Contributions
Abstract: PB2000
Type: Publication Only
Background
Although ‘interim’ positron emission tomography (PET) may inform therapeutic decisions, Risk stratification at diagnosis could may allow earlier and potentially more efficacious treatment modification during treatment of HL.
Aims
In this study we aimed to identify the prognostic role of both the IPET and the CHIPS in predicting the prognosis of HL in our center
Methods
This is a retrospective, single center study where a total of 140 patients with newly diagnosed Hodgkin lymphoma were enrolled. Only 83 patients were eligible for analysis of both IPET and CHIPS scoring. PET scan was performed at baseline and after two cycles of chemotherapy. Treatment was not changed according to the results of the interim scan. PET scans reports was used using the Deauville five-point scale, blinded to treatment outcome. Childhood Hodgkin International Prognostic Score (CHIPS),was evaluated [included age (<13), number of involved sites (<3), hemoglobin (<10.5), albumin (<3.5), and erythrocyte sedimentation rate (ESR) (<20). ESR <50 ].Log rank testing was used to compare EFS for each CHIPS (0–3)
Results
Eighty-three scans out of 140 patients were eligible for analysis of both IPET and CHIPS scoring. Twenty six patients were scored positive (31.3%) and 57 (68.7%) as negative. The 5- years overall survival (OS) was 94%, 83% for patients with interim positive scans and 97% for patients with interim negative scans (P<0.01). The 5-year Event-free survival (EFS) rate was 86.7% for the whole study population, 76% for patients with interim positive scans and 91% for patients with interim negative scans (P<0.04). Stage 4 disease, large mediastinal mass, albumin (<3.5), and fever were independent predictors of EFS that were each assigned one point in the CHIPS. 3-year EFS was 95.7% for patients with CHIPS = 0, 84.2% for patients with CHIPS = 1, 75% for patients with CHIPS = 2, and 80% for patients with CHIPS = 3 ( mostly due to a very limited number of patients) .
Conclusion
The prognostic role and validity of using the interim PET scan response have been confirmed to be strongly related to treatment outcome by the present study. However the use of CHIPS scoring CHIPS is a good inexpensive approach to predicting risk in patients with HL that may improve ability to tailor therapy to risk factors known at diagnosis.
Session topic: 17. Hodgkin lymphoma – Clinical
Keyword(s): Childhood, Hodgkin's Lymphoma, PET, Prognostic factor
Abstract: PB2000
Type: Publication Only
Background
Although ‘interim’ positron emission tomography (PET) may inform therapeutic decisions, Risk stratification at diagnosis could may allow earlier and potentially more efficacious treatment modification during treatment of HL.
Aims
In this study we aimed to identify the prognostic role of both the IPET and the CHIPS in predicting the prognosis of HL in our center
Methods
This is a retrospective, single center study where a total of 140 patients with newly diagnosed Hodgkin lymphoma were enrolled. Only 83 patients were eligible for analysis of both IPET and CHIPS scoring. PET scan was performed at baseline and after two cycles of chemotherapy. Treatment was not changed according to the results of the interim scan. PET scans reports was used using the Deauville five-point scale, blinded to treatment outcome. Childhood Hodgkin International Prognostic Score (CHIPS),was evaluated [included age (<13), number of involved sites (<3), hemoglobin (<10.5), albumin (<3.5), and erythrocyte sedimentation rate (ESR) (<20). ESR <50 ].Log rank testing was used to compare EFS for each CHIPS (0–3)
Results
Eighty-three scans out of 140 patients were eligible for analysis of both IPET and CHIPS scoring. Twenty six patients were scored positive (31.3%) and 57 (68.7%) as negative. The 5- years overall survival (OS) was 94%, 83% for patients with interim positive scans and 97% for patients with interim negative scans (P<0.01). The 5-year Event-free survival (EFS) rate was 86.7% for the whole study population, 76% for patients with interim positive scans and 91% for patients with interim negative scans (P<0.04). Stage 4 disease, large mediastinal mass, albumin (<3.5), and fever were independent predictors of EFS that were each assigned one point in the CHIPS. 3-year EFS was 95.7% for patients with CHIPS = 0, 84.2% for patients with CHIPS = 1, 75% for patients with CHIPS = 2, and 80% for patients with CHIPS = 3 ( mostly due to a very limited number of patients) .
Conclusion
The prognostic role and validity of using the interim PET scan response have been confirmed to be strongly related to treatment outcome by the present study. However the use of CHIPS scoring CHIPS is a good inexpensive approach to predicting risk in patients with HL that may improve ability to tailor therapy to risk factors known at diagnosis.
Session topic: 17. Hodgkin lymphoma – Clinical
Keyword(s): Childhood, Hodgkin's Lymphoma, PET, Prognostic factor