Contributions
Abstract: PB2467
Type: Publication Only
Background
In patients with myeloma and lymphoma, stem cell mobilization can be unsuccessful in 5-30 % of the cases. The underlying mechanisms may include qualitative and quantitative differences among hematopoietic stem cells in the bone marrow, differences in the migration ability of hematopoietic stem cells or weakened response to G-CSF.
Aims
to compare of results of peripheral stem cell mobilization of patients with multiple myeloma and lymphoma in late middle age (55-64 years) versus old age (older than 65 years).
Methods
Patients were divided into two groups as middle age (55-64 years) (n=101), and old age (older than 65 years) (n=102).We retrospectively reviewed the data of 159 multiple myeloma patients and 44 lymphoma patients who have been mobilized between September 2010 and June 2016 in the bone marrow transplantation center
Results
The median number of peripheral blood CD34+ cell was 24.3×109 CD34+ cells/L in the middle age group, 20.0×109 CD34+ cells/L in the old age group, and there was no significant difference between the two groups. Two groups do not differ from each other in the terms of neutrophil and platelet engraftment times (p=0.702, and 0.113, respectively). The median number of CD34+ cells collected was 9.55×109 CD34+ cells/L in the middle age group, 9.20×109 CD34+ cells/L in the old age group, and there was no significant difference between the two groups. Even if the quantity of CD34+ cells collected in elderly patients was lower than in younger patients, this quantity does not reach significance.
Conclusion
the analysis of our data showed that the age of the patients has no impact on the mobilization of stem cells in lymphoma and myeloma patients. Even if the quantity of CD34+ cells collected in elderly patients was lower than in younger patients, this quantity does not reach significant difference.
Session topic: 23. Stem cell transplantation - Clinical
Keyword(s): Age, lymphoma, Myeloma, Stem cell mobilization
Abstract: PB2467
Type: Publication Only
Background
In patients with myeloma and lymphoma, stem cell mobilization can be unsuccessful in 5-30 % of the cases. The underlying mechanisms may include qualitative and quantitative differences among hematopoietic stem cells in the bone marrow, differences in the migration ability of hematopoietic stem cells or weakened response to G-CSF.
Aims
to compare of results of peripheral stem cell mobilization of patients with multiple myeloma and lymphoma in late middle age (55-64 years) versus old age (older than 65 years).
Methods
Patients were divided into two groups as middle age (55-64 years) (n=101), and old age (older than 65 years) (n=102).We retrospectively reviewed the data of 159 multiple myeloma patients and 44 lymphoma patients who have been mobilized between September 2010 and June 2016 in the bone marrow transplantation center
Results
The median number of peripheral blood CD34+ cell was 24.3×109 CD34+ cells/L in the middle age group, 20.0×109 CD34+ cells/L in the old age group, and there was no significant difference between the two groups. Two groups do not differ from each other in the terms of neutrophil and platelet engraftment times (p=0.702, and 0.113, respectively). The median number of CD34+ cells collected was 9.55×109 CD34+ cells/L in the middle age group, 9.20×109 CD34+ cells/L in the old age group, and there was no significant difference between the two groups. Even if the quantity of CD34+ cells collected in elderly patients was lower than in younger patients, this quantity does not reach significance.
Conclusion
the analysis of our data showed that the age of the patients has no impact on the mobilization of stem cells in lymphoma and myeloma patients. Even if the quantity of CD34+ cells collected in elderly patients was lower than in younger patients, this quantity does not reach significant difference.
Session topic: 23. Stem cell transplantation - Clinical
Keyword(s): Age, lymphoma, Myeloma, Stem cell mobilization