Contributions
Abstract: PB2074
Type: Publication Only
Background
revalence of iron deficiency (IDA) are staggering: 2 billion people, i.e. more than 30% of the world's population suffer from that. IDA is one of the most studied pathological condition. It is "the most grateful anemia" and after normalization of diet, adequate ferrotherapy and treatment of the digestive tract relapses should not happens. The most difficult is to understand causes of recurrence IDA in previously examined and treated patients with no obvious reason.
Aims
Our aim is to describe the clinical case of recurrent iron-deficiency anemia presumably autoimmune etiology in 17 year old girl.
Methods
| Determination of specific antibodies to human-ferritin by the method of detection of lupus anticoagulant in patients with prolonged APTT. Ferritin of the patient was 0,008 ng/ml.The ferrinin of the control sample was 171 ng/ml. After mixing in equal proportions plasma of the patient and control, incubation for two hours ,the level of ferritin in the control sample decreased from 171 to 51 ng/ ml. We do not have in Russia Anti-Ferritin antibody. |
Results
| The patient had history of 5 years long IDA. All possible examinations were made, there was no bleeding, malnutrition or hereditary IDA. At the time of admission her blood test was - HB 47g/l, МСV 54,Ret-Hb-14%. As we have found "anti ferritin" antibody by our original method it was chosen intravenous immunoglobulin(IVIG) at a dose of 2 mg/kg for treatment. Simultaneously with the treatment IVIG our patient received iron supplementation. The treatment was successful. On day 14, the HB level increased to 106 g/l. One month after the treatment HB was 126g/l, erythrocytes-4,3 X10/12/l, MCV 83, 346 MCHC, MCH 28, Ret-Hb -29%, ferritin 146 ng/ml. |
Conclusion
Conclusions: There are a lot of immune disease in our century. We can not forget about it when we treat patients with reccurent IDA. Sometimes anti ferritin antibodies may be very useful. And if there are no anti ferritin antibodies in your countries we offer to make the incubation with control as we did.
Session topic: 30. Iron metabolism, deficiency and overload
Keyword(s): Autoimmunity, Clinical data, Iron
Abstract: PB2074
Type: Publication Only
Background
revalence of iron deficiency (IDA) are staggering: 2 billion people, i.e. more than 30% of the world's population suffer from that. IDA is one of the most studied pathological condition. It is "the most grateful anemia" and after normalization of diet, adequate ferrotherapy and treatment of the digestive tract relapses should not happens. The most difficult is to understand causes of recurrence IDA in previously examined and treated patients with no obvious reason.
Aims
Our aim is to describe the clinical case of recurrent iron-deficiency anemia presumably autoimmune etiology in 17 year old girl.
Methods
| Determination of specific antibodies to human-ferritin by the method of detection of lupus anticoagulant in patients with prolonged APTT. Ferritin of the patient was 0,008 ng/ml.The ferrinin of the control sample was 171 ng/ml. After mixing in equal proportions plasma of the patient and control, incubation for two hours ,the level of ferritin in the control sample decreased from 171 to 51 ng/ ml. We do not have in Russia Anti-Ferritin antibody. |
Results
| The patient had history of 5 years long IDA. All possible examinations were made, there was no bleeding, malnutrition or hereditary IDA. At the time of admission her blood test was - HB 47g/l, МСV 54,Ret-Hb-14%. As we have found "anti ferritin" antibody by our original method it was chosen intravenous immunoglobulin(IVIG) at a dose of 2 mg/kg for treatment. Simultaneously with the treatment IVIG our patient received iron supplementation. The treatment was successful. On day 14, the HB level increased to 106 g/l. One month after the treatment HB was 126g/l, erythrocytes-4,3 X10/12/l, MCV 83, 346 MCHC, MCH 28, Ret-Hb -29%, ferritin 146 ng/ml. |
Conclusion
Conclusions: There are a lot of immune disease in our century. We can not forget about it when we treat patients with reccurent IDA. Sometimes anti ferritin antibodies may be very useful. And if there are no anti ferritin antibodies in your countries we offer to make the incubation with control as we did.
Session topic: 30. Iron metabolism, deficiency and overload
Keyword(s): Autoimmunity, Clinical data, Iron