Contributions
Abstract: PB1802
Type: Publication Only
Background
Diffuse large B cell lymphoma (DLBCL) is the most common lymphoma. It is a highly heterogeneous group of neoplasms and patients have a variable clinical course and prognosis.
Aims
In this work, we try to study the difference of primary tonsil DLBCLs and nodal DLBCLs.
Methods
We analyzed a cohort of 103 primary tonsil diffuse large B cell lymphomas (DLBCLs) retrieved from our pathological file from 1998 to 2015, and compared 74 nodal DLBCLs from 2012 to 2013.
Results
In those cases with available data, the primary tonsil DLBCLs were more common confined to stage I–II disease (71%, 65/92 vs 33%, 24/73, P<0.001), and more often revealed a germinal center B-cell-like (GCB) immunophenotype (56%, 15/27 vs 29%, 17/59, P=0.029). The 5-year overall survival (OS) of primary tonsil and nodal DLBCL patients were 72% vs 58.9%(P=0.008).
Conclusion
Primary tonsil DLBCLs display distinct clinicopathologic features compared with nodal DLBCLs in Taiwan, with usual localized-stage disease, common GCB immunophenotype, and a better outcome.
Session topic: 21. Aggressive Non-Hodgkin lymphoma - Clinical
Keyword(s): Diffuse large B cell lymphoma
Abstract: PB1802
Type: Publication Only
Background
Diffuse large B cell lymphoma (DLBCL) is the most common lymphoma. It is a highly heterogeneous group of neoplasms and patients have a variable clinical course and prognosis.
Aims
In this work, we try to study the difference of primary tonsil DLBCLs and nodal DLBCLs.
Methods
We analyzed a cohort of 103 primary tonsil diffuse large B cell lymphomas (DLBCLs) retrieved from our pathological file from 1998 to 2015, and compared 74 nodal DLBCLs from 2012 to 2013.
Results
In those cases with available data, the primary tonsil DLBCLs were more common confined to stage I–II disease (71%, 65/92 vs 33%, 24/73, P<0.001), and more often revealed a germinal center B-cell-like (GCB) immunophenotype (56%, 15/27 vs 29%, 17/59, P=0.029). The 5-year overall survival (OS) of primary tonsil and nodal DLBCL patients were 72% vs 58.9%(P=0.008).
Conclusion
Primary tonsil DLBCLs display distinct clinicopathologic features compared with nodal DLBCLs in Taiwan, with usual localized-stage disease, common GCB immunophenotype, and a better outcome.
Session topic: 21. Aggressive Non-Hodgkin lymphoma - Clinical
Keyword(s): Diffuse large B cell lymphoma