Mechanisms, mishaps and manipulation of iron uptake
Cavan Bennett
Walter and Eliza Hall Institute of Medical Research, Parkville, Australia / Department of Medical Biology, The
University of Melbourne, Parkville, Australia
EHA Library. Pasricha S. 06/15/19; 273689
Sant-Ryan Pasricha
Sant-Ryan Pasricha
Learning Objectives

Martina U. Muckenthaler - Chair introduction

Systemic iron homeostasis is maintained by the iron-regulated peptide hormone hepcidin and its target receptor, the iron exporter ferroportin. The hepcidin/ferroportin regulatory axis prevents diseases of iron overload (ie, Hereditary hemochromatosis, thalassemia) or iron deficiency (ie, anemia). In this session, we will discuss pathologies underlying these frequent disorders and dissect mechanisms that cause functional or absolute iron overload or deficiency. We will explore novel approaches to oral iron treatment, the value of hepcidin as a diagnostic marker and how novel therapeutics just entering clinical trials modulate plasma iron availability via the hepcidin/ferroportin regulatory system. This session provides an exciting example for how knowledge derived from basic research can be translated into the clinic.

Learning goals of the article
The aim of this educational session is to generate novel insight into.
• frequent pathologies caused by a misregulation of the hepcidin/ferroportin system.
• novel approaches to oral iron treatment.
• diagnosis of iron-related disorders.

Learning goals of the presentation
After attending this lecture, the participant will be able to
• understand the basic physiology governing iron absorption and utilisation,
• appreciate the gastrointestinal and systemic conditions that may impair intestinal iron absorption, and
• discuss emerging options for treatment of iron disorders that manipulate the hepcidin-ferroportin axis.

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