Contributions
Abstract: PB2273
Type: Publication Only
Background
Elevated platelet count is characteristic features observed in myeloproliferative disorders, such as Polycythemia vera (PV) and Essential thrombocythemia (ET) but also could be observed in other reactive conditions. Several studies reported elevated numbers of immature platelet population in PV and ET compared to the normal control and yet studies comparing the patients with reactive thrombocytosis have not been performed.
Aims
In this study, we analyzed platelet related parameters including immature platelet fraction (IPF) for prediction of PV and ET in patients with thrombocytosis.
Methods
A retrospective study of IPF, immature platelet count (platelet count x IPF) and other platelet related parameters, such as plateletcrit (PCT), mean platelet volume (MPV) and platelet distribution width (PDW) were conducted using hematology analyzer XE-5000 (Sysmex, Kobe, Japan). A total of 100 whole blood samples from patients with thrombocytosis (platelet count ≥450x109/L) were included and among these, 11 were from PV, 13 from ET and 76 were from reactive thrombocytosis.
Results
IPF and immature platelet count were significantly higher in both PV and ET groups compared to the reactive thrombocytosis group. Moreover, PCT, PDW and MPV were also significantly elevated in both groups. Using ROC curve analysis, immature platelet count and PDW showed highest area under curve (both 0.86). In case of immature platelet count and PDW, with cut-off level of 10,243/μL and 10.75 fL, the sensitivities were 91.7% and 83.3%, respectively and specificities were 66.7% and 76.9%, respectively.
Conclusion
Identification of patients with possibility of PV and ET among the patients with thrombocytosis would allow prompt work up and appropriate treatment. Among the platelet associated parameter, immature platelet count and PDW were the most valuable in discriminating PV and ET from reactive thrombocytosis and would be useful for the differential diagnosis of patients with thrombocytosis.
Session topic: 16. Myeloproliferative neoplasms - Clinical
Keyword(s): Essential Thrombocytemia, Platelet, Polycythemia vera
Abstract: PB2273
Type: Publication Only
Background
Elevated platelet count is characteristic features observed in myeloproliferative disorders, such as Polycythemia vera (PV) and Essential thrombocythemia (ET) but also could be observed in other reactive conditions. Several studies reported elevated numbers of immature platelet population in PV and ET compared to the normal control and yet studies comparing the patients with reactive thrombocytosis have not been performed.
Aims
In this study, we analyzed platelet related parameters including immature platelet fraction (IPF) for prediction of PV and ET in patients with thrombocytosis.
Methods
A retrospective study of IPF, immature platelet count (platelet count x IPF) and other platelet related parameters, such as plateletcrit (PCT), mean platelet volume (MPV) and platelet distribution width (PDW) were conducted using hematology analyzer XE-5000 (Sysmex, Kobe, Japan). A total of 100 whole blood samples from patients with thrombocytosis (platelet count ≥450x109/L) were included and among these, 11 were from PV, 13 from ET and 76 were from reactive thrombocytosis.
Results
IPF and immature platelet count were significantly higher in both PV and ET groups compared to the reactive thrombocytosis group. Moreover, PCT, PDW and MPV were also significantly elevated in both groups. Using ROC curve analysis, immature platelet count and PDW showed highest area under curve (both 0.86). In case of immature platelet count and PDW, with cut-off level of 10,243/μL and 10.75 fL, the sensitivities were 91.7% and 83.3%, respectively and specificities were 66.7% and 76.9%, respectively.
Conclusion
Identification of patients with possibility of PV and ET among the patients with thrombocytosis would allow prompt work up and appropriate treatment. Among the platelet associated parameter, immature platelet count and PDW were the most valuable in discriminating PV and ET from reactive thrombocytosis and would be useful for the differential diagnosis of patients with thrombocytosis.
Session topic: 16. Myeloproliferative neoplasms - Clinical
Keyword(s): Essential Thrombocytemia, Platelet, Polycythemia vera