Contributions
Abstract: PB1362
Type: Publication Only
Session title: Acute lymphoblastic leukemia - Clinical
Background
Cancer is a public health problem that affects the whole world, is divided into 2 major groups, solid tumors and hematological malignancies (HM). International studies mainly from developed countries report that HM account for 10% of all cancers, being the most frequent lymphoma followed by multiple myeloma (MM). National Cancer Institute (NCI), the leading public institution in Peru treats almost the 20% of cancer patients in the country.
Aims
To determine the incidence of HM by sub-type in the leading cancer center in Peru and its association with sex and age group.
Methods
We reviewed the database at the NCI Epidemiology Department in Peru from 2000 to 2018. The classification was based on the International Classification version 10 (ICD-10) and the ICD for Oncology version 3 (ICD-O 3) and divided into the main subtypes: Acute Lymphoblastic Leukemia (ALL), Acute Myeloid Leukemia (AML), Chronic Lymphocytic Leukemia (CLL), Chronic Myeloid Leukemia (CML), Non-Hodgkin lymphoma (NHL), Hodgkin lymphoma (HL), MM, other leukemias (OtL), and other HM (oHM). Baseline characteristics (BLC) as age, age group, sex and sub-type of HM were collected. The age group was divided as follows: 0-14 years, 15-39 years (Adolescent and Young Adult, AYA), 40-64 years, and >64 years. BLC were compared using Chi-square test. The Stata software version 16 was use for the analysis.
Results
During the study period 12.4% (n= 23,795) were HM. The median age was 43 (range 0-103). 53.7% (n=12,798) were male. The most frequent HM was NHL with 44.1% (n=10,502), followed by ALL with 23.9% (n=5,684) and AML with 12.9% (n=3,072). MM and HL were 5.7% and 5.5% (n=1,351, and n=1,316), respectively. CLL was presented in 0.95% (n=225). The most frequent age group was those 40-64 years old with 32.1% (n=7,642), follow by the AYA group with 24.4% (n=5,812), the less common groups were 0-14 years group with 21.5% (n=5,113) and >64 years with 21.97% (n=5228). In the 0-14 group the most frequent HM was ALL with 63.1% (n=3,226) followed by AML with 13.5% (n=689). In the AYA group the most frequent HM was NHL with 31.5% (n=1,833) followed by ALL with 29.7% (n=1,727). In the 40-64 group the most frequent HM was NHL with 58.5% (n=4,497) followed by AML with 11.6% (n=889) and in the > 64 years group was NHL with 69.5% (n=3,632) followed by MM with 9.8% (n=514). There was a statistically significant difference between the subtypes and age ranges (p<0.001) (see table 1). In the first three age groups the most frequent sex was male, with 58.9%, 56.7% and 51%, respectively. However, in the > 64 years group the predominant sex was female with 50.6%. The difference between sex and age ranges was statistically significant p<0.001.
Conclusion
HM account for 12% of cancers. Most of patients are male. The most affected group was 40-64 years. The most frequent HM is NHL. Unlike developed countries the second most frequent HM was ALL, being this latter the most frequent HM in the 0-14 years group and the most frequent leukemia in AYA group. AML was the second most frequent HM in 0-14 years group and the most frequent leukemia in ≥ 40 years group. Also, unlike developed countries CLL was rare. MM ranked fifth in incidence. There was a statistically significant difference between the subtype and the age range.
Keyword(s): Adult, Hematological malignancy, Incidence, Pediatric
Abstract: PB1362
Type: Publication Only
Session title: Acute lymphoblastic leukemia - Clinical
Background
Cancer is a public health problem that affects the whole world, is divided into 2 major groups, solid tumors and hematological malignancies (HM). International studies mainly from developed countries report that HM account for 10% of all cancers, being the most frequent lymphoma followed by multiple myeloma (MM). National Cancer Institute (NCI), the leading public institution in Peru treats almost the 20% of cancer patients in the country.
Aims
To determine the incidence of HM by sub-type in the leading cancer center in Peru and its association with sex and age group.
Methods
We reviewed the database at the NCI Epidemiology Department in Peru from 2000 to 2018. The classification was based on the International Classification version 10 (ICD-10) and the ICD for Oncology version 3 (ICD-O 3) and divided into the main subtypes: Acute Lymphoblastic Leukemia (ALL), Acute Myeloid Leukemia (AML), Chronic Lymphocytic Leukemia (CLL), Chronic Myeloid Leukemia (CML), Non-Hodgkin lymphoma (NHL), Hodgkin lymphoma (HL), MM, other leukemias (OtL), and other HM (oHM). Baseline characteristics (BLC) as age, age group, sex and sub-type of HM were collected. The age group was divided as follows: 0-14 years, 15-39 years (Adolescent and Young Adult, AYA), 40-64 years, and >64 years. BLC were compared using Chi-square test. The Stata software version 16 was use for the analysis.
Results
During the study period 12.4% (n= 23,795) were HM. The median age was 43 (range 0-103). 53.7% (n=12,798) were male. The most frequent HM was NHL with 44.1% (n=10,502), followed by ALL with 23.9% (n=5,684) and AML with 12.9% (n=3,072). MM and HL were 5.7% and 5.5% (n=1,351, and n=1,316), respectively. CLL was presented in 0.95% (n=225). The most frequent age group was those 40-64 years old with 32.1% (n=7,642), follow by the AYA group with 24.4% (n=5,812), the less common groups were 0-14 years group with 21.5% (n=5,113) and >64 years with 21.97% (n=5228). In the 0-14 group the most frequent HM was ALL with 63.1% (n=3,226) followed by AML with 13.5% (n=689). In the AYA group the most frequent HM was NHL with 31.5% (n=1,833) followed by ALL with 29.7% (n=1,727). In the 40-64 group the most frequent HM was NHL with 58.5% (n=4,497) followed by AML with 11.6% (n=889) and in the > 64 years group was NHL with 69.5% (n=3,632) followed by MM with 9.8% (n=514). There was a statistically significant difference between the subtypes and age ranges (p<0.001) (see table 1). In the first three age groups the most frequent sex was male, with 58.9%, 56.7% and 51%, respectively. However, in the > 64 years group the predominant sex was female with 50.6%. The difference between sex and age ranges was statistically significant p<0.001.
Conclusion
HM account for 12% of cancers. Most of patients are male. The most affected group was 40-64 years. The most frequent HM is NHL. Unlike developed countries the second most frequent HM was ALL, being this latter the most frequent HM in the 0-14 years group and the most frequent leukemia in AYA group. AML was the second most frequent HM in 0-14 years group and the most frequent leukemia in ≥ 40 years group. Also, unlike developed countries CLL was rare. MM ranked fifth in incidence. There was a statistically significant difference between the subtype and the age range.
Keyword(s): Adult, Hematological malignancy, Incidence, Pediatric