Contributions
Abstract: PB2131
Type: Publication Only
Background
Monoclonal gammopathy of undetermined significance (MGUS) is a premalignant, clonal plasma cell disorder, characterized by the presence of a monoclonal (M) protein, <10% clonal plasma cells in the bone marrow, and absence of multiple myeloma or related lymphoplasmacytic malignancies. MGUS is present in 3% of the general population ≥50 years old. Dendritic cells (DCs) are a heterogeneous population of leukocytes defined as professional antigen presenting cells playing a key role in anticancer immunity.
Aims
The purpose of this study was to evaluate subpopulations of myeloid and lymphoid DCs in the peripheral blood (PB) and bone marrow (BM) of patients with MGUS in correlation with known prognostic factors.
Methods
The study involved 40 patients diagnosed with MGUS and 20 individuals belonging to the control group. The mean percentage of myeloid and lymphoid DCs was determined using flow cytometry.
Results
In the present study, we demonstrated a significant reduction in the percentages of both myeloid and lymphoid DCs in MGUS patients, more pronounced in those with the worse prognosis as determined by the high levels of M protein and low concentration of hemoglobin. Accordingly, a marked decrease in the proportions of both myeloid and lymphoid DCs in the BM of patients with MGUS in comparison with healthy controls was also found. The frequencies of both myeloid and lymphoid DCs correlated negatively with the percentages of plasmocytes in the BM.
Conclusion
Our results suggest that the degree of DC subpopulations deficit could be related to the MGUS progression, which in consequence may contribute to the MGUS-related impairment of the immune responses.
This work was supported by research grants no. DS460 of the Medical University of Lublin and no. UMO-2016/21/B/NZ6/02279 of the Polish National Science Centre.
Session topic: 13. Myeloma and other monoclonal gammopathies – Biology & Translational Research
Keyword(s): Bone Marrow, Dendritic cell, Monoclonal gammopathy, Peripheral blood
Abstract: PB2131
Type: Publication Only
Background
Monoclonal gammopathy of undetermined significance (MGUS) is a premalignant, clonal plasma cell disorder, characterized by the presence of a monoclonal (M) protein, <10% clonal plasma cells in the bone marrow, and absence of multiple myeloma or related lymphoplasmacytic malignancies. MGUS is present in 3% of the general population ≥50 years old. Dendritic cells (DCs) are a heterogeneous population of leukocytes defined as professional antigen presenting cells playing a key role in anticancer immunity.
Aims
The purpose of this study was to evaluate subpopulations of myeloid and lymphoid DCs in the peripheral blood (PB) and bone marrow (BM) of patients with MGUS in correlation with known prognostic factors.
Methods
The study involved 40 patients diagnosed with MGUS and 20 individuals belonging to the control group. The mean percentage of myeloid and lymphoid DCs was determined using flow cytometry.
Results
In the present study, we demonstrated a significant reduction in the percentages of both myeloid and lymphoid DCs in MGUS patients, more pronounced in those with the worse prognosis as determined by the high levels of M protein and low concentration of hemoglobin. Accordingly, a marked decrease in the proportions of both myeloid and lymphoid DCs in the BM of patients with MGUS in comparison with healthy controls was also found. The frequencies of both myeloid and lymphoid DCs correlated negatively with the percentages of plasmocytes in the BM.
Conclusion
Our results suggest that the degree of DC subpopulations deficit could be related to the MGUS progression, which in consequence may contribute to the MGUS-related impairment of the immune responses.
This work was supported by research grants no. DS460 of the Medical University of Lublin and no. UMO-2016/21/B/NZ6/02279 of the Polish National Science Centre.
Session topic: 13. Myeloma and other monoclonal gammopathies – Biology & Translational Research
Keyword(s): Bone Marrow, Dendritic cell, Monoclonal gammopathy, Peripheral blood