Contributions
Abstract: PB2442
Type: Publication Only
Background
Non-effective medical therapy is like a “worldwide problem of striking magnitude”. Sometimes ineffective medical therapy closely relates with non-compliance with medical recommendations. First 3-4 months after allogeneic stem cell transplantation (allo-HSCT) are crucial for acute graft versus host disease (GVHD) developing in patients after allo-HSCT. Here we report the data about an impact of patient non-compliance on aGVHD incidence after allo-HSCT.
Aims
to assess the impact of patient non-compliance with medical recommendations on aGVHD incidence.
Methods
We analyzed the data of 179 patients who underwent allo-HSCT between 2009-2017 in National Research Center for Hematology. All patients had an acute leukemia (59- ALL and 120 – AML) and were in complete remission (CR) before allo-HSCT. Physician expert opinion (based on physician-patient interactions and/or clinical interview with mental health specialist) was used to assess patient non-complaince with medical recommendations. Exact Fisher’s test was used to analyze the 2 × 2 contingency tables. Kaplan–Meier analysis with log-rank test was used for aGVHD probability analysis and group comparison. A p-value less than 0.05 was considered as significant.
Results
13% patients were non-compliant with medical recommendations. The groups of compliant and non-compliant patients were absolutely comparable based on various characteristics (diagnosis, sex, age, disease status, transplant source, type of donor). According to our data aGVHD occurred in “non- compliant” group more frequently than in “compliant” group - 61.7 % and 26.4 % respectively (p=0.0002). All other factors that could affect aGVHD incidence (graft source, HLA-disparity, disease status) were balanced.
Conclusion
Patient non-compliance with medical recommendations is strongly associate with developing of aGVHD. We are convinced that patient non-compliance сan reduce to zero previously conducted the best aGVHD prophylaxis. This study reinforces the importance of this problem for each transplant center and needs to be continued together with clinical psychologists and psychiatrists.
Session topic: 23. Stem cell transplantation - Clinical
Keyword(s): acute leukemia, Allo-SCT, Graft-versus-host disease (GVHD)
Abstract: PB2442
Type: Publication Only
Background
Non-effective medical therapy is like a “worldwide problem of striking magnitude”. Sometimes ineffective medical therapy closely relates with non-compliance with medical recommendations. First 3-4 months after allogeneic stem cell transplantation (allo-HSCT) are crucial for acute graft versus host disease (GVHD) developing in patients after allo-HSCT. Here we report the data about an impact of patient non-compliance on aGVHD incidence after allo-HSCT.
Aims
to assess the impact of patient non-compliance with medical recommendations on aGVHD incidence.
Methods
We analyzed the data of 179 patients who underwent allo-HSCT between 2009-2017 in National Research Center for Hematology. All patients had an acute leukemia (59- ALL and 120 – AML) and were in complete remission (CR) before allo-HSCT. Physician expert opinion (based on physician-patient interactions and/or clinical interview with mental health specialist) was used to assess patient non-complaince with medical recommendations. Exact Fisher’s test was used to analyze the 2 × 2 contingency tables. Kaplan–Meier analysis with log-rank test was used for aGVHD probability analysis and group comparison. A p-value less than 0.05 was considered as significant.
Results
13% patients were non-compliant with medical recommendations. The groups of compliant and non-compliant patients were absolutely comparable based on various characteristics (diagnosis, sex, age, disease status, transplant source, type of donor). According to our data aGVHD occurred in “non- compliant” group more frequently than in “compliant” group - 61.7 % and 26.4 % respectively (p=0.0002). All other factors that could affect aGVHD incidence (graft source, HLA-disparity, disease status) were balanced.
Conclusion
Patient non-compliance with medical recommendations is strongly associate with developing of aGVHD. We are convinced that patient non-compliance сan reduce to zero previously conducted the best aGVHD prophylaxis. This study reinforces the importance of this problem for each transplant center and needs to be continued together with clinical psychologists and psychiatrists.
Session topic: 23. Stem cell transplantation - Clinical
Keyword(s): acute leukemia, Allo-SCT, Graft-versus-host disease (GVHD)