Contributions
Abstract: PB2362
Type: Publication Only
Background
Immune Thrombocytopenia (ITP) is one of the most common hematological abnormalities in children; despite the extremely low platelet count the symptoms are generally mild. Some studies have argued that a compensatory pro-coagulant plasmatic state with a protective effect exist in these patients. Our study aims to investigate this pro-coagulant state in pediatric ITP patients.
Aims
Our study aims to investigate the bleeding tendency and pro-coagulant state in pediatric thrombocytopenic patients.
Methods
Pediatric ITP patients treated at Emek Medical Center were included. Bleeding score and laboratory parameters including platelet (Plt) count, PT- aPTT, von Willebrand factor (vWF) and Factor VIII activity at 2 different points, disease onset and during follow-up, were assessed.
Results
Thirty seven patients were included (24M/13F); median age was 3.3 (0.7-22.7) yr. Eight pts (22%) had a bleeding score of 3 (more than skin ) or more. Five patients were treated with steroids or IVIG.
Patients with an acute disease (12 mo), (p<0.025). The severity of bleeding was lower in Arab pts than in Jewish ones (p<0.02). Seventeen pts were evaluated at two time-points. The mean Plt count and vWF were 25.3 K/µl, 165.6% at point 1 and 199.1K/µl, 146.6% at point 2; respectively. Platelet count significantly increased and vWF significantly decreased between time points 1 and 2 among our patients (Z=-3.41, p<0.001; Z=2.23, p<0.03)
A compensatory pro-coagulant state with increased vWF was found in our cohort at enrollment and declined when platelet count increased. This might explain the scarcity of severe bleeding in pediatric ITP patients.
Conclusion
A compensatory pro-coagulant state with increased vWF was found in our cohort at enrollment and declined when platelet count increased. This might explain the scarcity of severe bleeding in pediatric ITP patients.
Session topic: 33. Platelets disorders
Keyword(s): Hemostasis, ITP
Abstract: PB2362
Type: Publication Only
Background
Immune Thrombocytopenia (ITP) is one of the most common hematological abnormalities in children; despite the extremely low platelet count the symptoms are generally mild. Some studies have argued that a compensatory pro-coagulant plasmatic state with a protective effect exist in these patients. Our study aims to investigate this pro-coagulant state in pediatric ITP patients.
Aims
Our study aims to investigate the bleeding tendency and pro-coagulant state in pediatric thrombocytopenic patients.
Methods
Pediatric ITP patients treated at Emek Medical Center were included. Bleeding score and laboratory parameters including platelet (Plt) count, PT- aPTT, von Willebrand factor (vWF) and Factor VIII activity at 2 different points, disease onset and during follow-up, were assessed.
Results
Thirty seven patients were included (24M/13F); median age was 3.3 (0.7-22.7) yr. Eight pts (22%) had a bleeding score of 3 (more than skin ) or more. Five patients were treated with steroids or IVIG.
Patients with an acute disease (12 mo), (p<0.025). The severity of bleeding was lower in Arab pts than in Jewish ones (p<0.02). Seventeen pts were evaluated at two time-points. The mean Plt count and vWF were 25.3 K/µl, 165.6% at point 1 and 199.1K/µl, 146.6% at point 2; respectively. Platelet count significantly increased and vWF significantly decreased between time points 1 and 2 among our patients (Z=-3.41, p<0.001; Z=2.23, p<0.03)
A compensatory pro-coagulant state with increased vWF was found in our cohort at enrollment and declined when platelet count increased. This might explain the scarcity of severe bleeding in pediatric ITP patients.
Conclusion
A compensatory pro-coagulant state with increased vWF was found in our cohort at enrollment and declined when platelet count increased. This might explain the scarcity of severe bleeding in pediatric ITP patients.
Session topic: 33. Platelets disorders
Keyword(s): Hemostasis, ITP