Contributions
Abstract: PB1648
Type: Publication Only
Background
Precursor B and T cell lymphoid malignancies represent heterogeneous disorders in terms of natural course and outcome especially when comparing pediatric and adult populations, such variation reflects the different biology between these age subtypes. The definition of adolescents and young adults (AYA) is itself controversial and varies in trials .It can be up to age of 40 or even 50. AYA patients with acute lymphoblastic leukemia (ALL) have outcomes that are historically inferior to those of children largely due to the increase frequency of adverse genetic alterations in adults; like the higher frequency of Philadelphia chromosome-positive or the recently described Philadelphia like ALL.
Aims
To report the clinical and prognestic factors of AYA patients diagnosed with precursor lymphoid malignancy in Qatar and establish the age cutoff at which adverse clinical and biological findings are observed.
Methods
This is a retrospective study in the National Centre for Cancer Care and Research which is the only cancer care provider for adults in Qatar. Patients diagnosed with B or T cell ALL or lymphoblastic lymphoma older than or equal 14 year old and who were diagnosed between January 2013 and December 2017 were included. We defined AYA as patients diagnosed at 39 year of age or younger (14-39 year old). we studied the occurence of adverse clinical and cytogenetic variables and compared them in AYA and non AYA groups. White blood cell count (WBC) cutoff at diagnosis of >100x103/mcl for T cell malignancy and >30x103/mcl for B cell subtype were considered adverse.
Results
A total of 83 patient were identified,74 males and 9 females (the significant gender variability is due to Qatar demographics were male industrial task force constitute most of the population). Median age at diagnosis was 30 (range15-71). 61 patients were in the AYA group (88% of the cohort) and 22 patients were non AYA. B cell lymphoblastic lineage contributed to 51% of ALL diagnosis in the AYA group and 48% were T cell malignancy. AYA patients with T cell lineage ALL had higher WBC at diagnosis when compared to non AYA (P=0.034).No significant difference in WBC between both groups in B cell subtype. Moreover,AYA patients had significantly lower frequency of (Ph+) ALL than non AYA.(P=0.004), other cytogenetic abnormalities were similar in both groups.
Conclusion
Our cohort identified 39 year of age as the cutoff at which prognosis differs. There was lack of favorable cytogenetics in all the cohort and predominence of (Ph+) ALL in patients 40 year old or older. Moreover AYA patients with T lymphoblastic malignancy presented with more bulky disease and higher risk features.
Session topic: 2. Acute lymphoblastic leukemia - Clinical
Keyword(s): Acute lymphoblastic leukemia, Adolescents, adult
Abstract: PB1648
Type: Publication Only
Background
Precursor B and T cell lymphoid malignancies represent heterogeneous disorders in terms of natural course and outcome especially when comparing pediatric and adult populations, such variation reflects the different biology between these age subtypes. The definition of adolescents and young adults (AYA) is itself controversial and varies in trials .It can be up to age of 40 or even 50. AYA patients with acute lymphoblastic leukemia (ALL) have outcomes that are historically inferior to those of children largely due to the increase frequency of adverse genetic alterations in adults; like the higher frequency of Philadelphia chromosome-positive or the recently described Philadelphia like ALL.
Aims
To report the clinical and prognestic factors of AYA patients diagnosed with precursor lymphoid malignancy in Qatar and establish the age cutoff at which adverse clinical and biological findings are observed.
Methods
This is a retrospective study in the National Centre for Cancer Care and Research which is the only cancer care provider for adults in Qatar. Patients diagnosed with B or T cell ALL or lymphoblastic lymphoma older than or equal 14 year old and who were diagnosed between January 2013 and December 2017 were included. We defined AYA as patients diagnosed at 39 year of age or younger (14-39 year old). we studied the occurence of adverse clinical and cytogenetic variables and compared them in AYA and non AYA groups. White blood cell count (WBC) cutoff at diagnosis of >100x103/mcl for T cell malignancy and >30x103/mcl for B cell subtype were considered adverse.
Results
A total of 83 patient were identified,74 males and 9 females (the significant gender variability is due to Qatar demographics were male industrial task force constitute most of the population). Median age at diagnosis was 30 (range15-71). 61 patients were in the AYA group (88% of the cohort) and 22 patients were non AYA. B cell lymphoblastic lineage contributed to 51% of ALL diagnosis in the AYA group and 48% were T cell malignancy. AYA patients with T cell lineage ALL had higher WBC at diagnosis when compared to non AYA (P=0.034).No significant difference in WBC between both groups in B cell subtype. Moreover,AYA patients had significantly lower frequency of (Ph+) ALL than non AYA.(P=0.004), other cytogenetic abnormalities were similar in both groups.
Conclusion
Our cohort identified 39 year of age as the cutoff at which prognosis differs. There was lack of favorable cytogenetics in all the cohort and predominence of (Ph+) ALL in patients 40 year old or older. Moreover AYA patients with T lymphoblastic malignancy presented with more bulky disease and higher risk features.
Session topic: 2. Acute lymphoblastic leukemia - Clinical
Keyword(s): Acute lymphoblastic leukemia, Adolescents, adult