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MAY-THURNER SYNDROME AND RECURRENT DEEP VENOUS THROMBOSIS IN TWO PEDIATRIC CASE TREATED WITH DABIGATRAN ETEXILATE
Author(s): ,
mualla cetin
Affiliations:
Pediatric Hematology,HACETTEPE UNIVERSITY,Ankara,Turkey
Selin Aytac
Affiliations:
Pediatric Hematology,HACETTEPE UNIVERSITY,Ankara,Turkey
(Abstract release date: 05/17/18) EHA Library. Aytac S. 06/14/18; 216839; PB2514
Assoc. Prof. Selin Aytac
Assoc. Prof. Selin Aytac
Contributions
Abstract

Abstract: PB2514

Type: Publication Only

Background
May-Thurner Syndrome (MTS) also known as iliac vein compression syndrome is a predisposition factor for venous thromboembolism. It occurs as a result of compression of the left common iliac vein between the right common iliac artery and the vertebrae. As a result of venous congestion deep venous thrombosis develop in the left lower extremity. MTS  is diagnosed in 2-5% of all patients being evaluated for chronic venous insufficiency of the lower extremity. It is reported that MTS was more common in women and the mean age at presentation is 42.6±16.9 years. 

Aims
Here, we present two adolescent girl who was initially diagnosed as lower extremity DVT and received LMWH however their symptomps were progress under the treatment of LMWH, they both experience recurrence. Because of swelling and pain of the leg  they were both re-evaluated and diagnosed as postthrombotic syndrome. However their symptomps did not resolve and PO dabigatran etexilate was given.   

Methods
Two adolescent girl(15 and 16 years old ) who were initially diagnosed as left lower extremity DVT with postphylebitic syndrome, treated with dabigatran etexilate and their distinctive symptomps eventually disappear with this treatment however MR angiography did show MTS. Althogh they both had a history of recurrence since PO dabigatran etexilate treatment they had neither recurrence nor aggravation of symptomps for 2 years.

Results
 Several treatment modalities  have been used to treat MTS mostly based on surgical and/or endovascular interventions  in the past. More recently medical treatment approaches especially for patients with DVT were considered.

Conclusion
In conclusion leg swelling and pain  in adolescent girls with left lower extremities DVT should be evaluated for MTS.

Session topic: 35. Thrombosis and vascular biology & translational Research

Keyword(s): Deep venous thrombosis, Pediatric, Thromboembolic events, Treatment

Abstract: PB2514

Type: Publication Only

Background
May-Thurner Syndrome (MTS) also known as iliac vein compression syndrome is a predisposition factor for venous thromboembolism. It occurs as a result of compression of the left common iliac vein between the right common iliac artery and the vertebrae. As a result of venous congestion deep venous thrombosis develop in the left lower extremity. MTS  is diagnosed in 2-5% of all patients being evaluated for chronic venous insufficiency of the lower extremity. It is reported that MTS was more common in women and the mean age at presentation is 42.6±16.9 years. 

Aims
Here, we present two adolescent girl who was initially diagnosed as lower extremity DVT and received LMWH however their symptomps were progress under the treatment of LMWH, they both experience recurrence. Because of swelling and pain of the leg  they were both re-evaluated and diagnosed as postthrombotic syndrome. However their symptomps did not resolve and PO dabigatran etexilate was given.   

Methods
Two adolescent girl(15 and 16 years old ) who were initially diagnosed as left lower extremity DVT with postphylebitic syndrome, treated with dabigatran etexilate and their distinctive symptomps eventually disappear with this treatment however MR angiography did show MTS. Althogh they both had a history of recurrence since PO dabigatran etexilate treatment they had neither recurrence nor aggravation of symptomps for 2 years.

Results
 Several treatment modalities  have been used to treat MTS mostly based on surgical and/or endovascular interventions  in the past. More recently medical treatment approaches especially for patients with DVT were considered.

Conclusion
In conclusion leg swelling and pain  in adolescent girls with left lower extremities DVT should be evaluated for MTS.

Session topic: 35. Thrombosis and vascular biology & translational Research

Keyword(s): Deep venous thrombosis, Pediatric, Thromboembolic events, Treatment

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