Contributions
Abstract: PB1586
Type: Publication Only
Session title: Infections in hematology (incl. supportive care/therapy)
Background
Bacteraemia adversely affect the outcome of pediatric patients with hematologic malignancies.
Aims
This study aimed to describe the epidemiology, outcome, and factor influencing mortality of bacteremia in children with hematologic malignancies.
Methods
This is a descriptive retrospective study. Data belonging to bacteraemia in pediatric (<16 years) patients with hematologic malignancies admitted in our department of hematology during the period spanning from January 2010 and November 2019 were analyzed. Risk factors with a P-value less than 0.20 were initially included in the binary logistic regression model to determine the independent risk factors for mortality Bloodstream infection in adult hematologic malignancies. Factors described in previous literature were also included in the model. Then the model was reduced by means of manual backward elimination. P values ≤ 0.05 were considered statistically significant.
Results
One hundred thirty nine bacteremia episodes among 110 patients were identified. Underlying diseases were acute lymphoblastic leukemia (ALL) 106(76.3%) which far exceeds acute myeloid leukemia (AML) 29 (20.9%). The bacteraemia occurred in 68 patients with uncontrolled/ relapse or refractory disease. The majority of BSI episodes occurred in the presence of severe neutropenia (62.6%). Ninety-four (67.6%) of the culture isolates were Gram-negative bacteria and 45 (32.4%) were Gram-positive bacteria. Klebsiella species and Escherichia coli were the most common Gram-negative isolates. Staphylococcus aureus and staphylococcus epidermidis were the most common Gram-positive isolates. A multidrug-resistant bacteria was present in 31 (22.3%) cases. In 96 (69.1%) episodes, patients received an appropriate antibiotherapy. Complications occurred in 24 (17.3%) episodes of bacteremia. seven children died during bacteremia, giving a case-fatality rate of 5%. The independent risk Factor influencing mortality were : qSOFA>2 (P: 0.002).
Conclusion
Bacteremia in these patients was caused mainly by Gram-negative microorganisms and was associated with a low case-fatality rate. Factor influencing mortality was qSOFA>2.
Keyword(s): Hematological malignancy, Infection, Pediatric
Abstract: PB1586
Type: Publication Only
Session title: Infections in hematology (incl. supportive care/therapy)
Background
Bacteraemia adversely affect the outcome of pediatric patients with hematologic malignancies.
Aims
This study aimed to describe the epidemiology, outcome, and factor influencing mortality of bacteremia in children with hematologic malignancies.
Methods
This is a descriptive retrospective study. Data belonging to bacteraemia in pediatric (<16 years) patients with hematologic malignancies admitted in our department of hematology during the period spanning from January 2010 and November 2019 were analyzed. Risk factors with a P-value less than 0.20 were initially included in the binary logistic regression model to determine the independent risk factors for mortality Bloodstream infection in adult hematologic malignancies. Factors described in previous literature were also included in the model. Then the model was reduced by means of manual backward elimination. P values ≤ 0.05 were considered statistically significant.
Results
One hundred thirty nine bacteremia episodes among 110 patients were identified. Underlying diseases were acute lymphoblastic leukemia (ALL) 106(76.3%) which far exceeds acute myeloid leukemia (AML) 29 (20.9%). The bacteraemia occurred in 68 patients with uncontrolled/ relapse or refractory disease. The majority of BSI episodes occurred in the presence of severe neutropenia (62.6%). Ninety-four (67.6%) of the culture isolates were Gram-negative bacteria and 45 (32.4%) were Gram-positive bacteria. Klebsiella species and Escherichia coli were the most common Gram-negative isolates. Staphylococcus aureus and staphylococcus epidermidis were the most common Gram-positive isolates. A multidrug-resistant bacteria was present in 31 (22.3%) cases. In 96 (69.1%) episodes, patients received an appropriate antibiotherapy. Complications occurred in 24 (17.3%) episodes of bacteremia. seven children died during bacteremia, giving a case-fatality rate of 5%. The independent risk Factor influencing mortality were : qSOFA>2 (P: 0.002).
Conclusion
Bacteremia in these patients was caused mainly by Gram-negative microorganisms and was associated with a low case-fatality rate. Factor influencing mortality was qSOFA>2.
Keyword(s): Hematological malignancy, Infection, Pediatric