Contributions
Abstract: PB2363
Type: Publication Only
Background
Although the incidence of thromboembolic events has increased over the last decade, non catheter-related thromboembolism is uncommanly seen in childhood.
Aims
This study was aimed to analyze the data of 93 thromboembolic events in children who were followed up in our hematology–oncology clinic between 2000-2017, retrospectively.
Methods
Information of 93 patients were retrieved from patient files and from the records contained in the electronic information processing environment created after 2005.
Results
Fifthy four of the patients were males and 39 were females. The age range was between four months-16 years. Presenting ages of the patients were changing from one day to 12 years. Of the children 11 (11.8%) of the cases were neonates, 23 (24.7%) were infants less than 1 year old, and 59 (63.5%) were children over than one year old. Thromboembolic events were mostly located in central nervous system 54 (58.1%), deep venous system of the limbs 20 (21.6%), portal vein 9(9.8%), renal vein 2 (2.1%), intracardiac 2 ( 2.1%), inferior vena cava 2 (2.1%), peripheral artery 2 (2.1%) and pulmonary embolism 2 (2.1%). Inherited risk factors were present in 55 (48.4%) of the children. Twenty of the patients carried two risk factors (21.5%). FV Leiden heterozygosity was the most common inherited risk factor. Acquired risk factors were present in 35 (37.6%) of the children. Systemic infection was the most common underlying risk factor. Acquired and inherited risk factors were present simultaneously in 20 (21.5%) of the patients. Treatment included low-molecular-weight heparin (n=67), coumadin (n=12), heparin (n=8), aspirin(n=6).
Conclusion
Thrombosis in children is an important complication with high morbidity and mortality. Thrombosis in children is gaining increased awareness, as advanced medical care has increased treatment intensity of hospitalized pediatric patients. Better predictors of prognosis in relation to risk factors, treatment and prophylaxis are therefore urgently needed. Future respective studies may help to assess the risk profile and therapy.
Session topic: 33. Platelets disorders
Keyword(s): Children, Therapy, Thromboembolic events
Abstract: PB2363
Type: Publication Only
Background
Although the incidence of thromboembolic events has increased over the last decade, non catheter-related thromboembolism is uncommanly seen in childhood.
Aims
This study was aimed to analyze the data of 93 thromboembolic events in children who were followed up in our hematology–oncology clinic between 2000-2017, retrospectively.
Methods
Information of 93 patients were retrieved from patient files and from the records contained in the electronic information processing environment created after 2005.
Results
Fifthy four of the patients were males and 39 were females. The age range was between four months-16 years. Presenting ages of the patients were changing from one day to 12 years. Of the children 11 (11.8%) of the cases were neonates, 23 (24.7%) were infants less than 1 year old, and 59 (63.5%) were children over than one year old. Thromboembolic events were mostly located in central nervous system 54 (58.1%), deep venous system of the limbs 20 (21.6%), portal vein 9(9.8%), renal vein 2 (2.1%), intracardiac 2 ( 2.1%), inferior vena cava 2 (2.1%), peripheral artery 2 (2.1%) and pulmonary embolism 2 (2.1%). Inherited risk factors were present in 55 (48.4%) of the children. Twenty of the patients carried two risk factors (21.5%). FV Leiden heterozygosity was the most common inherited risk factor. Acquired risk factors were present in 35 (37.6%) of the children. Systemic infection was the most common underlying risk factor. Acquired and inherited risk factors were present simultaneously in 20 (21.5%) of the patients. Treatment included low-molecular-weight heparin (n=67), coumadin (n=12), heparin (n=8), aspirin(n=6).
Conclusion
Thrombosis in children is an important complication with high morbidity and mortality. Thrombosis in children is gaining increased awareness, as advanced medical care has increased treatment intensity of hospitalized pediatric patients. Better predictors of prognosis in relation to risk factors, treatment and prophylaxis are therefore urgently needed. Future respective studies may help to assess the risk profile and therapy.
Session topic: 33. Platelets disorders
Keyword(s): Children, Therapy, Thromboembolic events