Contributions
Abstract: PB1489
Type: Publication Only
Session title: Bone marrow failure syndromes incl. PNH - Clinical
Background
In bone marrow metastasis, the search of primary tumor is important as prompt treatment dictates prognosis of patient. However, site of primary tumor remains elusive in 10-30% of metastatic cancer despite extensive search.
Aims
At Clinical Referral Haematology Laboratory, Hospital Ampang, which is the tertiary referral laboratory for all hospitals within the Ministry of Health in Malaysia, we performed a retrospective review on the cases with a trephine diagnosis of metastatic carcinoma between 2010-2020.
Methods
A bone marrow trephine biopsy was performed based on patients' clinical presentation and cytopenia from full blood count. We analyzed each report individually and extracted the patients’ clinical data from our cases and report, including the primary tumor and or possible metastasis site as well as survival rates.
Results
There were 14 cases of tumors metastatic to the bone marrow comprising of 9 women and 5 men, with median age of 60.3-year-old. Metastasis was made upon a bone marrow trephine biopsy was performed. Preliminary of 6 cases who we manage to identify the site of primary tumor whereas the rest of the cases with unknown primary bone marrow metastasis.
Conclusion
Bone marrow metastasis is an infrequent event. Close collaboration between clinician and pathologist is essential for diagnosis, identification of tumour subtype and even primary site of tumour for management and prognostication for cancer of unknown primary. Outcome of unfavourable cancer of unknown primary is poor even with recommended treatment.
Keyword(s): Bone marrow involvement, Metastasis
Abstract: PB1489
Type: Publication Only
Session title: Bone marrow failure syndromes incl. PNH - Clinical
Background
In bone marrow metastasis, the search of primary tumor is important as prompt treatment dictates prognosis of patient. However, site of primary tumor remains elusive in 10-30% of metastatic cancer despite extensive search.
Aims
At Clinical Referral Haematology Laboratory, Hospital Ampang, which is the tertiary referral laboratory for all hospitals within the Ministry of Health in Malaysia, we performed a retrospective review on the cases with a trephine diagnosis of metastatic carcinoma between 2010-2020.
Methods
A bone marrow trephine biopsy was performed based on patients' clinical presentation and cytopenia from full blood count. We analyzed each report individually and extracted the patients’ clinical data from our cases and report, including the primary tumor and or possible metastasis site as well as survival rates.
Results
There were 14 cases of tumors metastatic to the bone marrow comprising of 9 women and 5 men, with median age of 60.3-year-old. Metastasis was made upon a bone marrow trephine biopsy was performed. Preliminary of 6 cases who we manage to identify the site of primary tumor whereas the rest of the cases with unknown primary bone marrow metastasis.
Conclusion
Bone marrow metastasis is an infrequent event. Close collaboration between clinician and pathologist is essential for diagnosis, identification of tumour subtype and even primary site of tumour for management and prognostication for cancer of unknown primary. Outcome of unfavourable cancer of unknown primary is poor even with recommended treatment.
Keyword(s): Bone marrow involvement, Metastasis