EPIDEMIOLOGICAL STUDY OF IDIOPATHIC THROMBOCYTOPENIC PURPURA AMONG THE ADULT POPULATION OF THE RUSSIAN FEDERATION
Author(s): ,
Anait Melikyan
Affiliations:
Department of standardization of methods of therapy,National Research Center for Hematology,Moscow,Russian Federation
,
Elena Egorova
Affiliations:
Department of standardization of methods of therapy,National Research Center for Hematology,Moscow,Russian Federation
,
Elena Pustovaya
Affiliations:
National Research Center for Hematology,Moscow,Russian Federation
,
Tamara Kolosheinova
Affiliations:
Department of standardization of methods of therapy,National Research Center for Hematology,Moscow,Russian Federation
,
Elena Ladygina
Affiliations:
Department of standardization of methods of therapy,National Research Center for Hematology,Moscow,Russian Federation
,
Elena Volodicheva
Affiliations:
Regional Clinical Hospital,Tula,Russian Federation
,
Tatiana Kaporskaia
Affiliations:
Regional Clinical Hospital,Irkutsk,Russian Federation
,
Ridvan Ilyasov
Affiliations:
Republican Clinical Oncologic Dispensary,Simferopol,Russian Federation
,
Tatiana Shelekhova
Affiliations:
Clinic of Professional Pathology and Haematology,Saratov,Russian Federation
,
Natalia Fedorova
Affiliations:
Regional Clinical Hospital,Amursk,Russian Federation
,
Irina Zotova
Affiliations:
Russian Research Institute of Hematology and Transfusiology,Saint-Petersburg,Russian Federation
,
Tatyana Sycheva
Affiliations:
Regional Clinical Hospital,Astrachan,Russian Federation
,
Ilya Kontievskii
Affiliations:
Moscow Regional Clinical Research Institute,Mosow,Russian Federation
,
Inna Shestopalova
Affiliations:
Regional Clinical Hospital,Khabarovsk,Russian Federation
,
Nadezhda Kurkina
Affiliations:
Republican Clinical Hospital №4,Saransk,Russian Federation
,
Ekaterina Syrtseva
Affiliations:
Interdistrict Clinical Hospital №7,Krasnoyarsk,Russian Federation
,
Elena Tarasenko
Affiliations:
City hospital №1,Sevastopol,Russian Federation
,
Olimpiada Meresiy
Affiliations:
Regional Clinical Hospital,Perm,Russian Federation
,
Zhanna Cherkashenko
Affiliations:
Regional Clinical Hospital,Volgograd,Russian Federation
,
Yulia Chabaeva
Affiliations:
National Research Center for Hematology,Moscow,Russian Federation
Sergei Kulikov
Affiliations:
National Research Center for Hematology,Moscow,Russian Federation
EHA Library. Melikyan A. Jun 15, 2019; 266721; PS1104
Anait Melikyan
Anait Melikyan
Contributions
Abstract

Abstract: PS1104

Type: Poster Presentation

Presentation during EHA24: On Saturday, June 15, 2019 from 17:30 - 19:00

Location: Poster area

Background
Primary immune thrombocytopenia (idiopathic thrombocytopenic purpura - ITP) is a rare autoimmune disease, the main clinical manifestations of which are hemorrhagic syndrome of varying severity. The incidence of ITP in the adult population of different countries varies from 1.6 to 12.5/100,000 person-years. ITP register started in the Russian Federation (RF) In December 2014. This is multicenter, prospective observational cohort study “Epidemiological and clinical characteristics of ITP in adults in Russia”.

Aims
Assessment of the epidemiological characteristics of ITP in the adult population of the RF.

Methods
Clinical and laboratory data of the register “Epidemiological and clinical characteristics of ITP in adults in Russia”. Methods of descriptive statistics, frequency, variance analysis and event analysis used in statistical processing.

Results

The incidence of ITP in the adult population of the Russian Federation averaged 2.09/100,000 people. The highest morbidity of 2.7/100,000 recorded among women under 40 years of age. While in men there was a gradual increase in the incidence from 1.09 to 2.5/100,000 people over the age of 60 years. The result obtained is comparable with the data of the registers of other European countries. An analysis of incidence in the sex-age strata showed that men have a tendency to an increase in the incidence of ITP from 1.09 at the age of 40, to 2.98 at the age of 60. Similar changes in the incidence in women of different age groups not detected. It is noteworthy that in the age group over 60 years, the incidence in men and women is almost the same, whereas data from epidemiological studies in other European countries showed a significant predominance in this group of men.

There was a significant relationship between the risk of development, the degree of bleeding and the number of platelets in the onset of the disease: the severity of hemorrhagic syndrome increases with the number of platelets below 50x109/l (p<0.0001). In 92.2% of cases glucocorticosteroid hormones prescribed as the first line of therapy. Analysis of methods of treatment used as a second line therapy demonstrated that the probability of splenectomy the last 3 years decreased from 26 to 17%, while the number of patients receiving thrombopoetin receptors agonists increased from 5.9 to 45.7%.

Conclusion

The epidemiological data are comparable with those in other European countries.  Geographical variations of incidence in different regions of the Russian Federation require further study.

Session topic: 33. Bleeding disorders (congenital and acquired)

Keyword(s): Hemorrhage, Idiopathic thombocytopenic purpura (ITP)

By clicking “Accept Terms & all Cookies” or by continuing to browse, you agree to the storing of third-party cookies on your device to enhance your user experience and agree to the user terms and conditions of this learning management system (LMS).

Cookie Settings
Accept Terms & all Cookies