Contributions
Abstract: PB2039
Type: Publication Only
Background
Gastric MALT lymphoma is one of low grade B lymphoma that can be cured in many cases by antibiotics targeting HP infection
Aims
We report a study of 35 patients diagnosed and treated for Gastric MALT lymphoma.
Methods
This study concern all patients followed for Gastric MALT lymphoma between 2001 and 2016 at Sfax Hedi Chaker Hospital in the south of Tunisia. Upper endoscopy was performed for all patients, multiple biopsies served to Histo-pathologic analysis and HP detection. Physical examination, LDH dosage, echo-endoscopy, chest and abdominal scan and bone marrow biopsy were performed to Musshoff (Ann-Arbor modified) staging of lymphoma.First line treatment consists on HP eradication therapy (patrician choice: three therapy, sequential therapy or quadri-therapy Bismuth) . A double endoscopic control was performed initially to verify HP eradication, and secondary to evaluate lymphoma response according to the GELA-Lysa criteria.Stomach Radiotherapy was proposed for HP negative localized lymphoma, HP resistant to two different eradication schemas or no responded lymphoma.
Results
A total of 35 patients had Gastric MALT lymphoma. Median of age was 51 years. Sex ratio=0.94. Pseudo-gastritis, ulcers, and pseudo-tumoral aspects were found in respectively 40%, 35% and 25%. HP was found in 32 patients (91%). Lymphoma had localized stage in all patients (stage IE= 80%, stage IIE=20%). 32 HP positive and 2 HP negative patients received first line eradication therapy. Eradication was obtained in 68% of cases and in all HP positive cases (100%) after two switched schemas. According to GELA-Lysa criteria: complete response was obtained in 27 cases (CR=25, pMRD=2), partial response in three cases, AND no change response in four cases. Five patients (2HP negative and 3 HP positive) underwent Radiotherapy achieving a CR.
During follow up, no patient have lymphoma relapse, two cases with NC response showed a progression to diffuse B large cell lymphoma
Conclusion
In our region, Gastric MALT lymphoma is frequently associated to HP (more than 90%) and presenting in localized stage. Eradication schemas therapy leads to the disappearance of HP in 100% of cases and regression of lymphoma in 80% of cases even in HP negative patients. Radiotherapy stills a second arm for non responded patients.
Session topic: 20. Indolent Non-Hodgkin lymphoma – Clinical
Keyword(s): Helicobacter pylori, MALT lymphoma
Abstract: PB2039
Type: Publication Only
Background
Gastric MALT lymphoma is one of low grade B lymphoma that can be cured in many cases by antibiotics targeting HP infection
Aims
We report a study of 35 patients diagnosed and treated for Gastric MALT lymphoma.
Methods
This study concern all patients followed for Gastric MALT lymphoma between 2001 and 2016 at Sfax Hedi Chaker Hospital in the south of Tunisia. Upper endoscopy was performed for all patients, multiple biopsies served to Histo-pathologic analysis and HP detection. Physical examination, LDH dosage, echo-endoscopy, chest and abdominal scan and bone marrow biopsy were performed to Musshoff (Ann-Arbor modified) staging of lymphoma.First line treatment consists on HP eradication therapy (patrician choice: three therapy, sequential therapy or quadri-therapy Bismuth) . A double endoscopic control was performed initially to verify HP eradication, and secondary to evaluate lymphoma response according to the GELA-Lysa criteria.Stomach Radiotherapy was proposed for HP negative localized lymphoma, HP resistant to two different eradication schemas or no responded lymphoma.
Results
A total of 35 patients had Gastric MALT lymphoma. Median of age was 51 years. Sex ratio=0.94. Pseudo-gastritis, ulcers, and pseudo-tumoral aspects were found in respectively 40%, 35% and 25%. HP was found in 32 patients (91%). Lymphoma had localized stage in all patients (stage IE= 80%, stage IIE=20%). 32 HP positive and 2 HP negative patients received first line eradication therapy. Eradication was obtained in 68% of cases and in all HP positive cases (100%) after two switched schemas. According to GELA-Lysa criteria: complete response was obtained in 27 cases (CR=25, pMRD=2), partial response in three cases, AND no change response in four cases. Five patients (2HP negative and 3 HP positive) underwent Radiotherapy achieving a CR.
During follow up, no patient have lymphoma relapse, two cases with NC response showed a progression to diffuse B large cell lymphoma
Conclusion
In our region, Gastric MALT lymphoma is frequently associated to HP (more than 90%) and presenting in localized stage. Eradication schemas therapy leads to the disappearance of HP in 100% of cases and regression of lymphoma in 80% of cases even in HP negative patients. Radiotherapy stills a second arm for non responded patients.
Session topic: 20. Indolent Non-Hodgkin lymphoma – Clinical
Keyword(s): Helicobacter pylori, MALT lymphoma