FIBRINOLYSIS IN PATIENTS WITH CHEMOTHERAPY INDUCED THROMBOCYTOPENIA AND THE EFFECT OF PLATELET TRANSFUSION.
Author(s): ,
Floor Heubel-Moenen
Affiliations:
Hematology,Maastricht University Medical Centre+,Maastricht,Netherlands
,
Yvonne Henskens
Affiliations:
Central Diagnostic Laboratory, Unit for Hemostasis and Transfusion,Maastricht University Medical Centre+,Maastricht,Netherlands
,
Paul Verhezen
Affiliations:
Central Diagnostic Laboratory, Unit for Hemostasis and Transfusion,Maastricht University Medical Centre+,Maastricht,Netherlands
,
Rick Wetzels
Affiliations:
Central Diagnostic Laboratory, Unit for Hemostasis and Transfusion,Maastricht University Medical Centre+,Maastricht,Netherlands
,
Harry Schouten
Affiliations:
Hematology,Maastricht University Medical Centre+,Maastricht,Netherlands
Erik Beckers
Affiliations:
Hematology,Maastricht University Medical Centre+,Maastricht,Netherlands
EHA Library. Heubel-Moenen F. Jun 15, 2019; 267205; PS1588
Ms. Floor Heubel-Moenen
Ms. Floor Heubel-Moenen
Contributions
Abstract

Abstract: PS1588

Type: Poster Presentation

Presentation during EHA24: On Saturday, June 15, 2019 from 17:30 - 19:00

Location: Poster area

Background
Bleeding events in chemotherapy induced thrombocytopenic (CIT) patients with similar platelet counts might be influenced by changes in clot lysis potential.

Aims
In this observational study we investigated thromboelastographic lysis parameters, alterations in clot strength and susceptibility to clot lysis in CIT patients and identified factors associated with fibrinolytic profiles. Furthermore, the effects of platelet transfusions were evaluated.

Methods
Independent determinants of tPA-ROTEM lysis parameters were identified with multivariable linear regression. Clot formation, strength and lysis parameters were compared with results of healthy individuals. Characteristics of CIT patients with and without hyperfibrinolytic profiles were compared. tPA-ROTEM results before, 1 hour and 24 hours after platelet transfusion were compared.

Results
A total of 72 consecutive CIT patients were included. tPA-ROTEM lysis parameters correlated with changes in fibrinolytic proteins. Compared to healthy individuals, clot formation time was longer, maximum clot firmness was weaker and lysis times were shorter. CIT patients had low PAI-1 and TAFI levels and forty percent exhibited hyperfibrinolytic profiles. Platelet transfusions resulted in less hyperfibrinolytic profiles in many, but not all CIT patients. Patients without hyperfibrinolytic profiles had higher fibrinogen, FVIII and a2-AP levels.

Conclusion
tPA-ROTEM can be used as a fast and reliable assay to detect hyperfibrinolytic profiles in CIT patients. CIT patients have weaker clots which are more susceptible to clot lysis compared to healthy individuals. Besides platelets, other factors are likely to influence clot susceptibility to fibrinolysis in CIT patients. The impact of a hyperfibrinolytic tPA-ROTEM profile on bleeding remains to be investigated.

Session topic: 31. Transfusion medicine

Keyword(s): Bleeding, Fibrinolysis, Thrombocytopenia

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