Contributions
Abstract: PB2397
Type: Publication Only
Background
Von Willebrand disease is a common bleeding disorder. The wide variation in VWF levels between and within normal individuals highlights the clinical challenge of defining its cutoff value. Although studies on the influence of ethnicity on ABO phenotypes and the levels of VWF have been carried out on different ethnicities, there is a lack of such data among Arab population.
Aims
We aimed to evaluate the correlation of ABO phenotypes with all the parameters of the minimal test panel of VWF including (VWF:Ag, VWF:RCo, VWF:CB and FVIII:C), tested in a normal Arab population, and to estimate ABO specific normal reference range.
Methods
Blood samples were collected from 87 healthy donors in Riyadh to determine levels of factor VIII and VWF panel between the various ABO phenotypes.
Results
The highest mean values of factor VIII:C (128 U/dL), VWF:Ag (125 U/dL), VWF:RCo (109 U/dL), and VWF:CB (91 U/dL) were observed with type AB and the lowest mean values of factor VIII:C (81 U/dL), VWF:Ag (85 U/dL), VWF:RCo (73 U/dL), and VWF:CB (70 U/dL) corresponded to type O.
Conclusion
ABO phenotypes significantly influence plasma levels of VWF parameters in Arab nations as seen with other ethnicity. Hence, ABO specific normal ranges of the minimal test panel of VWFand factor VIII:C are essential for the appropriate prediction of mild VWD. Further study including a larger categorized sample size is required to generalize the test panel on the Arab population.
Session topic: 36. Quality of life, palliative care, ethics and health economics
Keyword(s): ABO blood group, Von Willebrand factor (vWF)
Abstract: PB2397
Type: Publication Only
Background
Von Willebrand disease is a common bleeding disorder. The wide variation in VWF levels between and within normal individuals highlights the clinical challenge of defining its cutoff value. Although studies on the influence of ethnicity on ABO phenotypes and the levels of VWF have been carried out on different ethnicities, there is a lack of such data among Arab population.
Aims
We aimed to evaluate the correlation of ABO phenotypes with all the parameters of the minimal test panel of VWF including (VWF:Ag, VWF:RCo, VWF:CB and FVIII:C), tested in a normal Arab population, and to estimate ABO specific normal reference range.
Methods
Blood samples were collected from 87 healthy donors in Riyadh to determine levels of factor VIII and VWF panel between the various ABO phenotypes.
Results
The highest mean values of factor VIII:C (128 U/dL), VWF:Ag (125 U/dL), VWF:RCo (109 U/dL), and VWF:CB (91 U/dL) were observed with type AB and the lowest mean values of factor VIII:C (81 U/dL), VWF:Ag (85 U/dL), VWF:RCo (73 U/dL), and VWF:CB (70 U/dL) corresponded to type O.
Conclusion
ABO phenotypes significantly influence plasma levels of VWF parameters in Arab nations as seen with other ethnicity. Hence, ABO specific normal ranges of the minimal test panel of VWFand factor VIII:C are essential for the appropriate prediction of mild VWD. Further study including a larger categorized sample size is required to generalize the test panel on the Arab population.
Session topic: 36. Quality of life, palliative care, ethics and health economics
Keyword(s): ABO blood group, Von Willebrand factor (vWF)