therapy)
Background
Chemotherapy induced myelosuppression is one of the major dose-limiting toxicities of systemic chemotherapy. It results to dose reductions and treatment delays hence compromising treatment-efficacy and long-term clinical outcomes. Moreover, the burden of these complications to patients as well to their caregivers could be economically troublesome and would require substantial resource allocation.
Aims
This study determined the infection profile and outcomes of adult acute leukemia patients developing chemotherapy-associated febrile neutropenia and identified the antimicrobial sensitivity patterns of the bacterial blood isolates.
Methods
This was a single-center retrospective study which reviewed medical records of 100 adult acute leukemia patients who developed chemotherapy-associated febrile neutropenia. Descriptive statistics was used to summarize demographic and clinical characteristics. Independent Sample T-test, Mann-Whitney U-test and Fisher’s Exact/Chi-square test determined difference of mean, rank and frequency between AML and ALL. STATA 13.1 was used for data analysis.
Results
There were 106 microbiological isolates. Most commonly isolated were Escherichia coli (ESBL-48.39%), Klebsiella pneumoniae (ESBL-61.90%) and coagulase-negative Staphylococcus (CoNS). Organisms were isolated from blood (57.55%), sputum (15.09%), urine (12.26%), and stool (7.55%). More ALL patients had Klebsiella pneumoniae isolates (p-value: <0.001). Presence of Carbapenemase-producing Klebsiella was statistically significant in the mortality group (p-value: 0.018). Susceptibility patterns show: (1) E. colisusceptible to Carbapenems, Cefepime and Aminoglycosides (2) K. pneumoniae to Carbapenems and Aminoglycosides (3) CoNS to Vancomycin.
Conclusion
This study emphasized the need to identify the most commonly isolated pathogens to aid physicians decide on the appropriate empiric antibiotic/s to use during chemotherapy-associated febrile neutropenia to avoid serious morbidity and mortality. Proper coordination between clinician and microbiological laboratory for prompt pathogen identification and monitoring of microbial susceptibility patterns is vital to provide the best treatment option for this patient population.
Keyword(s): Acute leukemia, Chemotherapy, Febrile neutropenia