Contributions
Abstract: PB2490
Type: Publication Only
Background
In our population the incidence of β-thalassemia minor (TM) is 2.1 percent. These cases are frequently evaluated as iron deficiency anemia (IDA) and receive iron containing medications. In cases with IDA, and β-thalassemia major, electrocardiographic (ECG) signs reflecting cardiac autonomic dysfunction, and changes in depolarization, and repolarization differ widely.
Aims
We haven’t encountered any study related to changes in ECG signs in the literature. So we wanted to investigate corrected QT (QTc), and QTc dispersion (QTcd) in cases with TM which demonstrate clinical manifestations in between IDA, and β-thalassemia major.
Methods
Study population consisted of Group 1 (TM; n:15), Group 2 (IDA; n:17), and Group 3 (healthy control; n:13). Mean ages of Groups 1, 2 and 3 were 10.2±17.4, 13.2±14.5, and 13.5±2.5 months, respectively. In all cases whole blood cell counts, levels of serum iron, iron binding capacity, and ferritin were evaluated, and hemoglobin electrophoresis was performed. Peak heart rate, RR, PR, QRS, QT, QTc and QTcd were calculated using 12-lead ECG. Groups in all 3 groups were compared as for all ECG variables.
Results
QTc intervals were estimated for TM (383.7±40.7 ms), IDA (399.1±20.4 ms), and healthy control (403.8±20.6 ms) groups as indicated. QTc intervals in cases diagnosed as TM were shorter relative to IDA, and healthy control groups. A statistically significant difference was detected between TM, and healthy control groups (p<0.05). QTc interval was statistically significantly longer in cases diagnosed as TM (84.6±34.5) ms when compared with cases with IDA (61.7±37.0 ms) (p<0.05). The other parametres did not differ between groups.
Conclusion
Changes in ECG tracings may occur not only in heart diseases, but also it may become manifest as a sign of myocardial ischemia due to anemia. In order to be able to explain some electrocardiographic changes in cases diagnosed as TM caused by etiological factors other than myocardial ischemia, and accumulation of iron, further studies should be carried out with greater number of patients.
Session topic: 28. Thalassemias
Keyword(s): Thalassemia
Abstract: PB2490
Type: Publication Only
Background
In our population the incidence of β-thalassemia minor (TM) is 2.1 percent. These cases are frequently evaluated as iron deficiency anemia (IDA) and receive iron containing medications. In cases with IDA, and β-thalassemia major, electrocardiographic (ECG) signs reflecting cardiac autonomic dysfunction, and changes in depolarization, and repolarization differ widely.
Aims
We haven’t encountered any study related to changes in ECG signs in the literature. So we wanted to investigate corrected QT (QTc), and QTc dispersion (QTcd) in cases with TM which demonstrate clinical manifestations in between IDA, and β-thalassemia major.
Methods
Study population consisted of Group 1 (TM; n:15), Group 2 (IDA; n:17), and Group 3 (healthy control; n:13). Mean ages of Groups 1, 2 and 3 were 10.2±17.4, 13.2±14.5, and 13.5±2.5 months, respectively. In all cases whole blood cell counts, levels of serum iron, iron binding capacity, and ferritin were evaluated, and hemoglobin electrophoresis was performed. Peak heart rate, RR, PR, QRS, QT, QTc and QTcd were calculated using 12-lead ECG. Groups in all 3 groups were compared as for all ECG variables.
Results
QTc intervals were estimated for TM (383.7±40.7 ms), IDA (399.1±20.4 ms), and healthy control (403.8±20.6 ms) groups as indicated. QTc intervals in cases diagnosed as TM were shorter relative to IDA, and healthy control groups. A statistically significant difference was detected between TM, and healthy control groups (p<0.05). QTc interval was statistically significantly longer in cases diagnosed as TM (84.6±34.5) ms when compared with cases with IDA (61.7±37.0 ms) (p<0.05). The other parametres did not differ between groups.
Conclusion
Changes in ECG tracings may occur not only in heart diseases, but also it may become manifest as a sign of myocardial ischemia due to anemia. In order to be able to explain some electrocardiographic changes in cases diagnosed as TM caused by etiological factors other than myocardial ischemia, and accumulation of iron, further studies should be carried out with greater number of patients.
Session topic: 28. Thalassemias
Keyword(s): Thalassemia