Normal and leukemic hematopoiesis in the bone marrow. Metabolic regulation in a dynamic environment
EHA Library. Lapidot T. 06/17/18; 219244 Topic: 8Aa Hematopoiesis and stem cell biology
Tsvee Lapidot
Tsvee Lapidot
Learning Objectives
• learn that energy in the form of reactive oxygen species (ROS), is shared (and how) between blood and bone forming stem cells,
• learn how anti and pro coagulation factors also regulate blood and bone forming stem cells by control of nitric oxide (NO) generation, independently of coagulation, and
• learn how ROS and NO metabolism is altered in AML bone marrow (BM), and how this leads to destruction of the BM microenvironment and normal hematopoiesis.

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