CLINICAL VALUE OF DIFFUSION-WEIGHTED WHOLE-BODY IMAGING WITH BACKGROUND BODY SIGNAL SUPPRESSION IN NEWLY DIAGNOSED LYMPHOMA PATIENTS
Author(s): ,
Lihong Zhang
Affiliations:
Department of Hematology,The First Affiliated Hospital of Soochow University,Suzhou,China
,
Shuo Liu
Affiliations:
Department of Hematology,The First Affiliated Hospital of Soochow University,Suzhou,China
,
Qian Zhu
Affiliations:
Department of Hematology,The First Affiliated Hospital of Soochow University,Suzhou,China
,
Depei Wu
Affiliations:
Department of Hematology,The First Affiliated Hospital of Soochow University,Suzhou,China
Haiwen Huang
Affiliations:
Department of Hematology,The First Affiliated Hospital of Soochow University,Suzhou,China
EHA Library. Huang H. Jun 14, 2019; 266115; PF315
Dr. Haiwen Huang
Dr. Haiwen Huang
Contributions
Abstract

Abstract: PF315

Type: Poster Presentation

Presentation during EHA24: On Friday, June 14, 2019 from 17:30 - 19:00

Location: Poster area

Background
18F-fluoro-2-deoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) is the widely used functional imaging method in lymphoma. Although 18F-FDG PET/CT shows a higher sensitivity for detecting lesions, it has the disadvantage of associated substantial dose of ionizing radiation and may cause radiation-induced secondary malignancies. Diffusion-weighted whole-body imaging with background body signal suppression (DWIBS), a noninvasively functional magnetic resonance imaging (MRI) technique that can probe random microscopic motion of water molecules in the body. 

Aims
In this study, we evaluate clinical value of DWIBS by comparing the accuracy of DWIBS and 18F-FDG PET/CT in the staging of newly diagnosed lymphoma patients. Further to investigate the correlation between the minimum apparent diffusion coefficient (ADCmin) and maximum standard uptake value (SUVmax), Ki-67, international prognostic index (IPI), clinical stages, serum lactate dehydrogenase (LDH) and β2-microglobulin (β2-MG).

Methods
Fifty-four newly diagnosed lymphoma patients prospectively underwent both DWIBS and 18F-FDG PET/CT. Staging was performed with WB-DWI and 18F-FDG PET/CT respectively according to the Ann Arbor stage system. For each patient, the ADCmin of the lesion was measured on the ADC map and SUVmax was measured in the lesion with high FDG uptake. The mean value of ADCmin for all measurable lesions per patient was indicated by ADCmean. Pathological specimens were immunohistochemically stained to obtain Ki-67 positive rates. Serum LDH and β2-MG level results were collected.

Results
A total of 273 lesions, 222 nodal lesions and 51 extra-nodal lesions, were detected by DWIBS. 18F-FDG PET/CT showed a total of 271 lesions involved, 207 nodal lesions and 64 extra-nodal lesions. The agreement of detecting nodal lesions between the two imaging methods was excellent (к=0.828, p<0.001). The agreement of detecting extra-nodal lesions between the two imaging methods was good (к=0.674, p<0.001). The agreement of detecting overall lesions (nodal lesions and extra-nodal lesions) between the two imaging methods was good (к=0.755, p<0.001). The two methods were concordant in the staging in 45 (83.3%) patients (к=0.755, p<0.001). DWIBS staging and clinical staging were concordant in 45 (83.3%) patients (к=0.757, p<0.001). 18F-FDG PET/CT staging and clinical staging were concordant in 47 (87.0%) patients(к=0.809, p<0.001). One hundred and ninety lesions simultaneously obtained ADCmin and SUVmax. Based on 190 lesions, ADCmin and SUVmax were inversely correlated (r=-0.222, p=0.002). There was no statistically significant difference in ADCmean between different stages and different IPI scores. There were no correlations between ADCmeanand IPI, clinical staging, LDH, β2-MG. Among 42 patients with biopsy, a significant inversely correlation was observed between ADCmin and Ki-67 of the biopsy lesions (r=-0.401 p=0.009).

Conclusion
Our results showed good agreement between DWIBS and PET/CT in staging of newly diagnosed lymphoma patients, and an inversely correlation between ADCmin and SUVmax ADCmin and the proliferation index Ki-67. Although the concordance rate between DWIBS staging and clinical staging was slightly lower than that of between PET/CT staging and clinical staging, DWIBS has the advantages of safe and efficient, affordable and non-ionization radiation. Therefore, DWIBS in the clinical application of lymphoma is still promising.

Session topic: 19. Aggressive Non-Hodgkin lymphoma - Clinical

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