Contributions
Abstract: PB1837
Type: Publication Only
Background
the collagen vascular diseases area diverse group of inflammatory systemic disorders thought to be immunologically mediatedincluding systemic lupus erythematosus (SLE), scleroderma, polymyositis and polyarteritisnodosa, they are frequently included in the differential diagnosis for unexplained cytopenias and often prompt a bone marrow evaluation in this population is important.
Aims
to study morphologic and immunohistochemical characteristics of bone marrow involvement in patients with collagen vascular diseases associated with cytopenias
Methods
In the current study, we examined 100 patients. The diagnosis of collagen vascular diseases was made according to diagnostic criteria for each as SLICC for SLE.All patients were subjected to thorough history taking, physical examination, and many investigations were done for them including serology (ANA, Anti dsDNA, AntiCCP, RF), and bone marrow examination was done for all patients.
Results
collagen vascular diseases show female predominance regarding SLE and RA with male: female ratio equal 3:14 and 1:4 respectively. Nephritis and arthritis were the most common presentation in SLE and RA respectively and almost present in all patients followed by hematological manifestations as fatigue and ecchymosis. Normocellular bone marrow was the commonest finding in studied patients followed by hypercellular marrow then hypocellular marrow while dysplastic changes affected erythroid element mostly followed by myloid and megakaryocytic elements regarding eosinipgilic, plasma cells and lymphocytic infiltrations; none of them shows statistically significance
Conclusion
There were no significant statistical differences between CVDs patients as regard bone marrow findingalso there were no specific bone marrow finding detected in SLE and RA patients.
Session topic: 12. Bone marrow failure syndromes incl. PNH - Clinical
Keyword(s): Bone marrow involvement, Systemic lupus erythematosus
Abstract: PB1837
Type: Publication Only
Background
the collagen vascular diseases area diverse group of inflammatory systemic disorders thought to be immunologically mediatedincluding systemic lupus erythematosus (SLE), scleroderma, polymyositis and polyarteritisnodosa, they are frequently included in the differential diagnosis for unexplained cytopenias and often prompt a bone marrow evaluation in this population is important.
Aims
to study morphologic and immunohistochemical characteristics of bone marrow involvement in patients with collagen vascular diseases associated with cytopenias
Methods
In the current study, we examined 100 patients. The diagnosis of collagen vascular diseases was made according to diagnostic criteria for each as SLICC for SLE.All patients were subjected to thorough history taking, physical examination, and many investigations were done for them including serology (ANA, Anti dsDNA, AntiCCP, RF), and bone marrow examination was done for all patients.
Results
collagen vascular diseases show female predominance regarding SLE and RA with male: female ratio equal 3:14 and 1:4 respectively. Nephritis and arthritis were the most common presentation in SLE and RA respectively and almost present in all patients followed by hematological manifestations as fatigue and ecchymosis. Normocellular bone marrow was the commonest finding in studied patients followed by hypercellular marrow then hypocellular marrow while dysplastic changes affected erythroid element mostly followed by myloid and megakaryocytic elements regarding eosinipgilic, plasma cells and lymphocytic infiltrations; none of them shows statistically significance
Conclusion
There were no significant statistical differences between CVDs patients as regard bone marrow findingalso there were no specific bone marrow finding detected in SLE and RA patients.
Session topic: 12. Bone marrow failure syndromes incl. PNH - Clinical
Keyword(s): Bone marrow involvement, Systemic lupus erythematosus