Contributions
Abstract: PB2489
Type: Publication Only
Background
β thalassemia major associated nephropathy has recently been a growing matter of concern affecting most aging thalassemia major patients. Serum creatinine is alone an unreliable indicator of renal functions.
Aims
The aim of the present study is to investigate the presence of glomerular dysfunctions in adults with β thalassemia major (β-TM), using early biomarkers of glomerular dysfunctions.
Methods
50 patients with β-TM were subjected to history taking and clinical examination. Urinary albumin/creatinine ratio (ACR), Serum cystatin-C (SCys-C) levels were measured and CKD-EPI-CysC equation for estimated glomerular filtration rate (eGFR) were calculated. Presence of ACR>300mg/g and/or decreased eGFR cys were considered as glomerular dysfunction.
Results
Cases with HCV infection or diabetes were excluded from our analysis for possible risk factors for glomerular dysfunction, In the 43 patients with β-thalassemia major there were 18 patients with glomerular dysfunction (41.9%). There were significant differences between patients with and patients without glomerular dysfunction as regards age, urine albumin to creatinine ratio, serum Cyst-C, Serum creatinine, estimated GFRcys, hemoglobin and insignificant differences as regads sex, weight, height, BMI, splenectomy, using iron chelators or drugs for osteoporosis, blood requirement (ml/Kg/year) or ferritin level more than 1000.
Conclusion
our study revealed presence of glomerular dysfunctions in about (41.9%) of adult β-TM patients, age and pretransfusion hemoglobin level are predictors for glomerular dysfunctions. CKD-EPI-CysC equation for eGFR can detect early renal damage in these patients.
Session topic: 28. Thalassemias
Keyword(s): Anemia
Abstract: PB2489
Type: Publication Only
Background
β thalassemia major associated nephropathy has recently been a growing matter of concern affecting most aging thalassemia major patients. Serum creatinine is alone an unreliable indicator of renal functions.
Aims
The aim of the present study is to investigate the presence of glomerular dysfunctions in adults with β thalassemia major (β-TM), using early biomarkers of glomerular dysfunctions.
Methods
50 patients with β-TM were subjected to history taking and clinical examination. Urinary albumin/creatinine ratio (ACR), Serum cystatin-C (SCys-C) levels were measured and CKD-EPI-CysC equation for estimated glomerular filtration rate (eGFR) were calculated. Presence of ACR>300mg/g and/or decreased eGFR cys were considered as glomerular dysfunction.
Results
Cases with HCV infection or diabetes were excluded from our analysis for possible risk factors for glomerular dysfunction, In the 43 patients with β-thalassemia major there were 18 patients with glomerular dysfunction (41.9%). There were significant differences between patients with and patients without glomerular dysfunction as regards age, urine albumin to creatinine ratio, serum Cyst-C, Serum creatinine, estimated GFRcys, hemoglobin and insignificant differences as regads sex, weight, height, BMI, splenectomy, using iron chelators or drugs for osteoporosis, blood requirement (ml/Kg/year) or ferritin level more than 1000.
Conclusion
our study revealed presence of glomerular dysfunctions in about (41.9%) of adult β-TM patients, age and pretransfusion hemoglobin level are predictors for glomerular dysfunctions. CKD-EPI-CysC equation for eGFR can detect early renal damage in these patients.
Session topic: 28. Thalassemias
Keyword(s): Anemia