Contributions
Abstract: PB2072
Type: Publication Only
Background
Breath-holding spell (BHS) is a prevalent, nonepileptic, recurrent, potentially frightening early childhood disease with varying clinical manifestations. In addition to underlying genetic predisposition, dysregulation of central nervous system (CNS) is responsible for BHS. Autonomic dysfunction which leads to cardiac arrest, and cerebral anoxia, and increased vagal tonus play roles in its pathogenesis. It may accompany iron deficiency anemia (IDA). In cases with BHS, increase in corrected QT (QTc), and QTc dispersion (QTcd) which are electrocardiographic (ECG) reflection of regional differences in myocardial repolarization have been demonstrated.
Aims
In our study, we determined whether BHS develops as a result of dysrhytmia secondary to abnormal ventricular depolarization inherent to the disease, or as an outcome of IDA.
Methods
Study groups were formulated prospectively. BHS-IDA group consisted of cyanotic children aged between 9 and 60 months. The cases were evaluated in 3 groups as follows: Group 1 (Group BHS-IDA, n: 12), Group 2 (Group IDA without BHS, n: 34), Group 3 (Healthy control group, n: 26). ECGs were evaluated by the same pediatric cardiologist at one session. The difference between the longest, and the shortest QTc intervals was accepted as QTcd. Cases in all three groups were compared as for QTc, and QTcd values. Statistically analysis was performed using Student’s t, and Mann-Whitney U tests, and p<0.05 was accepted as the level of statistical significance.
Results
QTc intervals were 412.5±19.1 ms in Groups 1, 394.4±27.1 ms in Group 2, and 395.8±20.2 ms in Group 3. QTcd intervals in children diagnosed as BHS-IDA 12.0±6.5 ms, IDA 16.4±10.5 ms, and healthy control group 27.6±9.0 ms were as indicated (p>0.05).
Conclusion
IDA may affect cardiac, and nervous system which play an important role in changing autonomic nervous system balance. It induces hypoxia which leads to dysrhytmia. However in cases with BHS, ventricular repolarization which develops as a result of autonomic dysregulation, and increased vagal stimulation may differ.
Session topic: 30. Iron metabolism, deficiency and overload
Keyword(s): Iron deficiency anemia
Abstract: PB2072
Type: Publication Only
Background
Breath-holding spell (BHS) is a prevalent, nonepileptic, recurrent, potentially frightening early childhood disease with varying clinical manifestations. In addition to underlying genetic predisposition, dysregulation of central nervous system (CNS) is responsible for BHS. Autonomic dysfunction which leads to cardiac arrest, and cerebral anoxia, and increased vagal tonus play roles in its pathogenesis. It may accompany iron deficiency anemia (IDA). In cases with BHS, increase in corrected QT (QTc), and QTc dispersion (QTcd) which are electrocardiographic (ECG) reflection of regional differences in myocardial repolarization have been demonstrated.
Aims
In our study, we determined whether BHS develops as a result of dysrhytmia secondary to abnormal ventricular depolarization inherent to the disease, or as an outcome of IDA.
Methods
Study groups were formulated prospectively. BHS-IDA group consisted of cyanotic children aged between 9 and 60 months. The cases were evaluated in 3 groups as follows: Group 1 (Group BHS-IDA, n: 12), Group 2 (Group IDA without BHS, n: 34), Group 3 (Healthy control group, n: 26). ECGs were evaluated by the same pediatric cardiologist at one session. The difference between the longest, and the shortest QTc intervals was accepted as QTcd. Cases in all three groups were compared as for QTc, and QTcd values. Statistically analysis was performed using Student’s t, and Mann-Whitney U tests, and p<0.05 was accepted as the level of statistical significance.
Results
QTc intervals were 412.5±19.1 ms in Groups 1, 394.4±27.1 ms in Group 2, and 395.8±20.2 ms in Group 3. QTcd intervals in children diagnosed as BHS-IDA 12.0±6.5 ms, IDA 16.4±10.5 ms, and healthy control group 27.6±9.0 ms were as indicated (p>0.05).
Conclusion
IDA may affect cardiac, and nervous system which play an important role in changing autonomic nervous system balance. It induces hypoxia which leads to dysrhytmia. However in cases with BHS, ventricular repolarization which develops as a result of autonomic dysregulation, and increased vagal stimulation may differ.
Session topic: 30. Iron metabolism, deficiency and overload
Keyword(s): Iron deficiency anemia