Contributions
Abstract: PB2453
Type: Publication Only
Background
CMV infection represents one of the main cause mortality after SCT. Recently, a protective effect of the T allele of rs12979860 IL-28B SNP against CMV infection in the allogenic stem cell transplantation was suggested. We investigate whether the rs12979860 and rs368234815 (IFNl4) SNPs might affect the incidence of active CMV infection in Autologous stem cell transplantation (Auto-SCT) setting.CMV infection represents one of the main cause mortality after SCT. Recently, a protective effect of the T allele of rs12979860 IL-28B SNP against CMV infection in the allogenic stem cell transplantation was suggested.
Aims
We investigate whether the rs12979860 and rs368234815 (IFNl4) SNPs might affect the incidence of active CMV infection in Autologous stem cell transplantation (Auto-SCT) setting.
Methods
The study included 99 patients who underwent to Auto-SCT. IL28 and IFNl4 SNPs were correlated with CMV reactivation along with other clinical and treatment parameters. CMV reactivation by CMV DNAemia was evaluated once a week until day 100 from Auto-SCT.
Results
CMV reactivation was documented in 50% (TT-DG/DG), 35% (CC-TT/TT) and 29.2% (CT-TT/DG) of the patients respectively. No differences in CMV copies number were recorded at reactivation between different IL28/IFNl4 genotypes. The analysis of patients older than 60 years showed a significantly higher incidence of active CMV infection in the TT-DG/DG (83%) population with respect to CC-TT/TT (21%) and CT-TT/DG (40%) patients
Conclusion
Our data suggest a negative role of TT-DG/DG genotype in the CMV reactivation in Auto-SCT. The exposure to rituximab and the pre infusion presence of anti CMV IgG also significantly influenced CMV reactivation
Session topic: 23. Stem cell transplantation - Clinical
Keyword(s): CMV infection
Abstract: PB2453
Type: Publication Only
Background
CMV infection represents one of the main cause mortality after SCT. Recently, a protective effect of the T allele of rs12979860 IL-28B SNP against CMV infection in the allogenic stem cell transplantation was suggested. We investigate whether the rs12979860 and rs368234815 (IFNl4) SNPs might affect the incidence of active CMV infection in Autologous stem cell transplantation (Auto-SCT) setting.CMV infection represents one of the main cause mortality after SCT. Recently, a protective effect of the T allele of rs12979860 IL-28B SNP against CMV infection in the allogenic stem cell transplantation was suggested.
Aims
We investigate whether the rs12979860 and rs368234815 (IFNl4) SNPs might affect the incidence of active CMV infection in Autologous stem cell transplantation (Auto-SCT) setting.
Methods
The study included 99 patients who underwent to Auto-SCT. IL28 and IFNl4 SNPs were correlated with CMV reactivation along with other clinical and treatment parameters. CMV reactivation by CMV DNAemia was evaluated once a week until day 100 from Auto-SCT.
Results
CMV reactivation was documented in 50% (TT-DG/DG), 35% (CC-TT/TT) and 29.2% (CT-TT/DG) of the patients respectively. No differences in CMV copies number were recorded at reactivation between different IL28/IFNl4 genotypes. The analysis of patients older than 60 years showed a significantly higher incidence of active CMV infection in the TT-DG/DG (83%) population with respect to CC-TT/TT (21%) and CT-TT/DG (40%) patients
Conclusion
Our data suggest a negative role of TT-DG/DG genotype in the CMV reactivation in Auto-SCT. The exposure to rituximab and the pre infusion presence of anti CMV IgG also significantly influenced CMV reactivation
Session topic: 23. Stem cell transplantation - Clinical
Keyword(s): CMV infection