Contributions
Abstract: PB1644
Type: Publication Only
Background
Acute lymphoblastic leukemia (ALL) occupies a leading position in the structure of childhood cancer.The use of long-term multimodal therapy allowed achieving high survival rates. However, 15-20% of patients have got the relapses of the disease, which are the cause of failure of treatment of children with ALL.
Aims
To study the frequency of development of relapses of acute lymphoblastic leukemia in children on programmed therapy.
Methods
247 patients with newly diagnosed ALL were monitored in the children's hematology department in the period from 1991 to 2017. 36 (15,4%) of children at different stages of observation have relapses. The age of patients ranged from 2 till 18 years (median 8,0 years).
Results
In the first acute period 20 (55,5%) patients were treated with protocol ALL-BFM-90; ALL-MB-2002. ALL-MB-2008. ALL-MB-2015 - 16 (44,4%). The structure of recurrences was as follows: isolated bone marrow relapse-27 cases, the combined - 4, isolated ekstramedullar - 12 (33,3%) of the relapses classified as very early, 16 (44,4%) early and 8 (22,2%) late. Antireccurence therapy was conducted in 34 patients, the two did not receive treatment due to refusal of parents. Refractory to therapy was recorded in 6 patients, 4 patients died of various complications and progression of the disease before reaching remission.The second complete remission was obtained in 70% of cases (24 patients). Transplantation of hematopoietic stem cells from an related donor carried in 1 patient, ended lethally,1 patient died of various complications during remission, 9 - developed a second relapse (3 patients are alive in one-third complete remission).16 (44%) patients are in long remission.
Conclusion
The frequency of relapses in patients of ALL was 15,4%(36). 44% patients are in long remission.
Session topic: 2. Acute lymphoblastic leukemia - Clinical
Keyword(s): chemotherapy, Children, Relapsed acute lymphoblastic leukemia
Abstract: PB1644
Type: Publication Only
Background
Acute lymphoblastic leukemia (ALL) occupies a leading position in the structure of childhood cancer.The use of long-term multimodal therapy allowed achieving high survival rates. However, 15-20% of patients have got the relapses of the disease, which are the cause of failure of treatment of children with ALL.
Aims
To study the frequency of development of relapses of acute lymphoblastic leukemia in children on programmed therapy.
Methods
247 patients with newly diagnosed ALL were monitored in the children's hematology department in the period from 1991 to 2017. 36 (15,4%) of children at different stages of observation have relapses. The age of patients ranged from 2 till 18 years (median 8,0 years).
Results
In the first acute period 20 (55,5%) patients were treated with protocol ALL-BFM-90; ALL-MB-2002. ALL-MB-2008. ALL-MB-2015 - 16 (44,4%). The structure of recurrences was as follows: isolated bone marrow relapse-27 cases, the combined - 4, isolated ekstramedullar - 12 (33,3%) of the relapses classified as very early, 16 (44,4%) early and 8 (22,2%) late. Antireccurence therapy was conducted in 34 patients, the two did not receive treatment due to refusal of parents. Refractory to therapy was recorded in 6 patients, 4 patients died of various complications and progression of the disease before reaching remission.The second complete remission was obtained in 70% of cases (24 patients). Transplantation of hematopoietic stem cells from an related donor carried in 1 patient, ended lethally,1 patient died of various complications during remission, 9 - developed a second relapse (3 patients are alive in one-third complete remission).16 (44%) patients are in long remission.
Conclusion
The frequency of relapses in patients of ALL was 15,4%(36). 44% patients are in long remission.
Session topic: 2. Acute lymphoblastic leukemia - Clinical
Keyword(s): chemotherapy, Children, Relapsed acute lymphoblastic leukemia