PLATELET COUNT AND MEAN PLATELET VOLUME IN ACUTE STROKE: A SYSTEMATIC REVIEW AND META-ANALYSIS
Author(s): ,
Houshang Amir Shemirani
Affiliations:
Division of Clinical Laboratory Science, Department of Laboratory Medicine,University of Debrecen,Debrecen,Hungary;Central Laboratory,Erzsébet Hospital,S.ujhely,Hungary
,
Farzaneh Sadeghi
Affiliations:
Division of Clinical Laboratory Science, Department of Laboratory Medicine,University of Debrecen,Debrecen,Hungary
,
Sándor Kovács
Affiliations:
Department of Research Methodology and Statistics, Institute of Sectorial Economics and Methodology,University of Debrecen,Debrecen,Hungary
,
Katalin Szilvia Zsóri
Affiliations:
Central Pharmacy,Erzsébet Hospital,S.ujhely,Hungary
,
Zsuzsanna Bereczky
Affiliations:
Division of Clinical Laboratory Science, Department of Laboratory Medicine,University of Debrecen,Debrecen,Hungary
Zoltán csiki
Affiliations:
Internal Medicine,University of Debrecen,Debrecen,Hungary
EHA Library. SHEMIRANI H. Jun 15, 2019; 267194; PS1577
Dr. Houshang Amir SHEMIRANI
Dr. Houshang Amir SHEMIRANI
Contributions
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Abstract

Abstract: PS1577

Type: Poster Presentation

Presentation during EHA24: On Saturday, June 15, 2019 from 17:30 - 19:00

Location: Poster area

Background
Changes of platelet count (PC) and mean platelet volume (MPV) could be a marker or a predictor of acute stroke (AS). 

Aims
We conducted a systematic review and meta-analysis of the published literature on the reporting of MPV and PC in AS.

Methods
Medline, EBSCOhost, Web of Science, ScienceDirect, Google Scholar and Scopus were searched for studies. Studies were included in accordance with Patient Population or Problem, Intervention, Comparison, Outcomes, and Setting (PICOS) framework. The PRISMA strategy was used to report findings. Risk of bias was assessed with Newcastle-Ottawa Scale. The inclusion criteria were case-control or cross-sectional studies, individuals suffered an acute stroke, with fatal or non-fatal stroke outcomes. Standardized mean difference (SMD) was calculated with a confidence interval of 95% (95% CI).

Results
We included 32 eligible articles retrieved from the literature. PC was significantly lower in AS patients [standardized mean difference (SMD)=₋0.30, (95%CI: ₋0.49–₋0.11), N=2492, P=0.002] compared with controls (N=3615). The MPV was significantly higher [SMD=0.51, (95%CI: 0.27–0.74), N=2413, P<0.001] compared with controls (N=3621). Subgroup analyses showed significantly lower PC in both ischemic stroke (Difference SMD=₋ 0.18, 95%CI: ₋0.35₋0.01) and hemorrhagic stroke (₋0.94, ₋1.62–₋0.25), but only samples by citrate anticoagulant showed significantly lower result for patients compared to controls (₋0.36, ₋0.68–₋0.04). Ischemic stroke patients had higher MPV (0.55, 0.29–0.81), and samples by EDTA anticoagulant showed significantly higher result for patients compared to controls (0.79, 0.49–1.10).

Conclusion
PC and MPV appeared to be significantly different between patients with AS and control populations. MPV was significantly higher in ischemic stroke and PC was significantly lower in both ischemic and hemorrhagic strokes. It is advisable to pay attention to the type of anticoagulant for hematology analyses in AS. Our results highlight the potential predictive role of PC and MPV in the occurrence of stroke.

Session topic: 34. Thrombosis and vascular biology - Biology & Translational Research

Keyword(s): Platelet activation, Platelet count, Stroke

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