Contributions
Abstract: PB1427
Type: Publication Only
Session title: Acute myeloid leukemia - Clinical
Background
Many cases of simultaneous development of inflammatory bowl diseases and myelodysplastic syndrome or acute myeloid leukemia have been reported since 1980. Until today there are 70 cases including ours published in reference sites in the majority of these cases the acute leukemia was associated with the ulcerative colitis while the Crohn’s disease was associated with the myelodysplastic syndrome (MDS).
Aims
The objective is to insist on the association between inflammatory bowel disease and myelodysplasia or acute leukemia and to analyze the propses explanations for the mechanism leading to this association
Methods
We report two cases ,followed up in our clinical hematology service in Monastir-TUNISIA,of crohn’s disease associated with hematological malignancies: the first is about a patient who had myelodysplasia progressed to an acute myeloid leukemia (AML) in whom Crohn’s disease was diagnosed few months later. The second is a about a simultaneous discovery of crohn’s disease and acute myeloid Leukemia: this patient was followed up by gastrologists for crohn’s disease and some months later (before the onset of the treatment) a myeloid leukemia was diagnosed.
Results
Many studies reported patients with myelodysplastic syndrome or myeloid leukemia associated with Crohn’s disease have received treatment for crohn’s disease or radiological examinations before the onset of the hematologic malignancy . However other studies have found that there’s no connection between radiation, Crohn’s disease treatment and the onset of MDS or leukemia. Our cases confirmed these studies because the MDS or the AML were discovered before the onset of the Crohn’s disease treatment.
The other propositions include a common chromosome abnormality. However, many cases have been reported to have normal karyotype. In our cases the karyotype was abnormal witch can support this suggestion but the fact that many cases present a normal karyotype still against.
The most attractive proposition still: a common immune dysfunction: admitting that inflammatory bowel disease and MDS are autoimmune diseases. In the MDS there is T-cell clonal proliferation, tumor necrosis factor secretion and excessive interleukin 1 and 6 which can lead to the development of the IBD.
Conclusion
Crohn’s disease can precede the MDS or acute leukemia or inversely, so a patient followed up by hematologists for a hematological malignancy can develop an inflammatory bowel disease and a patient followed up by gastrologists for IBD can develop a MDS or AML.
Many explanations were supposed to the possible common mechanism leading to this association but the causal relationship has yet to be determined.
Keyword(s): Acute myeloid leukemia, Myelodysplasia
Abstract: PB1427
Type: Publication Only
Session title: Acute myeloid leukemia - Clinical
Background
Many cases of simultaneous development of inflammatory bowl diseases and myelodysplastic syndrome or acute myeloid leukemia have been reported since 1980. Until today there are 70 cases including ours published in reference sites in the majority of these cases the acute leukemia was associated with the ulcerative colitis while the Crohn’s disease was associated with the myelodysplastic syndrome (MDS).
Aims
The objective is to insist on the association between inflammatory bowel disease and myelodysplasia or acute leukemia and to analyze the propses explanations for the mechanism leading to this association
Methods
We report two cases ,followed up in our clinical hematology service in Monastir-TUNISIA,of crohn’s disease associated with hematological malignancies: the first is about a patient who had myelodysplasia progressed to an acute myeloid leukemia (AML) in whom Crohn’s disease was diagnosed few months later. The second is a about a simultaneous discovery of crohn’s disease and acute myeloid Leukemia: this patient was followed up by gastrologists for crohn’s disease and some months later (before the onset of the treatment) a myeloid leukemia was diagnosed.
Results
Many studies reported patients with myelodysplastic syndrome or myeloid leukemia associated with Crohn’s disease have received treatment for crohn’s disease or radiological examinations before the onset of the hematologic malignancy . However other studies have found that there’s no connection between radiation, Crohn’s disease treatment and the onset of MDS or leukemia. Our cases confirmed these studies because the MDS or the AML were discovered before the onset of the Crohn’s disease treatment.
The other propositions include a common chromosome abnormality. However, many cases have been reported to have normal karyotype. In our cases the karyotype was abnormal witch can support this suggestion but the fact that many cases present a normal karyotype still against.
The most attractive proposition still: a common immune dysfunction: admitting that inflammatory bowel disease and MDS are autoimmune diseases. In the MDS there is T-cell clonal proliferation, tumor necrosis factor secretion and excessive interleukin 1 and 6 which can lead to the development of the IBD.
Conclusion
Crohn’s disease can precede the MDS or acute leukemia or inversely, so a patient followed up by hematologists for a hematological malignancy can develop an inflammatory bowel disease and a patient followed up by gastrologists for IBD can develop a MDS or AML.
Many explanations were supposed to the possible common mechanism leading to this association but the causal relationship has yet to be determined.
Keyword(s): Acute myeloid leukemia, Myelodysplasia