Contributions
Abstract: PB2057
Type: Publication Only
Background
Bacterial infections and febrile neutropenia are major causes of morbidity and mortality in patients with hematological malignancy.
Aims
The aim of this study was to investigate the incidence and risk factors of infections in lymphoma patients.
Methods
This retrospective study was conducted on 200 lymphoma patients diagnosed and treated between January 2009 and December 2017 in Diskapi Yildirim Beyazit Training and Research Hospital, a tertiary referral hospital in Ankara, Turkey. A total of 65 patients developed at least one infection episode (IE) while 37 patients developed febrile neutropenia (FN).
Results
The mean follow-up period was 20.09±19.81 months. The incidence of IE was 32.5% (65/200) and FN was 18.5% (37/200). Analysis of the data revealed that the patients with IE had significantly higher diagnosis of central nervous system lymphoma (CNSL), lower baseline hemoglobin, lower baseline hematocrit, higher baseline lactate dehydrogenase levels, higher usage of central cathater, and a higher number of chemotherapy lines compared to patients with no IE. In logistic regression analysis, disease subtype of CNSL, usage of central catheter and LDH were found to increase the risk of infection. The OR for CNSL was 37.866 (p=0.003), 2.679 for central catheter (p=0.008) and 1.001 for LDH (p=0.011).
Conclusion
The risk of infection in patients with lymphoma was associated with central catheter usage, higher LDH levels and a diagnosis of CNSL. Baseline hematological parameters were not determined to have any impact on the occurrence of infection. Clinicians must be aware of these data soon after diagnosis as they will be required for the management of lymphoma patients through the whole period.
Session topic: 31. Infectious diseases, supportive care
Keyword(s): Infection, lymphoma, Risk factor
Abstract: PB2057
Type: Publication Only
Background
Bacterial infections and febrile neutropenia are major causes of morbidity and mortality in patients with hematological malignancy.
Aims
The aim of this study was to investigate the incidence and risk factors of infections in lymphoma patients.
Methods
This retrospective study was conducted on 200 lymphoma patients diagnosed and treated between January 2009 and December 2017 in Diskapi Yildirim Beyazit Training and Research Hospital, a tertiary referral hospital in Ankara, Turkey. A total of 65 patients developed at least one infection episode (IE) while 37 patients developed febrile neutropenia (FN).
Results
The mean follow-up period was 20.09±19.81 months. The incidence of IE was 32.5% (65/200) and FN was 18.5% (37/200). Analysis of the data revealed that the patients with IE had significantly higher diagnosis of central nervous system lymphoma (CNSL), lower baseline hemoglobin, lower baseline hematocrit, higher baseline lactate dehydrogenase levels, higher usage of central cathater, and a higher number of chemotherapy lines compared to patients with no IE. In logistic regression analysis, disease subtype of CNSL, usage of central catheter and LDH were found to increase the risk of infection. The OR for CNSL was 37.866 (p=0.003), 2.679 for central catheter (p=0.008) and 1.001 for LDH (p=0.011).
Conclusion
The risk of infection in patients with lymphoma was associated with central catheter usage, higher LDH levels and a diagnosis of CNSL. Baseline hematological parameters were not determined to have any impact on the occurrence of infection. Clinicians must be aware of these data soon after diagnosis as they will be required for the management of lymphoma patients through the whole period.
Session topic: 31. Infectious diseases, supportive care
Keyword(s): Infection, lymphoma, Risk factor