CLINICAL RESPONSES AND PHARMACOKINETICS OF FULLY HUMAN BCMA TARGETING CAR T CELL THERAPY IN RELAPSED/REFRACTORY MULTIPLE MYELOMA
Author(s): ,
Chunrui Li
Affiliations:
Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology,Wuhan,China
,
jianfeng zhou
Affiliations:
Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology,Wuhan,China
,
jue wang
Affiliations:
Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology,Wuhan,China
,
guang hu
Affiliations:
Nanjing Iaso Biotherapeutics Co.,Ltd,Nanjing,China
,
aihua du
Affiliations:
Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology,Wuhan,China
,
xiaoxi zhou
Affiliations:
Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology,Wuhan,China
,
zhenye hong
Affiliations:
Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology,Wuhan,China
,
li meng
Affiliations:
Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology,Wuhan,China
,
liting chen
Affiliations:
Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology,Wuhan,China
xia mao
Affiliations:
Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology,Wuhan,China
EHA Library. li C. Jun 15, 2019; 267410; S827
Chunrui li
Chunrui li
Contributions
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Abstract

Abstract: S827

Type: Oral Presentation

Presentation during EHA24: On Saturday, June 15, 2019 from 12:30 - 12:45

Location: Auditorium

Background
Previous studies indicate patients with relapsed/refractory multiple myeloma (RRMM) who receive high-dose BCMA-targeting CAR-T cells may achieve better remission but have worse adverse events. Moreover, once the disease progresses again, the re-infusion of CAR-T cells is not effective. To solve this dilemma, we have developed a novel BCMA-targeting CAR-T (CT103A) with a lentiviral vector containing a CAR structure with a fully human scFv, CD8a hinger and transmembrane, 4-1BB co-stimulatory and CD3z activation domains.

Aims
The primary objectives are to characterize the safety and tolerability in patients with R/R MM. The secondary objectives include evaluation of anti-myeloma activity, cytokines, CAR-T cell persistence, and pharmacokinetics. 

Methods
ChiCTR1800018137 is a single-center and single-arm trial of CT103A in patients with RRMM. Between September 21, 2018, and January 21, 2019, nine patients (including 3 patients having relapsed after being given a murine BCMA CAR-T) received CT103A in 3+3 dose-escalation trial (three doses at 1, 3, 6 ×106/kg) after a conditioning chemotherapy regimen of cyclophosphamide and fludarabine. All Patients had received a median of 4 prior lines (range 3 - 5) of MM therapy. 

Results
At the time of the February 4, 2019 data analysis, the overall response rate was 100% (Table1), and all patients had a rapid response within 14 days, with 67% (2/3) reaching CR/sCR at the lowest dose. The pharmacokinetics of CT103A were assessed by a digital polymerase chain reaction. Robust expansions were seen even at the lowest dosage level. In addition, Cmax and AUC0-28 reached levels comparable to reported CD19 CAR-T. In the first two dose groups, the grade of cytokine release syndrome (CRS) was 0 - 2. In the 6 ×106 /kg dose group, DLT had been observed in one patient.

Table 1. Treatment Response (Case 1,5 and 7 are murine BCMA CAR-T relapse patients)

Case

CAR T-Cell Dose (×106/kg)

D14

D30

D60

D90

D120

1

1

CR

CR

CR

CR

CR

2

1

SD

MR

PR

PR

PR

3

1

CR

CR

CR

CR

 

4

3

MR

PR

PR

   

5

3

CR

CR

CR

   

6

3

CR

CR

     

7

6

PR

VGPR

     

8

6

PR

       

9

6

PR

       

 

 

Conclusion

Data from this early-stage clinical study showed the unparalleled safety and efficacy of CT103A. Major AEs were transient, manageable, and reversible. three patients who relapsed the murine BCMA CAR-T were treated with CT103A, two patients achieved CR, and one patient achieved VGPR. 100% ORR and a rapid response within 2 weeks, suggests CT103A could be developed as a competitive therapeutic to treat patients with RRMM.

 

Session topic: 14. Myeloma and other monoclonal gammopathies - Clinical

Keyword(s): Cancer immunotherapy, Myeloma, Treatment

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