Contributions
Abstract: PB1991
Type: Publication Only
Background
Combined immunodeficiency (CID) is a primary immunodeficiency diseases with severe loss of T and B lymphocyte function. Lymphopenia is an important finding in diagnosis of CID.
Aims
We planned the screening of lymphopenia in cord blood samples during labor for diagnosis of CID.
Methods
Complete blood count (CBC) was measured in cord blood sample of every baby born in our hospital from january to december 2018. If lymphocyte count was below 3000/mm3, it was accepted as neonatal lymphopenia. Immunological investigations including serum immunoglobulin levels, lymphocyte subgroups and chest radiography for thymus shadow were evaluated in newborns who had lymphopenia.
Results
In this study, CBC was measured in 1500 cord blood samples during labor and lymphopenia was found in 39 of them. Mean lymphocyte count was calculated as 2250/mm3 (range:1550-4400). Two of 39 newborns with lymphopenia had CID according to immunological investigations. One patient with CID had RAG 1 defiency. It is expected the result of genetical analysis of other patient with CID.
Conclusion
The lymphopenia can occur may included infectious,genetic, systemic and iatrogenic causes. Early diagnosis of CID can be life saving, so that neonatal screening of lymphopenia is important for early diagnosis of CID.
Session topic: 24. Hematopoiesis, stem cells and microenvironment
Keyword(s): Immune deficiency, Lymphocyte, Neonate
Abstract: PB1991
Type: Publication Only
Background
Combined immunodeficiency (CID) is a primary immunodeficiency diseases with severe loss of T and B lymphocyte function. Lymphopenia is an important finding in diagnosis of CID.
Aims
We planned the screening of lymphopenia in cord blood samples during labor for diagnosis of CID.
Methods
Complete blood count (CBC) was measured in cord blood sample of every baby born in our hospital from january to december 2018. If lymphocyte count was below 3000/mm3, it was accepted as neonatal lymphopenia. Immunological investigations including serum immunoglobulin levels, lymphocyte subgroups and chest radiography for thymus shadow were evaluated in newborns who had lymphopenia.
Results
In this study, CBC was measured in 1500 cord blood samples during labor and lymphopenia was found in 39 of them. Mean lymphocyte count was calculated as 2250/mm3 (range:1550-4400). Two of 39 newborns with lymphopenia had CID according to immunological investigations. One patient with CID had RAG 1 defiency. It is expected the result of genetical analysis of other patient with CID.
Conclusion
The lymphopenia can occur may included infectious,genetic, systemic and iatrogenic causes. Early diagnosis of CID can be life saving, so that neonatal screening of lymphopenia is important for early diagnosis of CID.
Session topic: 24. Hematopoiesis, stem cells and microenvironment
Keyword(s): Immune deficiency, Lymphocyte, Neonate