Contributions
Abstract: PB1985
Type: Publication Only
Background
A central feature of embryonic and fetal development is widespread cell division; folate is central because of its role in nucleic acid synthesis. During gestation folate deficiency can impair cellular growth and replication in the fetus or placenta. Low birth weight is closely associated with inhibited growth and cognitive development, and chronic diseases later in life.Many researches found a relationship between umbilical cord folate status and intrauterine growth restriction. In sudan no similar study was found.
Aims
It was a case-control study aimed to measure folate levels among groups of normal and low birth weight neonate to evaluate the correlation between umbilical cord folate levels and birth weight.
Methods
Haematological parameters were measured using automated cell counter,microscopic examination of peripheral blood smears and reticulocytes preparations.
Serum and red cell folate were measured by electrochemiluminscence technology (cobas e 411 analyzer) .Statistical analysis was done using SPSS program version 20.
Results
From the study it was found that umbilical cord RBC folate status to be an important predictor of neoborn birth weight, with increasing cord RBC folate being associated with increasing neoborn birth weight. Statistically significant association was found between red blood cell folate levels and birth weight (P value of 0.047 in case group). Thirteen out of 43 cases had low red cell folate levels . This indicates the presence of relationship between folate levels in fetus and birth weight. No statistically significant association was found between levels of serum folate and birth weight in the case group (P Value 0.59 in case group).This may be due to fact that serum folate is a marker of recent dietary intake and it is subjected to prandial variation.
Conclusion
Conclusions
-Red blood cell folate is considered the most reliable biomarker of folate status, as it reflects tissue folate stores.
- A single measurement of serum/plasma folate reflects only the time of blood collection and cannot differentiate between occasional low dietary intake of the vitamin and folate deficiency.
- Our study revealed that there is clear association between folate deficiency and increase incidence of low birth weight and preterm delivery.
Session topic: 29. Enzymopathies, membranopathies and other anemias
Abstract: PB1985
Type: Publication Only
Background
A central feature of embryonic and fetal development is widespread cell division; folate is central because of its role in nucleic acid synthesis. During gestation folate deficiency can impair cellular growth and replication in the fetus or placenta. Low birth weight is closely associated with inhibited growth and cognitive development, and chronic diseases later in life.Many researches found a relationship between umbilical cord folate status and intrauterine growth restriction. In sudan no similar study was found.
Aims
It was a case-control study aimed to measure folate levels among groups of normal and low birth weight neonate to evaluate the correlation between umbilical cord folate levels and birth weight.
Methods
Haematological parameters were measured using automated cell counter,microscopic examination of peripheral blood smears and reticulocytes preparations.
Serum and red cell folate were measured by electrochemiluminscence technology (cobas e 411 analyzer) .Statistical analysis was done using SPSS program version 20.
Results
From the study it was found that umbilical cord RBC folate status to be an important predictor of neoborn birth weight, with increasing cord RBC folate being associated with increasing neoborn birth weight. Statistically significant association was found between red blood cell folate levels and birth weight (P value of 0.047 in case group). Thirteen out of 43 cases had low red cell folate levels . This indicates the presence of relationship between folate levels in fetus and birth weight. No statistically significant association was found between levels of serum folate and birth weight in the case group (P Value 0.59 in case group).This may be due to fact that serum folate is a marker of recent dietary intake and it is subjected to prandial variation.
Conclusion
Conclusions
-Red blood cell folate is considered the most reliable biomarker of folate status, as it reflects tissue folate stores.
- A single measurement of serum/plasma folate reflects only the time of blood collection and cannot differentiate between occasional low dietary intake of the vitamin and folate deficiency.
- Our study revealed that there is clear association between folate deficiency and increase incidence of low birth weight and preterm delivery.
Session topic: 29. Enzymopathies, membranopathies and other anemias