Contributions
Abstract: PB2073
Type: Publication Only
Background
Anemia is a major health concern globally, yet devastating for the developing countries. Iron deficiency considers contributing 70% of total nutritional deficiencies and 30% are said to be due to vitamin B12/ folate and deficiency of other micronutrients. Iron deficiency and megaloblastic anemia cause variations in haemoglobin A2 levels which may lead to misdiagnosis. It has a financial and psychological implication to that person. True prevalence of iron or vitamin B12 / folate deficiency is uncertain in our population.
Aims
This study aim to determine iron and vitamin B12 / folate deficiency in samples received for haemoglobinopathy screening
Methods
Retrospective review of first 200 chromatograms and peripheral blood film of samples received for haemoglobinopathy screen by HPLC (High performance liquid chromatography) during the February 2016 at Section of Haematology, Department of Pathology & Laboratory Medicine, Aga Khan University Hospital Karachi. Cases with haemoglobinopathies and with alternative diagnosis like malaria, leukemia and pancytopenia were excluded from this study
Results
Total 200 consecutive chromatograms and peripheral blood films of samples were reviewed retrospectively. Out of these 200 cases 47% cases, (n=94) showed nutritional deficiency with female to male ratio of 2:1 and mean age of 13 years. Among these 47% cases, 44.5% cases (n=89) showed iron deficiency with 5% suspicion of suppressed haemoglobin A2 levels. Vitamin B12/ folate deficiency was found in 2.5% (n=5) of cases with raised haemoglobin A2 levels.
Conclusion
Nutritional deficiency was found in 47% cases in current study. This is an ongoing study, further data will be included while completion of a study period. Authors recommend treating an underlying nutritional deficiency prior to haemoglobinopathy screen
Session topic: 30. Iron metabolism, deficiency and overload
Abstract: PB2073
Type: Publication Only
Background
Anemia is a major health concern globally, yet devastating for the developing countries. Iron deficiency considers contributing 70% of total nutritional deficiencies and 30% are said to be due to vitamin B12/ folate and deficiency of other micronutrients. Iron deficiency and megaloblastic anemia cause variations in haemoglobin A2 levels which may lead to misdiagnosis. It has a financial and psychological implication to that person. True prevalence of iron or vitamin B12 / folate deficiency is uncertain in our population.
Aims
This study aim to determine iron and vitamin B12 / folate deficiency in samples received for haemoglobinopathy screening
Methods
Retrospective review of first 200 chromatograms and peripheral blood film of samples received for haemoglobinopathy screen by HPLC (High performance liquid chromatography) during the February 2016 at Section of Haematology, Department of Pathology & Laboratory Medicine, Aga Khan University Hospital Karachi. Cases with haemoglobinopathies and with alternative diagnosis like malaria, leukemia and pancytopenia were excluded from this study
Results
Total 200 consecutive chromatograms and peripheral blood films of samples were reviewed retrospectively. Out of these 200 cases 47% cases, (n=94) showed nutritional deficiency with female to male ratio of 2:1 and mean age of 13 years. Among these 47% cases, 44.5% cases (n=89) showed iron deficiency with 5% suspicion of suppressed haemoglobin A2 levels. Vitamin B12/ folate deficiency was found in 2.5% (n=5) of cases with raised haemoglobin A2 levels.
Conclusion
Nutritional deficiency was found in 47% cases in current study. This is an ongoing study, further data will be included while completion of a study period. Authors recommend treating an underlying nutritional deficiency prior to haemoglobinopathy screen
Session topic: 30. Iron metabolism, deficiency and overload