Contributions
Abstract: PB2506
Type: Publication Only
Background
In Egypt there are 10,000 registered thalassemia (thal) cases and more than 20,000 non-registered cases. In patients without thal the diabetogenic effects of altered zinc status had been observed while almost 9% of the Egyptian population at risk of zinc deficiency.
Aims
This study aimed at finding out the relationship between the zinc status and insulin resistance in thal children.
Methods
40 thal children (21 males, 9.9 +/_3.9 years) and 40 healthy ones (20 males, 11.4 +/_ 3.1 years) where tested for serum zinc level, oral glucose tolerance test, fasting blood glucose and serum insulin with calculation of HOMA-IR.
Results
Mean zinc level wasn’t significantly different between thal (74.63+/- 19.37) and non thal children (81.03+/-15.44) (p = 0.106), but zinc deficiency were more prevalent in thal children than the healthy ones with 32.5, and 15 % respectively (p = 0.023). Only insignificant percentage of the study (8%) and the control groups (2%) had impaired glucose tolerance test (p = 0.087). Using HOMA-IR test 20 and 22.5 % of thal children had intermediate and resistant levels compared to only 12.5 and 2.5 % of non thal children (p = 0.01). No significant correlation was found between the serum zinc level and HOMA- IR (r -0.023, p = 0.86).
Conclusion
zinc deficiency and insulin resistance were more common in thal children, but zinc deficiency didn’t significantly increase the risk of insulin resistance.
Session topic: 28. Thalassemias
Keyword(s): Zinc, Thalassemia
Abstract: PB2506
Type: Publication Only
Background
In Egypt there are 10,000 registered thalassemia (thal) cases and more than 20,000 non-registered cases. In patients without thal the diabetogenic effects of altered zinc status had been observed while almost 9% of the Egyptian population at risk of zinc deficiency.
Aims
This study aimed at finding out the relationship between the zinc status and insulin resistance in thal children.
Methods
40 thal children (21 males, 9.9 +/_3.9 years) and 40 healthy ones (20 males, 11.4 +/_ 3.1 years) where tested for serum zinc level, oral glucose tolerance test, fasting blood glucose and serum insulin with calculation of HOMA-IR.
Results
Mean zinc level wasn’t significantly different between thal (74.63+/- 19.37) and non thal children (81.03+/-15.44) (p = 0.106), but zinc deficiency were more prevalent in thal children than the healthy ones with 32.5, and 15 % respectively (p = 0.023). Only insignificant percentage of the study (8%) and the control groups (2%) had impaired glucose tolerance test (p = 0.087). Using HOMA-IR test 20 and 22.5 % of thal children had intermediate and resistant levels compared to only 12.5 and 2.5 % of non thal children (p = 0.01). No significant correlation was found between the serum zinc level and HOMA- IR (r -0.023, p = 0.86).
Conclusion
zinc deficiency and insulin resistance were more common in thal children, but zinc deficiency didn’t significantly increase the risk of insulin resistance.
Session topic: 28. Thalassemias
Keyword(s): Zinc, Thalassemia