Contributions
Abstract: PB1591
Type: Publication Only
Session title: Infections in hematology (incl. supportive care/therapy)
Background
Late-onset severe pneumonia (LOSP) is defined as severe pneumonia developed during the late phase of allogeneic hematopoietic stem cell transplantation (allo-HSCT). Patients with LOSP have high mortality, so it is important to identify prognostic factors.
Aims
In this study, we aimed to develop a risk score system with broad applicability that could help predict the risk of LOSP-associated mortality.
Methods
We retrospectively analyzed 100 patients with LOSP after allo-HSCT from June 2009 to July 2017. The assessment variables included immune, nutritional and metabolic parameters at the onset of LOSP.
Results
Of all 100 patients who suffered LOSP after allo-HSCT, 45 (45.0%) patients eventually died, and 55 (55.0%) patients were positive for pathogens, with the most common being viruses. In the multivariate analysis, higher monocyte (≥0.20 vs. <0.20×109/L, P=0.001), higher albumin (≥30.5 vs. <30.5 g/L, P=0.044), lower LDH (<250 vs. ≥250 U/L, P=0.008) and lower BUN (<7.2 vs. ≥7.2 mmol/L, P=0.026) levels at the onset of LOSP were significantly associated with better 60-day survival. A risk score system based on the above results showed that the probability of 60-day survival decreased with increasing risk factors and were 96.3% (low-risk group), 49.1% (intermediate-risk group) and 12.5% (high-risk group).
Conclusion
The results indicated that the scoring system including several variables could stratify patients with different probabilities of survival after LOSP, which is of great clinical significance.
Keyword(s): Infection, Stem cell transplant
Abstract: PB1591
Type: Publication Only
Session title: Infections in hematology (incl. supportive care/therapy)
Background
Late-onset severe pneumonia (LOSP) is defined as severe pneumonia developed during the late phase of allogeneic hematopoietic stem cell transplantation (allo-HSCT). Patients with LOSP have high mortality, so it is important to identify prognostic factors.
Aims
In this study, we aimed to develop a risk score system with broad applicability that could help predict the risk of LOSP-associated mortality.
Methods
We retrospectively analyzed 100 patients with LOSP after allo-HSCT from June 2009 to July 2017. The assessment variables included immune, nutritional and metabolic parameters at the onset of LOSP.
Results
Of all 100 patients who suffered LOSP after allo-HSCT, 45 (45.0%) patients eventually died, and 55 (55.0%) patients were positive for pathogens, with the most common being viruses. In the multivariate analysis, higher monocyte (≥0.20 vs. <0.20×109/L, P=0.001), higher albumin (≥30.5 vs. <30.5 g/L, P=0.044), lower LDH (<250 vs. ≥250 U/L, P=0.008) and lower BUN (<7.2 vs. ≥7.2 mmol/L, P=0.026) levels at the onset of LOSP were significantly associated with better 60-day survival. A risk score system based on the above results showed that the probability of 60-day survival decreased with increasing risk factors and were 96.3% (low-risk group), 49.1% (intermediate-risk group) and 12.5% (high-risk group).
Conclusion
The results indicated that the scoring system including several variables could stratify patients with different probabilities of survival after LOSP, which is of great clinical significance.
Keyword(s): Infection, Stem cell transplant