Contributions
Abstract: PB1558
Type: Publication Only
Session title: Hodgkin lymphoma - Clinical
Background
The standard treatment for adolescent patients with Hodgkin lymphoma (HL) is not well defined, especially in the choice between pediatric and adult protocols.
Aims
To compare the risk factors and the therapeutic results of adolescents and young adults with HL treated with ABVD.
Methods
98 patients treated in our department between 2000 and 2015 were analyzed: 33 adolescents aged between 15 and 21 years, and 65 young adults aged between 22 and 39 years. All patients received the ABVD protocol as initial chemotherapy, followed in 65 (66.3%) by radiotherapy. We compared the characteristics of patients of the two populations using Fisher's exact test. Survival was estimated using the Kaplan and Meier method, and compared by the log rank test. A Cox proportional hazards model regression was used to assess prognostic factors in adolescent patients.
Results
Histologic type 2 as well as hypoalbuminaemia were more common in adolescent patients (P = 0.05, P = 0.02 respectively). The incidence of other risk factors is not significantly different between the two populations. With a median follow-up of 67 months, overall survival (OS) and 5-year event-free survival (EFS) rates are of 79% and 72% for all the patients. The overall complete remission rate (CR) is 87.8%, 84.8% for adolescents and 89% for young adults (P = 0.53). The log rank test showed no significant difference between the two age groups in OS (P = 0.31) or EFS (P = 0.51). At 5 years, the estimate of OS and EFS are of 77% and 74% for young adults, 73% and 68% for adolescents, respectively. After Cox model analysis, two factors were important for the prognosis of adolescent patients: massive tumor involvement (P = 0.008) and extranodal involvement (P = 0.04).
Conclusion
The prognosis and risk factors of adolescent and young adult patients with HL, treated with ABVD are comparable. These data suggest that adult treatment protocols are safe and an effective option for adolescent patients.
Keyword(s): Adolescents, Hodgkin's lymphoma, Remission, Survival
Abstract: PB1558
Type: Publication Only
Session title: Hodgkin lymphoma - Clinical
Background
The standard treatment for adolescent patients with Hodgkin lymphoma (HL) is not well defined, especially in the choice between pediatric and adult protocols.
Aims
To compare the risk factors and the therapeutic results of adolescents and young adults with HL treated with ABVD.
Methods
98 patients treated in our department between 2000 and 2015 were analyzed: 33 adolescents aged between 15 and 21 years, and 65 young adults aged between 22 and 39 years. All patients received the ABVD protocol as initial chemotherapy, followed in 65 (66.3%) by radiotherapy. We compared the characteristics of patients of the two populations using Fisher's exact test. Survival was estimated using the Kaplan and Meier method, and compared by the log rank test. A Cox proportional hazards model regression was used to assess prognostic factors in adolescent patients.
Results
Histologic type 2 as well as hypoalbuminaemia were more common in adolescent patients (P = 0.05, P = 0.02 respectively). The incidence of other risk factors is not significantly different between the two populations. With a median follow-up of 67 months, overall survival (OS) and 5-year event-free survival (EFS) rates are of 79% and 72% for all the patients. The overall complete remission rate (CR) is 87.8%, 84.8% for adolescents and 89% for young adults (P = 0.53). The log rank test showed no significant difference between the two age groups in OS (P = 0.31) or EFS (P = 0.51). At 5 years, the estimate of OS and EFS are of 77% and 74% for young adults, 73% and 68% for adolescents, respectively. After Cox model analysis, two factors were important for the prognosis of adolescent patients: massive tumor involvement (P = 0.008) and extranodal involvement (P = 0.04).
Conclusion
The prognosis and risk factors of adolescent and young adult patients with HL, treated with ABVD are comparable. These data suggest that adult treatment protocols are safe and an effective option for adolescent patients.
Keyword(s): Adolescents, Hodgkin's lymphoma, Remission, Survival