Contributions
Abstract: PB2111
Type: Publication Only
Background
Inflammatory and immune response in tumor microenvironment is important in the pathophysiology of tumor progression, and has been studied so far in many solid tumors and haematological malignancies. In tumor microenvironment, neutrophils secrete different cytokines that stimulate tumor growth, while lymphocytes represent immune defense against tumor cells and mediate cytotoxic cell death . Absolute neutrophil to lymphocyte ratio (NLR) was previously analyzed as prognostic parameter in solid tumors and haematological disorders. Thrombocytopenia is a known hematologic parameter of poor survival in patients with myelodysplastic syndrome (MDS). In this work, we tried to determine the prognostic significance of NLR and platelet count in MDS patient group.
Aims
In the retrospective cohort of 58 untreated MDS patients, we analyzed clinical and laboratory data of MDS patients and the prognostic significance of the NLR and platelet count in correlation with well known prognostic indices (IPSS, IPSSR).
Methods
The study included 58 patients (24 women, 34 males), median age 73 years. Patients with IPSS <1.5 had significantly higher platelet count compared to those with IPSS> 1.5 (138 vs. 58, p <0.001), as well as in the R-IPSS group <4.5 versus those in the group with R-IPSS> 4.5 (122 vs. 68, p <0.01).
Results
No statistically significant difference in NLR (p <0.087 for IPSS or p <0.112 for R-IPSS) was found. The number of platelets showed a negative correlation with IPSS (rho = -0.500, p <0.001) and R-IPSS (rho = -0.456, p <0.001). Analyzing other parameters, statistically significant correlation of IPSS with LDH (p <0.008) and CRP (p <0.01) was observed. In the IPSS group <1.5 there was a significantly lower LDH level compared to patients with IPSS> 1.5 (189 vs. 233) as well as for CRP (3.25 vs. 11.05) The same observation was for R-IPSS (for LDH 189.5 vs. 227.5, p <0.01, for CRP 2.55 vs 12.1, p <0.002).
Conclusion
In a small number of our patients, we have shown that platelet count, LDH and CRP, have negative correlation with IPSS and R-IPSS prognostic index. NLR was not statistically significant, but this should be analyzed on a larger number of MDS patients.
Session topic: 10. Myelodysplastic syndromes – Clinical
Abstract: PB2111
Type: Publication Only
Background
Inflammatory and immune response in tumor microenvironment is important in the pathophysiology of tumor progression, and has been studied so far in many solid tumors and haematological malignancies. In tumor microenvironment, neutrophils secrete different cytokines that stimulate tumor growth, while lymphocytes represent immune defense against tumor cells and mediate cytotoxic cell death . Absolute neutrophil to lymphocyte ratio (NLR) was previously analyzed as prognostic parameter in solid tumors and haematological disorders. Thrombocytopenia is a known hematologic parameter of poor survival in patients with myelodysplastic syndrome (MDS). In this work, we tried to determine the prognostic significance of NLR and platelet count in MDS patient group.
Aims
In the retrospective cohort of 58 untreated MDS patients, we analyzed clinical and laboratory data of MDS patients and the prognostic significance of the NLR and platelet count in correlation with well known prognostic indices (IPSS, IPSSR).
Methods
The study included 58 patients (24 women, 34 males), median age 73 years. Patients with IPSS <1.5 had significantly higher platelet count compared to those with IPSS> 1.5 (138 vs. 58, p <0.001), as well as in the R-IPSS group <4.5 versus those in the group with R-IPSS> 4.5 (122 vs. 68, p <0.01).
Results
No statistically significant difference in NLR (p <0.087 for IPSS or p <0.112 for R-IPSS) was found. The number of platelets showed a negative correlation with IPSS (rho = -0.500, p <0.001) and R-IPSS (rho = -0.456, p <0.001). Analyzing other parameters, statistically significant correlation of IPSS with LDH (p <0.008) and CRP (p <0.01) was observed. In the IPSS group <1.5 there was a significantly lower LDH level compared to patients with IPSS> 1.5 (189 vs. 233) as well as for CRP (3.25 vs. 11.05) The same observation was for R-IPSS (for LDH 189.5 vs. 227.5, p <0.01, for CRP 2.55 vs 12.1, p <0.002).
Conclusion
In a small number of our patients, we have shown that platelet count, LDH and CRP, have negative correlation with IPSS and R-IPSS prognostic index. NLR was not statistically significant, but this should be analyzed on a larger number of MDS patients.
Session topic: 10. Myelodysplastic syndromes – Clinical