Contributions
Abstract: PB2245
Type: Publication Only
Background
Traditionally, Multiple Myeloma (MM) has been considered a disease of the elderly with peak incidence at 60-70 years of age. However, there exists a certain subset of extremely young patients. Data on young adults with MM is scarce. We present the disease characteristics for this unique age group.
Aims
1. To understand the frequency of patients with young myeloma (<=40 years), their clinical profile and response to therapy.
2. To compare with older population in terms of clinical profile.
Methods
Retrospective single-centre study conducted at a single tertiary care centre from New Delhi, North India. Records of all young patients (18-40 years) with MM managed in our department in the last 6 years (January 2012 – December 2017) were reviewed.
Results
A total of 112 evaluable patients were included in the study. Interestingly, the frequency of young MM patients was 27.6% (31/112), 3 of whom were less than 30 years of age at diagnosis. Unlike elderly, females almost equated the males in this age group (male:female : 1.06:1). Main presenting manifestations were back pain (64.5%), fatigue (58%) and referral for renal dysfunction (19.3%). Other presenting features included plasmacytomas (13%), weight loss (6%), bleeding manifestations (3%) and cord compression (3%). Hypercalcemia, renal dysfunction, anemia and lytic lesions were present in 19.3%, 35.4%, 71% and 77.4% patients respectively. Of these, one-fourth patients (25.8%) underwent autologous stem-cell transplant. Baseline beta-2-microglobulin levels were available in 23 patients. 82.6% patients were in high risk group as per ISS – 3 (International Staging System) staging. Almost one-third cases (n=10) (32.2%) were relapsed-refractory. FISH panel was done in 8 patients, 2 (25%) of whom revealed 13q deletion.
Conclusion
Our study shows a trend towards gender equality in young patients with MM, a higher prevalence of high-risk (ISS-3) disease, higher prevalence of appendicular skeleton lesions and good response to therapy.
Session topic: 14. Myeloma and other monoclonal gammopathies - Clinical
Keyword(s): Multiple Myeloma, Young adult
Abstract: PB2245
Type: Publication Only
Background
Traditionally, Multiple Myeloma (MM) has been considered a disease of the elderly with peak incidence at 60-70 years of age. However, there exists a certain subset of extremely young patients. Data on young adults with MM is scarce. We present the disease characteristics for this unique age group.
Aims
1. To understand the frequency of patients with young myeloma (<=40 years), their clinical profile and response to therapy.
2. To compare with older population in terms of clinical profile.
Methods
Retrospective single-centre study conducted at a single tertiary care centre from New Delhi, North India. Records of all young patients (18-40 years) with MM managed in our department in the last 6 years (January 2012 – December 2017) were reviewed.
Results
A total of 112 evaluable patients were included in the study. Interestingly, the frequency of young MM patients was 27.6% (31/112), 3 of whom were less than 30 years of age at diagnosis. Unlike elderly, females almost equated the males in this age group (male:female : 1.06:1). Main presenting manifestations were back pain (64.5%), fatigue (58%) and referral for renal dysfunction (19.3%). Other presenting features included plasmacytomas (13%), weight loss (6%), bleeding manifestations (3%) and cord compression (3%). Hypercalcemia, renal dysfunction, anemia and lytic lesions were present in 19.3%, 35.4%, 71% and 77.4% patients respectively. Of these, one-fourth patients (25.8%) underwent autologous stem-cell transplant. Baseline beta-2-microglobulin levels were available in 23 patients. 82.6% patients were in high risk group as per ISS – 3 (International Staging System) staging. Almost one-third cases (n=10) (32.2%) were relapsed-refractory. FISH panel was done in 8 patients, 2 (25%) of whom revealed 13q deletion.
Conclusion
Our study shows a trend towards gender equality in young patients with MM, a higher prevalence of high-risk (ISS-3) disease, higher prevalence of appendicular skeleton lesions and good response to therapy.
Session topic: 14. Myeloma and other monoclonal gammopathies - Clinical
Keyword(s): Multiple Myeloma, Young adult