Contributions
Abstract: PB2505
Type: Publication Only
Background
Cardiac complications due to iron accumulation in the patients with beta-thalassemia major (B-TM) are the main causes of death.
Aims
The study aims to demonstrate the relationship between cardiac T2* MRI and serum ferritin accumulation in children with B-TM.
Methods
The study involves 27 patients (11 females, 40.7% and 16 males, 59.3%). The ages of the patients range from 9 to 19 years (13.5±3). All of the patients included in the study received the chelation treatment.
Results
The mean value of ferritin was 2794±2162 ng/ml (509-10795 ng/ml). The mean cardiac T2* MRI value was 28.2±9.9 ms (5.42-41.9 ms) while the mean liver T2* MRI value was 5.2±6.6 ms. The mean value of pre-transfusion hemoglobin was 8.8±0.7 g/dl. Statistical significance was found between the cardiac T2* value and age (p = 0.019). Five patients with the cardiac iron accumulation had relatively higher ferritin levels but with no significant correlation.
Conclusion
In conclusion, it was seen that the cardiac iron accumulation in the patients with B-TM was age-related. Serum ferritin levels were not found to be useful enough to show cardiac iron accumulation.
Session topic: 28. Thalassemias
Keyword(s): Chelation, Ferritin, MRI, Thalassemia
Abstract: PB2505
Type: Publication Only
Background
Cardiac complications due to iron accumulation in the patients with beta-thalassemia major (B-TM) are the main causes of death.
Aims
The study aims to demonstrate the relationship between cardiac T2* MRI and serum ferritin accumulation in children with B-TM.
Methods
The study involves 27 patients (11 females, 40.7% and 16 males, 59.3%). The ages of the patients range from 9 to 19 years (13.5±3). All of the patients included in the study received the chelation treatment.
Results
The mean value of ferritin was 2794±2162 ng/ml (509-10795 ng/ml). The mean cardiac T2* MRI value was 28.2±9.9 ms (5.42-41.9 ms) while the mean liver T2* MRI value was 5.2±6.6 ms. The mean value of pre-transfusion hemoglobin was 8.8±0.7 g/dl. Statistical significance was found between the cardiac T2* value and age (p = 0.019). Five patients with the cardiac iron accumulation had relatively higher ferritin levels but with no significant correlation.
Conclusion
In conclusion, it was seen that the cardiac iron accumulation in the patients with B-TM was age-related. Serum ferritin levels were not found to be useful enough to show cardiac iron accumulation.
Session topic: 28. Thalassemias
Keyword(s): Chelation, Ferritin, MRI, Thalassemia